Science 28 April 1989: Vol. 244. no. 4903, pp. 463 - 465 DOI: 10.1126/science.2497519

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Articles

Expression-independent gene trap vectors for random and targeted mutagenesis in embryonic stem cells.

A. Tsakiridis, E. Tzouanacou, A. Rahman, D. Colby, R. Axton, I. Chambers, V. Wilson, L. Forrester, and J. M. Brickman (2009)
Nucleic Acids Res. 37, e129
 |  Abstract »  |  Full Text »  |  PDF »

Using retroviruses as a mutagenesis tool to explore the zebrafish genome.

L.-E. Jao, L. Maddison, W. Chen, and S. M. Burgess (2008)
Brief Funct Genomic Proteomic 7, 427-443
 |  Abstract »  |  Full Text »  |  PDF »

Deficiency in ubiquitin ligase TRIM2 causes accumulation of neurofilament light chain and neurodegeneration.

M. Balastik, F. Ferraguti, A. Pires-da Silva, T. H. Lee, G. Alvarez-Bolado, K. P. Lu, and P. Gruss (2008)
PNAS 105, 12016-12021
 |  Abstract »  |  Full Text »  |  PDF »

Gene trap mutagenesis: a functional genomics approach towards reproductive research.

T. Lee, C. Shah, and E. Y. Xu (2007)
Mol. Hum. Reprod. 13, 771-779
 |  Abstract »  |  Full Text »  |  PDF »

Exploring Strategies for Protein Trapping in Drosophila.

A. T. Quinones-Coello, L. N. Petrella, K. Ayers, A. Melillo, S. Mazzalupo, A. M. Hudson, S. Wang, C. Castiblanco, M. Buszczak, R. A. Hoskins, et al. (2007)
Genetics 175, 1089-1104
 |  Abstract »  |  Full Text »  |  PDF »

The Carnegie Protein Trap Library: A Versatile Tool for Drosophila Developmental Studies.

M. Buszczak, S. Paterno, D. Lighthouse, J. Bachman, J. Planck, S. Owen, A. D. Skora, T. G. Nystul, B. Ohlstein, A. Allen, et al. (2007)
Genetics 175, 1505-1531
 |  Abstract »  |  Full Text »  |  PDF »

A Novel Murine Gene, Sickle tail, Linked to the Danforth's short tail Locus, Is Required for Normal Development of the Intervertebral Disc.

K. Semba, K. Araki, Z. Li, K.-i. Matsumoto, M. Suzuki, N. Nakagata, K. Takagi, M. Takeya, K. Yoshinobu, M. Araki, et al. (2006)
Genetics 172, 445-456
 |  Abstract »  |  Full Text »  |  PDF »

Two ways to trap a gene in mice.

W. C. Skarnes (2005)
PNAS 102, 13001-13002
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Myocardin-related transcription factor B is required in cardiac neural crest for smooth muscle differentiation and cardiovascular development.

J. Li, X. Zhu, M. Chen, L. Cheng, D. Zhou, M. M. Lu, K. Du, J. A. Epstein, and M. S. Parmacek (2005)
PNAS 102, 8916-8921
 |  Abstract »  |  Full Text »  |  PDF »

Embryonic Stem Cells: Prospects for Developmental Biology and Cell Therapy.

A. M. Wobus and K. R. Boheler (2005)
Physiol Rev 85, 635-678
 |  Abstract »  |  Full Text »  |  PDF »

Suppression of nonsense-mediated mRNA decay permits unbiased gene trapping in mouse embryonic stem cells.

T. Shigeoka, M. Kawaichi, and Y. Ishida (2005)
Nucleic Acids Res. 33, e20
 |  Abstract »  |  Full Text »  |  PDF »

Gene trap and gene inversion methods for conditional gene inactivation in the mouse.

