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Science 14 April 1989:
Vol. 244. no. 4901, pp. 224 - 226
DOI: 10.1126/science.2704997
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Articles

Science, Vol 244, Issue 4901, 224-226
Copyright © 1989 by American Association for the Advancement of Science

articles

Inescapable versus escapable shock modulates long-term potentiation in the rat hippocampus

TJ Shors, TB Seib, S Levine, and RF Thompson

Department of Psychology, University of Southern California, Los Angeles 90089.

A group of rats was trained to escape low-intensity shock in a shuttle-box test, while another group of yoked controls could not escape but was exposed to the same amount and regime of shock. After 1 week of training, long-term potentiation (LTP) was measured in vitro in hippocampal slices. Exposure to uncontrollable shock massively impaired LTP relative to exposure to the same amount and regime of controllable shock. These results provide evidence that controllability modulates plasticity at the cellular-neuronal level.


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