Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 14 April 1989:
Vol. 244. no. 4901, pp. 217 - 221
DOI: 10.1126/science.2649981
Prev | Table of Contents | Next

Articles

Science, Vol 244, Issue 4901, 217-221
Copyright © 1989 by American Association for the Advancement of Science

articles

Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas

SJ Baker, ER Fearon, JM Nigro, Hamilton SR, AC Preisinger, JM Jessup, P vanTuinen, DH Ledbetter, DF Barker, Y Nakamura, R White, and B Vogelstein

Oncology Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231.

Previous studies have demonstrated that allelic deletions of the short arm of chromosome 17 occur in over 75% of colorectal carcinomas. Twenty chromosome 17p markers were used to localize the common region of deletion in these tumors to a region contained within bands 17p12 to 17p13.3. This region contains the gene for the transformation-associated protein p53. Southern and Northern blot hybridization experiments provided no evidence for gross alterations of the p53 gene or surrounding sequences. As a more rigorous test of the possibility that p53 was a target of the deletions, the p53 coding regions from two tumors were analyzed; these two tumors, like most colorectal carcinomas, had allelic deletions of chromosome 17p and expressed considerable amounts of p53 messenger RNA from the remaining allele. The remaining p53 allele was mutated in both tumors, with an alanine substituted for valine at codon 143 of one tumor and a histidine substituted for arginine at codon 175 of the second tumor. Both mutations occurred in a highly conserved region of the p53 gene that was previously found to be mutated in murine p53 oncogenes. The data suggest that p53 gene mutations may be involved in colorectal neoplasia, perhaps through inactivation of a tumor suppressor function of the wild-type p53 gene.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
REVIEW PAPER: Implications of the "Cancer Stem Cell" Hypothesis on Murine Models of Colon Cancer and Colitis-associated Cancer.
M. J. Hynes, K. M. Huang, and E. H. Huang (2009)
Vet. Pathol. 46, 819-835
   Abstract »    Full Text »    PDF »
Did Experimental Biology Die? Lessons from 30 Years of p53 Research.
S. Madar, I. Goldstein, and V. Rotter (2009)
Cancer Res. 69, 6378-6380
   Full Text »    PDF »
Sample Type Bias in the Analysis of Cancer Genomes.
D. A. Solomon, J.-S. Kim, H. W. Ressom, Z. Sibenaller, T. Ryken, W. Jean, D. Bigner, H. Yan, and T. Waldman (2009)
Cancer Res. 69, 5630-5633
   Abstract »    Full Text »    PDF »
Field Effect in Cancer-An Update.
H. Chai and R. E. Brown (2009)
Ann. Clin. Lab. Sci. 39, 331-337
   Abstract »    Full Text »    PDF »
AIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53.
J. M. Han, B.-J. Park, S. G. Park, Y. S. Oh, S. J. Choi, S. W. Lee, S.-K. Hwang, S.-H. Chang, M.-H. Cho, and S. Kim (2008)
PNAS 105, 11206-11211
   Abstract »    Full Text »    PDF »
Regulatory Functions of the N-terminal Domain of the 70-kDa Subunit of Replication Protein A (RPA).
S. K. Binz and M. S. Wold (2008)
J. Biol. Chem. 283, 21559-21570
   Abstract »    Full Text »    PDF »
Comparative lesion sequencing provides insights into tumor evolution.
S. Jones, W.-d. Chen, G. Parmigiani, F. Diehl, N. Beerenwinkel, T. Antal, A. Traulsen, M. A. Nowak, C. Siegel, V. E. Velculescu, et al. (2008)
PNAS 105, 4283-4288
   Abstract »    Full Text »    PDF »
Association of the TP53 Codon 72 Polymorphism with Colorectal Cancer in a Chinese Population.