H.-B. Xin, K.-Y. Deng, B. Shui, S. Qu, Q. Sun, J. Lee, K. S. Greene, J. Wilson, Y. Yu, M. Feldman, et al. (2005)
Nucleic Acids Res. 33, e14
 |  Abstract »  |  Full Text »  |  PDF »

Genomics and Clinical Medicine: Rationale for Creating and Effectively Evaluating Animal Models.

K. S. Swanson, M. J. Mazur, K. Vashisht, L. A. Rund, J. E. Beever, C. M. Counter, and L. B. Schook (2004)
Experimental Biology and Medicine 229, 866-875
 |  Abstract »  |  Full Text »  |  PDF »

A piggyBac Transposon Gene Trap for the Analysis of Gene Expression and Function in Drosophila.

C. P. Bonin and R. S. Mann (2004)
Genetics 167, 1801-1811
 |  Abstract »  |  Full Text »  |  PDF »

Gene trap as a tool for genome annotation and analysis of X chromosome inactivation in human embryonic stem cells.

S. K. Dhara and N. Benvenisty (2004)
Nucleic Acids Res. 32, 3995-4002
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of Sleeping Beauty Transposition and Its Application to Genetic Screening in Mice.

K. Horie, K. Yusa, K. Yae, J. Odajima, S. E. J. Fischer, V. W. Keng, T. Hayakawa, S. Mizuno, G. Kondoh, T. Ijiri, et al. (2003)
Mol. Cell. Biol. 23, 9189-9207
 |  Abstract »  |  Full Text »  |  PDF »

Replication and episomal maintenance of Epstein-Barr virus-based vectors in mouse embryonal fibroblasts enable synthetic lethality screens.

Y. Einav, E. Shistik, M. Shenfeld, A. H. Simons, D. W. Melton, and D. Canaani (2003)
Mol. Cancer Ther. 2, 1121-1128
 |  Abstract »  |  Full Text »  |  PDF »

A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.

J. Hansen, T. Floss, P. Van Sloun, E.-M. Fuchtbauer, F. Vauti, H.-H. Arnold, F. Schnutgen, W. Wurst, H. von Melchner, and P. Ruiz (2003)
PNAS 100, 9918-9922
 |  Abstract »  |  Full Text »  |  PDF »

Tools for targeted manipulation of the mouse genome.

L. van der Weyden, D. J. Adams, and A. Bradley (2002)
Physiol Genomics 11, 133-164
 |  Abstract »  |  Full Text »  |  PDF »

Nephrin TRAP Mice Lack Slit Diaphragms and Show Fibrotic Glomeruli and Cystic Tubular Lesions.

M. Rantanen, T. Palmen, A. Patari, H. Ahola, S. Lehtonen, E. Astrom, T. Floss, F. Vauti, W. Wurst, P. Ruiz, et al. (2002)
J. Am. Soc. Nephrol. 13, 1586-1594
 |  Abstract »  |  Full Text »  |  PDF »

Design of an HIV-1 lentiviral-based gene-trap vector to detect developmentally regulated genes in mammalian cells.

Z. Lai, I. Han, M. Park, and R. O. Brady (2002)
PNAS 99, 3651-3656
 |  Abstract »  |  Full Text »  |  PDF »

Efficient chromosomal transposition of a Tc1/mariner- like transposon Sleeping Beauty in mice.

K. Horie, A. Kuroiwa, M. Ikawa, M. Okabe, G. Kondoh, Y. Matsuda, and J. Takeda (2001)
PNAS 98, 9191-9196
 |  Abstract »  |  Full Text »  |  PDF »

Human Pluripotential Stem Cells.

S. Wang and J. D. Gearhart (2000)
NeoReviews 1, e132-136
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Gene Traps: Tools for Plant Development and Genomics.

P. S. Springer (2000)
PLANT CELL 12, 1007-1020
 |  Abstract »  |  Full Text »

Capture of cytokine-responsive genes (NACA and RBM3) using a gene trap approach.

