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Science 28 April 1989:
Vol. 244. no. 4903, pp. 457 - 460
DOI: 10.1126/science.2497518
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Articles

Science, Vol 244, Issue 4903, 457-460
Copyright © 1989 by American Association for the Advancement of Science

articles

Kappa B-specific DNA binding proteins: role in the regulation of human interleukin-2 gene expression

B Hoyos, DW Ballard, E Bohnlein, M Siekevitz, and WC Greene

Mount Sinai Medical Center, Department of Microbiology, New York, NY 10029.

Transcriptional activation of the human interleukin-2 (IL-2) gene, like induction of the IL-2 receptor alpha (IL-2R alpha) gene and the type 1 human immunodeficiency virus (HIV-1), is shown to be modulated by a kappa B-like enhancer element. Mutation of a kappa B core sequence identified in the IL-2 promoter (-206 to -195) partially inhibits both mitogen- and HTLV-I Tax-mediated activation of this transcription unit and blocks the specific binding of two inducible cellular factors. These kappa B-specific proteins (80 to 90 and 50 to 55 kilodaltons) similarly interact with the functional kappa B enhancer present in the IL-2R alpha promoter. These data suggest that these kappa B-specific proteins have a role in the coordinate regulation of this growth factor-growth factor receptor gene system that controls T cell proliferation.


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