Z.-Z. Zhu, A.-Z. Wang, H.-R. Jia, X.-X. Jin, X.-L. He, L.-F. Hou, and G. Zhu (2007)
Jpn. J. Clin. Oncol. 37, 385-390
   Abstract »    Full Text »    PDF »
The Significance of c-erbB-2 Overexpression and p53 Expression in Patients With Axillary Lymph Node--Negative Breast Cancer: A Tissue Microarray Study.
S.-S. Ko, Y.-S. Na, C.-S. Yoon, J.-Y. Park, H.-S. Kim, M.-H. Hur, H.-K. Lee, Y.-K. Chun, S.-S. Kang, B.-W. Park, et al. (2007)
International Journal of Surgical Pathology 15, 98-109
   Abstract »    PDF »
Distinguishing Cancer-Associated Missense Mutations from Common Polymorphisms.
J. S. Kaminker, Y. Zhang, A. Waugh, P. M. Haverty, B. Peters, D. Sebisanovic, J. Stinson, W. F. Forrest, J. F. Bazan, S. Seshagiri, et al. (2007)
Cancer Res. 67, 465-473
   Abstract »    Full Text »    PDF »
Phase I, Pharmacokinetic, and Pharmacodynamic Study of Intravenously Administered Ad5CMV-p53, an Adenoviral Vector Containing the Wild-Type p53 Gene, in Patients With Advanced Cancer.
A. W. Tolcher, D. Hao, J. de Bono, A. Miller, A. Patnaik, L. A. Hammond, L. Smetzer, J. Van Wart Hood, J. Merritt, E. K. Rowinsky, et al. (2006)
J. Clin. Oncol. 24, 2052-2058
   Abstract »    Full Text »    PDF »
Genetic Mechanisms of TP53 Loss of Heterozygosity in Barrett's Esophagus: Implications for Biomarker Validation..
V. J. Wongsurawat, J. C. Finley, P. C. Galipeau, C. A. Sanchez, C. C. Maley, X. Li, P. L. Blount, R. D. Odze, P. S. Rabinovitch, and B. J. Reid (2006)
Cancer Epidemiol. Biomarkers Prev. 15, 509-516
   Abstract »    Full Text »    PDF »
The TP53 Colorectal Cancer International Collaborative Study on the Prognostic and Predictive Significance of p53 Mutation: Influence of Tumor Site, Type of Mutation, and Adjuvant Treatment.
A. Russo, V. Bazan, B. Iacopetta, D. Kerr, T. Soussi, N. Gebbia, and for the TP53-CRC Collaborative Study Group (2005)
J. Clin. Oncol. 23, 7518-7528
   Abstract »    Full Text »    PDF »
Role of Stat3 in Regulating p53 Expression and Function.
G. Niu, K. L. Wright, Y. Ma, G. M. Wright, M. Huang, R. Irby, J. Briggs, J. Karras, W. D. Cress, D. Pardoll, et al. (2005)
Mol. Cell. Biol. 25, 7432-7440
   Abstract »    Full Text »    PDF »
A Chromatin-associated and Transcriptionally Inactive p53-Mdm2 Complex Occurs in mdm2 SNP309 Homozygous Cells.
N. C. Arva, T. R. Gopen, K. E. Talbott, L. E. Campbell, A. Chicas, D. E. White, G. L. Bond, A. J. Levine, and J. Bargonetti (2005)
J. Biol. Chem. 280, 26776-26787
   Abstract »    Full Text »    PDF »
Evolution of intratumoral genetic heterogeneity during colorectal cancer progression.
L. Losi, B. Baisse, H. Bouzourene, and J. Benhattar (2005)
Carcinogenesis 26, 916-922
   Abstract »    Full Text »    PDF »
Elimination of Hepatic Metastases of Colon Cancer Cells via p53-Independent Cross-Talk between Irinotecan and Apo2 Ligand/TRAIL.