S. Baghdoyan, P. Dubreuil, F. Eberle, and S. Gomez (2000)
Blood 95, 3750-3757
 |  Abstract »  |  Full Text »  |  PDF »

E-MAP-115, encoding a microtubule-associated protein, is a retinoic acid-inducible gene required for spermatogenesis.

M. Komada, D. J. McLean, M. D. Griswold, L. D. Russell, and P. Soriano (2000)
Genes & Dev. 14, 1332-1342
 |  Abstract »  |  Full Text »

Spatial specification of mammalian eye territories by reciprocal transcriptional repression of Pax2 and Pax6.

M Schwarz, F Cecconi, G Bernier, N Andrejewski, B Kammandel, M Wagner, and P Gruss (2000)
Development 127, 4325-4334
 |  Abstract »  |  PDF »

Hunting with Traps: Genome-Wide Strategies for Gene Discovery and Functional Analysis.

K. Durick, J. Mendlein, and K. G. Xanthopoulos (1999)
Genome Res. 9, 1019-1025
 |  Abstract »  |  Full Text »

A large-scale insertional mutagenesis screen in zebrafish.

A. Amsterdam, S. Burgess, G. Golling, W. Chen, Z. Sun, K. Townsend, S. Farrington, M. Haldi, and N. Hopkins (1999)
Genes & Dev. 13, 2713-2724
 |  Abstract »  |  Full Text »

The Berkeley Drosophila Genome Project Gene Disruption Project: Single P-Element Insertions Mutating 25% of Vital Drosophila Genes.

A. C. Spradling, D. Stern, A. Beaton, E. J. Rhem, T. Laverty, N. Mozden, S. Misra, and G. M. Rubin (1999)
Genetics 153, 135-177
 |  Abstract »  |  Full Text »

Increased Anxiety and Impaired Pain Response in Puromycin-Sensitive Aminopeptidase Gene-Deficient Mice Obtained by a Mouse Gene-Trap Method.

T. Osada, S. Ikegami, K. Takiguchi-Hayashi, Y. Yamazaki, Y. Katoh-Fukui, T. Higashinakagawa, Y. Sakaki, and T. Takeuchi (1999)
J. Neurosci. 19, 6068-6078
 |  Abstract »  |  Full Text »  |  PDF »

Enhanced In Situ Detection of ß-Glucuronidase Activity in Murine Tissue.

G. C. Kopen, D. J. Prockop, and D. G. Phinney (1999)
J. Histochem. Cytochem. 47, 965-968
 |  Abstract »  |  Full Text »

Mice Homozygous for a Truncated Form of CREB-Binding Protein Exhibit Defects in Hematopoiesis and Vasculo-angiogenesis.

Y. Oike, N. Takakura, A. Hata, T. Kaname, M. Akizuki, Y. Yamaguchi, H. Yasue, K. Araki, K.-i. Yamamura, and T. Suda (1999)
Blood 93, 2771-2779
 |  Abstract »  |  Full Text »  |  PDF »

Expression Trapping: Identification of Novel Genes Expressed in Hematopoietic and Endothelial Lineages by Gene Trapping in ES Cells.

W. L. Stanford, G. Caruana, K. A. Vallis, M. Inamdar, M. Hidaka, V. L. Bautch, and A. Bernstein (1998)
Blood 92, 4622-4631
 |  Abstract »  |  Full Text »  |  PDF »

Decreased Neonatal Dietary Fat Absorption and T Cell Cytotoxicity in Pancreatic Lipase-related Protein 2-Deficient Mice.

M. E. Lowe, M. H. Kaplan, L. Jackson-Grusby, D. D'Agostino, and M. J. Grusby (1998)
J. Biol. Chem. 273, 31215-31221
 |  Abstract »  |  Full Text »  |  PDF »

A cis-acting element that directs the activity of the murine methylation modifier locus Ssm1.

