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Science 14 April 1989:
Vol. 244. no. 4901, pp. 214 - 217
DOI: 10.1126/science.2784868
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Articles

Science, Vol 244, Issue 4901, 214-217
Copyright © 1989 by American Association for the Advancement of Science

articles

Influence of the major histocompatibility complex on positive thymic selection of V beta 17a+ T cells

MA Blackman, P Marrack, and J Kappler

Howard Hughes Medical Institute, Denver, CO.

A monoclonal antibody was used to show directly positive thymic selection of the T cell repertoire in mouse strains expressing the 17a beta-chain variable domain (V beta 17a) of the T cell receptor. In the absence of the potent tolerizing class II major histocompatibility complex (MHC) molecule, I-E, peripheral expression of V beta 17a+ T cell receptors varied with the MHC haplotype of the mouse strain. In the most extreme case, H-2q mice expressed high peripheral levels of CD4+ V beta 17a+ T cells (14 to 19 percent), whereas H-2b mice expressed low levels (3 to 4 percent). Analysis of (b x q)F1 mice and chimeric mice showed that these differences were determined by positive thymic selection and implicated the thymic epithelium as the controlling cell type.


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