R. Ravi, A. J. Jain, R. D. Schulick, V. Pham, T. S. Prouser, H. Allen, E. G. Mayer, H. Yu, D. M. Pardoll, A. Ashkenazi, et al. (2004)
Cancer Res. 64, 9105-9114
   Abstract »    Full Text »    PDF »
Use of microsatellite marker loss of heterozygosity in accurate diagnosis of pancreaticobiliary malignancy from brush cytology samples.
A Khalid, R Pal, E Sasatomi, P Swalsky, A Slivka, D Whitcomb, and S Finkelstein (2004)
Gut 53, 1860-1865
   Abstract »    Full Text »    PDF »
Molecular Differences between Sporadic Serrated and Conventional Colorectal Adenomas.
K. Konishi, T. Yamochi, R. Makino, K. Kaneko, T. Yamamoto, H. Nozawa, A. Katagiri, H. Ito, K. Nakayama, H. Ota, et al. (2004)
Clin. Cancer Res. 10, 3082-3090
   Abstract »    Full Text »    PDF »
Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients.
T.-L. Wang, L. A. Diaz Jr., K. Romans, A. Bardelli, S. Saha, G. Galizia, M. Choti, R. Donehower, G. Parmigiani, I.-M. Shih, et al. (2004)
PNAS 101, 3089-3094
   Abstract »    Full Text »    PDF »
Prognostic significance of the allelic loss of the BRCA1 gene in colorectal cancer.
J M Garcia, R Rodriguez, G Dominguez, J M Silva, M Provencio, J Silva, A Colmenarejo, I Millan, C Munoz, C Salas, et al. (2003)
Gut 52, 1756-1763
   Abstract »    Full Text »    PDF »
The PDZ Protein Tax-interacting Protein-1 Inhibits {beta}-Catenin Transcriptional Activity and Growth of Colorectal Cancer Cells.
M. Kanamori, P. Sandy, S. Marzinotto, R. Benetti, C. Kai, Y. Hayashizaki, C. Schneider, and H. Suzuki (2003)
J. Biol. Chem. 278, 38758-38764
   Abstract »    Full Text »    PDF »
Identification of S100A2 as a Target of the {Delta}Np63 Oncogenic Pathway.
K. Hibi, S.-i. Fujitake, T. Takase, Y. Kodera, K. Ito, S. Akiyama, M. Shirane, and A. Nakao (2003)
Clin. Cancer Res. 9, 4282-4285
   Abstract »    Full Text »    PDF »
Alterations of the Birt-Hogg-Dube gene (BHD) in sporadic colorectal tumours.
K Kahnoski, S K Khoo, N T Nassif, J Chen, G P Lobo, E Segelov, and B T Teh (2003)
J. Med. Genet. 40, 511-515
   Full Text »    PDF »
Mutation and LOH analysis of ACO2 in colorectal cancer: no evidence of biallelic genetic inactivation.
P Laiho, T Hienonen, J-P Mecklin, H Jarvinen, A Karhu, V Launonen, and L A Aaltonen (2003)
J. Med. Genet. 40, e73-73
   Full Text »    PDF »
A Cancer-prone Case with a Background of Methylation of p16 Tumor Suppressor Gene.
K. Hibi, M. Koike, H. Nakayama, S. Fujitake, Y. Kasai, K. Ito, S. Akiyama, and A. Nakao (2003)
Clin. Cancer Res. 9, 1053-1056
   Abstract »    Full Text »    PDF »
A novel case with germline p53 gene mutation having concurrent multiple primary colon tumours.
M Miyaki, T Iijima, M Ohue, Y Kita, T Hishima, T Kuroki, T Iwama, and T Mori (2003)
Gut 52, 304-306
   Abstract »    Full Text »    PDF »
Low-penetrance Genes and Their Involvement in Colorectal Cancer Susceptibility.