P. Engler, L. T. Doglio, G. Bozek, and U. Storb (1998)
PNAS 95, 10763-10768
 |  Abstract »  |  Full Text »  |  PDF »

Gene Trapping Identifies Inhibitors of Oncogenic Transformation. THE TISSUE INHIBITOR OF METALLOPROTEINASES-3 (TIMP3) AND COLLAGEN TYPE I alpha 2 (COL1A2) ARE EPIDERMAL GROWTH FACTOR-REGULATED GROWTH REPRESSORS.

T. Andreu, T. Beckers, E. Thoenes, P. Hilgard, and H. von Melchner (1998)
J. Biol. Chem. 273, 13848-13854
 |  Abstract »  |  Full Text »  |  PDF »

Transposition of the mariner element from Drosophila mauritiana in zebrafish.

J. M. Fadool, D. L. Hartl, and J. E. Dowling (1998)
PNAS 95, 5182-5186
 |  Abstract »  |  Full Text »  |  PDF »

Isolation of Developmentally Regulated Genes from Toxoplasma gondii by a Gene Trap with the Positive and Negative Selectable Marker Hypoxanthine-Xanthine-Guanine Phosphoribosyltransferase.

L. J. Knoll and J. C. Boothroyd (1998)
Mol. Cell. Biol. 18, 807-814
 |  Abstract »  |  Full Text »

Capturing novel mouse genes encoding chromosomal and other nuclear proteins.

P Tate, M Lee, S Tweedie, W. Skarnes, and W. Bickmore (1998)
J. Cell Sci. 111, 2575-2585
 |  Abstract »  |  PDF »

An upstream, DNase I hypersensitive region of the hematopoietic-expressed transcription factor GATA-1 gene confers developmental specificity in transgenic mice.

M. A. McDevitt, Y. Fujiwara, R. A. Shivdasani, and S. H. Orkin (1997)
PNAS 94, 7976-7981
 |  Abstract »  |  Full Text »  |  PDF »

Rapid sequence analysis of gene trap integrations to generate a resource of insertional mutations in mice..

D J Townley, B J Avery, B Rosen, and W C Skarnes (1997)
Genome Res. 7, 293-298
 |  Abstract »  |  PDF »

An alpha -E-catenin gene trap mutation defines its function in preimplantation development.

M. Torres, A. Stoykova, O. Huber, K. Chowdhury, P. Bonaldo, A. Mansouri, S. Butz, R. Kemler, and P. Gruss (1997)
PNAS 94, 901-906
 |  Abstract »  |  Full Text »  |  PDF »

Patterns of gene action in plant development revealed by enhancer trap and gene trap transposable elements..

V Sundaresan, P Springer, T Volpe, S Haward, J D Jones, C Dean, H Ma, and R Martienssen (1995)
Genes & Dev. 9, 1797-1810
 |  Abstract »  |  PDF »

Gene trap capture of a novel mouse gene, jumonji, required for neural tube formation..

T Takeuchi, Y Yamazaki, Y Katoh-Fukui, R Tsuchiya, S Kondo, J Motoyama, and T Higashinakagawa (1995)
Genes & Dev. 9, 1211-1222
 |  Abstract »  |  PDF »

The T gene is necessary for normal mesodermal morphogenetic cell movements during gastrulation.

V Wilson, L Manson, W. Skarnes, and R. Beddington (1995)
Development 121, 877-886
 |  Abstract »  |  PDF »

Genetically Engineered Mice: Tools To Understand Craniofacial Development.

M. A. Ignelzi Jr, Y.-H. Liu, R. E. Maxson Jr, and M. L. Snead (1995)
Critical Reviews in Oral Biology & Medicine 6, 181-201
 |  Abstract »  |  Full Text »  |  PDF »

Transcriptional enhancer factor 1 disruption by a retroviral gene trap leads to heart defects and embryonic lethality in mice..

Z Chen, G A Friedrich, and P Soriano (1994)
Genes & Dev. 8, 2293-2301
 |  Abstract »  |  PDF »

A murine homolog of the yeast RNA1 gene is required for postimplantation development..