M. M. de Jong, I. M. Nolte, G. J. te Meerman, W. T. A. van der Graaf, E. G. E. de Vries, R. H. Sijmons, R. M. W. Hofstra, and J. H. Kleibeuker (2002)
Cancer Epidemiol. Biomarkers Prev. 11, 1332-1352
   Abstract »    Full Text »    PDF »
Gene Expression in Colorectal Cancer.
K. Birkenkamp-Demtroder, L. L. Christensen, S. H. Olesen, C. M. Frederiksen, P. Laiho, L. A. Aaltonen, S. Laurberg, F. B. Sorensen, R. Hagemann, and T. F. Orntoft (2002)
Cancer Res. 62, 4352-4363
   Abstract »    Full Text »    PDF »
Induction of Gene Amplification as a Gain-of-Function Phenotype of Mutant p53 Proteins.
S. El-Hizawi, J. P. Lagowski, M. Kulesz-Martin, and A. Albor (2002)
Cancer Res. 62, 3264-3270
   Abstract »    Full Text »    PDF »
Age-associated loss of heterozygosity of tumor suppressor genes in the gastric mucosa of humans.
L. Moragoda, R. Jaszewski, P. Kulkarni, and A. P. N. Majumdar (2002)
Am J Physiol Gastrointest Liver Physiol 282, G932-G936
   Abstract »    Full Text »    PDF »
Down-Regulation of {beta}-Catenin by Activated p53.
E. Sadot, B. Geiger, M. Oren, and A. Ben-Ze'ev (2001)
Mol. Cell. Biol. 21, 6768-6781
   Abstract »    Full Text »    PDF »
Nuclear Localization of {beta}-Catenin and Plakoglobin in Primary and Metastatic Human Colonic Carcinomas, Colonic Adenomas, and Normal Colon.
B. Lifschitz-Mercer, R. Amitai, B. B.-S. Maymon, L. Shechtman, B. Czernobilsky, L. Leider-Trejo, A. Ben-Ze'ev, and B. Geiger (2001)
International Journal of Surgical Pathology 9, 273-279
   Abstract »    PDF »
Alterations of Gene Expression during Colorectal Carcinogenesis Revealed by cDNA Microarrays after Laser-Capture Microdissection of Tumor Tissues and Normal Epithelia.
O. Kitahara, Y. Furukawa, T. Tanaka, C. Kihara, K. Ono, R. Yanagawa, M. E. Nita, T. Takagi, Y. Nakamura, and T. Tsunoda (2001)
Cancer Res. 61, 3544-3549
   Abstract »    Full Text »
AIS Overexpression in Advanced Esophageal Cancer.
K. Hibi, H. Nakayama, M. Taguchi, Y. Kasai, K. Ito, S. Akiyama, and A. Nakao (2001)
Clin. Cancer Res. 7, 469-472
   Abstract »    Full Text »
Cloning and Characterization of a Novel Gene, DRH1, Down-Regulated in Advanced Human Hepatocellular Carcinoma.
Y. Yamamoto, M. Sakamoto, G. Fujii, K. Kanetaka, M. Asaka, and S. Hirohashi (2001)
Clin. Cancer Res. 7, 297-303
   Abstract »    Full Text »
Loss of Dpc4 Expression in Colonic Adenocarcinomas Correlates with the Presence of Metastatic Disease.
A. Maitra, K. Molberg, J. Albores-Saavedra, and G. Lindberg (2000)
Am. J. Pathol. 157, 1105-1111
   Abstract »    Full Text »    PDF »
Definition and Refinement of Chromosome 8p Regions of Loss of Heterozygosity in Gastric Cancer.
R. Baffa, R. Santoro, F. Bullrich, B. Mandes, H. Ishii, and C. M. Croce (2000)
Clin. Cancer Res. 6, 1372-1377
   Abstract »    Full Text »
Measurement of locus copy number by hybridisation with amplifiable probes.
J. A. L. Armour, C. Sismani, P. C. Patsalis, and G. Cross (2000)
Nucleic Acids Res. 28, 605-609
   Abstract »    Full Text »    PDF »
Mutations in the Retinoblastoma-related Gene RB2/p130 in Primary Nasopharyngeal Carcinoma.
P. P. Claudio, C. M. Howard, Y. Fu, C. Cinti, L. Califano, P. Micheli, E. W. Mercer, M. Caputi, and A. Giordano (2000)
Cancer Res. 60, 8-12
   Abstract »    Full Text »
Clinicopathological differences between colonic and rectal carcinomas: are they based on the same mechanism of carcinogenesis?.
K Konishi, T Fujii, N Boku, S Kato, I Koba, A Ohtsu, H Tajiri, A Ochiai, and S Yoshida (1999)
Gut 45, 818-821
   Abstract »    Full Text »    PDF »
Chronic Alcohol Consumption Induces Genomic but Not p53-Specific DNA Hypomethylation in Rat Colon.
S.-W. Choi, F. Stickel, H. W. Baik, Y.-I. Kim, H. K. Seitz, and J. B. Mason (1999)
J. Nutr. 129, 1945-1950
   Abstract »    Full Text »
Expression of OVCA1, a Candidate Tumor Suppressor, Is Reduced in Tumors and Inhibits Growth of Ovarian Cancer Cells.
W. Bruening, A. H. Prowse, D. C. Schultz, M. Holgado-Madruga, A. Wong, and A. K. Godwin (1999)
Cancer Res. 59, 4973-4983
   Abstract »    Full Text »    PDF »
Colorectal Cancer: Molecules and Populations.
J. D. Potter (1999)
J Natl Cancer Inst 91, 916-932
   Abstract »    Full Text »    PDF »
Loss of Heterozygosity Analysis Using Whole Genome Amplification, Cell Sorting, and Fluorescence-Based PCR.
T. G. Paulson, P. C. Galipeau, and B. J. Reid (1999)
Genome Res. 9, 482-491
   Abstract »    Full Text »
Regulation of the p53 Protein by the MDM2 Oncoprotein--Thirty-eighth G. H. A. Clowes Memorial Award Lecture.
D. A. Freedman (1999)
Cancer Res. 59, 1-7
   Full Text »    PDF »
Molecular karyotype (amplotype) of metastatic colorectal cancer by unbiased arbitrarily primed PCR DNA fingerprinting.
S. Malkhosyan, J. Yasuda, J. L. Soto, T. Sekiya, J. Yokota, and M. Perucho (1998)
PNAS 95, 10170-10175
   Abstract »    Full Text »    PDF »
Alternative genetic pathways in colorectal carcinogenesis.
S. Olschwang, R. Hamelin, P. Laurent-Puig, B. Thuille, Y. De Rycke, Y.-J. Li, F. Muzeau, J. Girodet, R.-J. Salmon, and G. Thomas (1997)
PNAS 94, 12122-12127
   Abstract »    Full Text »    PDF »
Effects of p53 mutations on apoptosis in mouse intestinal and human colonic adenomas.
A. Fazeli, R. G. Steen, S. L. Dickinson, D. Bautista, W. F. Dietrich, R. T. Bronson, R. S. Bresalier, E. S. Lander, J. Costa, and R. A. Weinberg (1997)
PNAS 94, 10199-10204
   Abstract »    Full Text »    PDF »
p53-independent apoptosis induced by paclitaxel through an indirect mechanism.
J. S. Lanni, S. W. Lowe, E. J. Licitra, J. O. Liu, and T. Jacks (1997)
PNAS 94, 9679-9683
   Abstract »    Full Text »    PDF »
Mutations of the p53 Gene as a Prognostic Factor in Aggressive B-Cell Lymphoma.
A. Ichikawa, T. Kinoshita, T. Watanabe, H. Kato, H. Nagai, K. Tsushita, H. Saito, and T. Hotta (1997)
N. Engl. J. Med. 337, 529-534
   Abstract »    Full Text »    PDF »
p53 and Breast Cancer.