J DeGregori, A Russ, H von Melchner, H Rayburn, P Priyaranjan, N A Jenkins, N G Copeland, and H E Ruley (1994)
Genes & Dev. 8, 265-276
 |  Abstract »  |  PDF »

PES-1 is expressed during early embryogenesis in Caenorhabditis elegans and has homology to the fork head family of transcription factors.

I. Hope (1994)
Development 120, 505-514
 |  Abstract »  |  PDF »

Expression of a lacZ transgene reveals floor plate cell morphology and macromolecular transfer to commissural axons.

R. M. Campbell and A. C. Peterson (1993)
Development 119, 1217-1228
 |  Abstract »  |  PDF »

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes.

A. Brand and N Perrimon (1993)
Development 118, 401-415
 |  Abstract »  |  PDF »

Isolated sequences from the linked Myf-5 and MRF4 genes drive distinct patterns of muscle-specific expression in transgenic mice.

A Patapoutian, J. Miner, G. Lyons, and B Wold (1993)
Development 118, 61-69
 |  Abstract »  |  PDF »

Two enhancer regions in the mouse En-2 locus direct expression to the mid/hindbrain region and mandibular myoblasts.

C Logan, W. Khoo, D Cado, and A. Joyner (1993)
Development 117, 905-916
 |  Abstract »  |  PDF »

A gene trap approach in mouse embryonic stem cells: the lacZ reported is activated by splicing, reflects endogenous gene expression, and is mutagenic in mice..

W C Skarnes, B A Auerbach, and A L Joyner (1992)
Genes & Dev. 6, 903-918
 |  Abstract »  |  PDF »

Selective disruption of genes expressed in totipotent embryonal stem cells..

H von Melchner, J V DeGregori, H Rayburn, S Reddy, C Friedel, and H E Ruley (1992)
Genes & Dev. 6, 919-927
 |  Abstract »  |  PDF »

Expression of Pax-3- and neuroectoderm-inducing activities during differentiation of P19 embryonal carcinoma cells.

S. Pruitt (1992)
Development 116, 573-583
 |  Abstract »  |  PDF »

Of fin and fur: mutational analysis of vertebrate embryonic development..

J Rossant and N Hopkins (1992)
Genes & Dev. 6, 1-13
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Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice..

G Friedrich and P Soriano (1991)
Genes & Dev. 5, 1513-1523
 |  Abstract »  |  PDF »

Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis..

J Rossant, R Zirngibl, D Cado, M Shago, and V Giguere (1991)
Genes & Dev. 5, 1333-1344
 |  Abstract »  |  PDF »

Molecular basis of mouse developmental mutants..

A D Reith and A Bernstein (1991)
Genes & Dev. 5, 1115-1123
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Murine developmental control genes.

M Kessel and P Gruss (1990)
Science 249, 374-379
 |  Abstract »  |  PDF »

Developmental expression of the endogenous TIMP gene and a TIMP-lacZ fusion gene in transgenic mice..

A M Flenniken and B R Williams (1990)
Genes & Dev. 4, 1094-1106
 |  Abstract »  |  PDF »

Gene targeting at the human CD4 locus by epitope addition..

M Jasin, S J Elledge, R W Davis, and P Berg (1990)
Genes & Dev. 4, 157-166
 |  Abstract »  |  PDF »

P-element-mediated enhancer detection: an efficient method for isolating and characterizing developmentally regulated genes in Drosophila..

C Wilson, R K Pearson, H J Bellen, C J O'Kane, U Grossniklaus, and W J Gehring (1989)
Genes & Dev. 3, 1301-1313
 |  Abstract »  |  PDF »

Transcriptionally Defective Retroviruses Containing lacZ for the In Situ Detection of Endogenous Genes and Developmentally Regulated Chromatin.

W.G. Kerr, G.P. Nolan, A.T. Serafini, and L.A. Herzenberg (1989)
Cold Spring Harb Symp Quant Biol 54, 767-776
 |  Abstract »  |  PDF »

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