P. Robbins (1996)
International Journal of Surgical Pathology 4, 93-110
   Abstract »    PDF »
Accelerated neuronal differentiation induced by p53 suppression.
A Ferreira and K. Kosik (1996)
J. Cell Sci. 109, 1509-1516
   Abstract »    PDF »
p53 Mutations and Tumor Progression in Well-differentiated Liposarcoma and Dermatofibrosarcoma Protuberans.
J. R. Goldblum, T. S. Frank, E. L. Poy, and S. W. Weiss (1995)
International Journal of Surgical Pathology 3, 35-41
   Abstract »    PDF »
Chromosome 17p Allelic Loss in Colorectal Carcinoma: Clinical Significance.
D. M. Takanishi Jr, I. Angriman, M. L. Yaremko, A. Montag, C. A. Westbrook, and F. Michelassi (1995)
Arch Surg 130, 585-589
   Abstract »    PDF »
A p53-dependent mouse spindle checkpoint.
S. Cross, C. Sanchez, C. Morgan, M. Schimke, S Ramel, R. Idzerda, W. Raskind, and B. Reid (1995)
Science 267, 1353-1356
   Abstract »    PDF »
Allelic Loss of Chromosome 18q and Prognosis in Colorectal Cancer.
J. Jen, H. Kim, S. Piantadosi, Z.-F. Liu, R. C. Levitt, P. Sistonen, K. W. Kinzler, B. Vogelstein, and S. R. Hamilton (1994)
N. Engl. J. Med. 331, 213-221
   Abstract »    Full Text »
Rates of p16 (MTS1) mutations in primary tumors with 9p loss.
P Cairns, L Mao, A Merlo, D. Lee, D Schwab, Y Eby, K Tokino, P van der Riet, J. Blaugrund, and D Sidransky (1994)
Science 265, 415-417
   PDF »
Tumorigenic and Developmental Effects of Combined Germ-line Mutations in Rb and p53.
B.O. Williams, S.D. Morgenbesser, R.A. DePinho, and T. Jacks (1994)
Cold Spring Harb Symp Quant Biol 59, 449-457
   Abstract »    PDF »
Retrieval of p53 Protein in Paraffin-Embedded Head and Neck Tumor Tissues.
Z. P. Pavelic, L. G. Portugal, M. J. Gootee, P. J. Stambrook, C. Smith, R. E. Mugge, L. Pavelic, K. Wilson, C. R. Buncher, Y.-Q. Li, et al. (1993)
Arch Otolaryngol Head Neck Surg 119, 1206-1209
   Abstract »    PDF »
Cloning of Tumor Suppressor Genes Involved in Solid Tumor Development.
D. I. Smith and M. del Mar Alonso (1993)
Arch Otolaryngol Head Neck Surg 119, 1210-1216
   Abstract »    PDF »
Human Cytogenetics: A Current Overview.
M. M. Cohen, L. S. Rosenblum-Vos, and G. Prabhakar (1993)
Arch Pediatr Adolesc Med 147, 1159-1166
   Abstract »    PDF »
Clinical Implications of the p53 Tumor-Suppressor Gene.
C. C. Harris and M. Hollstein (1993)
N. Engl. J. Med. 329, 1318-1327
   Full Text »
Clues to the pathogenesis of familial colorectal cancer.
L. Aaltonen, P Peltomaki, F. Leach, P Sistonen, L Pylkkanen, J. Mecklin, H Jarvinen, S. Powell, J Jen, Hamilton SR, et al. (1993)
Science 260, 812-816
   Abstract »    PDF »
Microsatellite instability in cancer of the proximal colon.
S. Thibodeau, G Bren, and D Schaid (1993)
Science 260, 816-819
   Abstract »    PDF »
Determination of Tumor Aggressiveness in Colorectal Cancer by K-ras-2 Analysis.
S. D. Finkelstein, R. Sayegh, A. Bakker, and P. Swalsky (1993)
Arch Surg 128, 526-532
   Abstract »    PDF »
Altered growth of human colon cancer cell lines disrupted at activated Ki-ras.
S Shirasawa, M Furuse, N Yokoyama, and T Sasazuki (1993)
Science 260, 85-88
   Abstract »    PDF »
Reconciling the Epidemiology, Physiology, and Molecular Biology of Colon Cancer.
J. D. Potter (1992)
JAMA 268, 1573-1577
   Abstract »    PDF »
Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element..
G P Zambetti, J Bargonetti, K Walker, C Prives, and A J Levine (1992)
Genes & Dev. 6, 1143-1152
   Abstract »    PDF »
Oncogenic forms of p53 inhibit p53-regulated gene expression.
S. Kern, J. Pietenpol, S Thiagalingam, A Seymour, K. Kinzler, and B Vogelstein (1992)
Science 256, 827-830
   Abstract »    PDF »
DCC: A Tumor Suppressor Gene Expressed on the Cell Surface.
L. Hedrick, K.R. Cho, J. Boyd, J. Risinger, and B. Vogelstein (1992)
Cold Spring Harb Symp Quant Biol 57, 345-351
   Abstract »    PDF »
p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts..
D M Harvey and A J Levine (1991)
Genes & Dev. 5, 2375-2385
   Abstract »    PDF »
Tumor suppressor genes.
R. Weinberg (1991)
Science 254, 1138-1146
   Abstract »    PDF »
Chromosome aberrations and cancer.
E Solomon, J Borrow, and A. Goddard (1991)
Science 254, 1153-1160
   Abstract »    PDF »
Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients.
I Nishisho, Y Nakamura, Y Miyoshi, Y Miki, H Ando, A Horii, K Koyama, J Utsunomiya, S Baba, and P Hedge (1991)
Science 253, 665-669
   Abstract »    PDF »
p53 mutations in human cancers.
M Hollstein, D Sidransky, B Vogelstein, and C. Harris (1991)
Science 253, 49-53
   Abstract »    PDF »
Identification of p53 as a sequence-specific DNA-binding protein.
S. Kern, K. Kinzler, A Bruskin, D Jarosz, P Friedman, C Prives, and B Vogelstein (1991)
Science 252, 1708-1711
   Abstract »    PDF »
Identification of p53 gene mutations in bladder cancers and urine samples.
D Sidransky, A Von Eschenbach, Y. Tsai, P Jones, I Summerhayes, F Marshall, M Paul, P Green, Hamilton SR, P Frost, et al. (1991)
Science 252, 706-709
   Abstract »    PDF »
Ubiquitin Hybrid Protein Gene Expression During Human Colon Cancer Progression.
K.-i. Mafune, J. M. Wong, R. J. Staniunas, M. L. Lu, T. S. Ravikumar, L. B. Chen, and G. D. Steele Jr (1991)
Arch Surg 126, 462-466
   Abstract »    PDF »
Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers.
K. Kinzler, M. Nilbert, B Vogelstein, T. Bryan, D. Levy, K. Smith, A. Preisinger, Hamilton SR, P Hedge, A Markham, et al. (1991)
Science 251, 1366-1370
   Abstract »    PDF »
Senescence of nickel-transformed cells by an X chromosome: possible epigenetic control.
C. Klein, K Conway, X. Wang, R. Bhamra, X. Lin, M. Cohen, L Annab, J. Barrett, and M Costa (1991)
Science 251, 796-799
   Abstract »    PDF »
Regulation of Transformation and the Cell Cycle by p53.
G.P. Zambetti, R.S. Quartin, J. Martinez, I. Georgoff, J. Momand, D. Dittmer, C.A. Finlay, and A.J. Levine (1991)
Cold Spring Harb Symp Quant Biol 56, 219-225
   Abstract »    PDF »
Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms.
D Malkin, F. Li, L. Strong, J. Fraumeni Jr, C. Nelson, D. Kim, J Kassel, M. Gryka, F. Bischoff, M. Tainsky, et al. (1990)
Science 250, 1233-1238
   Abstract »    PDF »
Different tumor-derived p53 mutants exhibit distinct biological activities.
O Halevy, D Michalovitz, and M Oren (1990)
Science 250, 113-116
   Abstract »    PDF »
What Getting Sick Means.
N. N. Abumrad and M. Frexes-Steed (1990)
JPEN J Parenter Enteral Nutr 14, 157S-163S
   Abstract »    PDF »
Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene.
L Raycroft, H. Wu, and G Lozano (1990)
Science 249, 1049-1051
   Abstract »    PDF »
Suppression of human colorectal carcinoma cell growth by wild-type p53.
S. Baker, S Markowitz, E. Fearon, J. Willson, and B Vogelstein (1990)
Science 249, 912-915
   Abstract »    PDF »
Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients.
M. Wallace, D. Marchuk, L. Andersen, R Letcher, H. Odeh, A. Saulino, J. Fountain, A Brereton, J Nicholson, A. Mitchell, et al. (1990)
Science 249, 181-186
   Abstract »    PDF »
Association of human papillomavirus types 16 and 18 E6 proteins with p53.
B. Werness, A. Levine, and P. Howley (1990)
Science 248, 76-79
   Abstract »    PDF »
SV40 stimulates expression of the transacting factor Sp1 at the mRNA level..
J D Saffer, S P Jackson, and S J Thurston (1990)
Genes & Dev. 4, 659-666
   Abstract »    PDF »
Cancer Invasion and Metastases.
L. A. Liotta and E. Kohn (1990)
JAMA 263, 1123-1126
   Abstract »    PDF »
Tumorigenicity in human melanoma cell lines controlled by introduction of human chromosome 6.
J. Trent, E. Stanbridge, H. McBride, E. Meese, G Casey, D. Araujo, C. Witkowski, and R. Nagle (1990)
Science 247, 568-571
   Abstract »    PDF »
Identifying tumor suppressor genes in human colorectal cancer.
E. Stanbridge (1990)
Science 247, 12-13
   PDF »
Identification of a chromosome 18q gene that is altered in colorectal cancers.
E. Fearon, K. Cho, J. Nigro, S. Kern, J. Simons, J. Ruppert, Hamilton SR, A. Preisinger, G Thomas, K. Kinzler, et al. (1990)
Science 247, 49-56
   Abstract »    PDF »
p53: oncogene or anti-oncogene?.
D P Lane and S Benchimol (1990)
Genes & Dev. 4, 1-8
   PDF »
Tumor suppressor genes: the puzzle and the promise.
R Sager (1989)
Science 246, 1406-1412
   Abstract »    PDF »
G1 events and regulation of cell proliferation.
A. Pardee (1989)
Science 246, 603-608
   Abstract »    PDF »
p53: a frequent target for genetic abnormalities in lung cancer.
T Takahashi, M. Nau, I Chiba, M. Birrer, R. Rosenberg, M Vinocour, M Levitt, H Pass, A. Gazdar, and J. Minna (1989)
Science 246, 491-494
   Abstract »    PDF »
Variation in HLA Expression on Tumors: An Escape from Immune Response.
M.E.F. Smith, J.G. Bodmer, A.P. Kelly, J. Trowsdale, S.C. Kirkland, and W.F. Bodmer (1989)
Cold Spring Harb Symp Quant Biol 54, 581-586
   Abstract »    PDF »
Maf Transcriptionally Activates the Mouse p53 Promoter and Causes a p53-dependent Cell Death.
T. K. Hale, C. Myers, R. Maitra, T. Kolzau, M. Nishizawa, and A. W. Braithwaite (2000)
J. Biol. Chem. 275, 17991-17999
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)