Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 7 April 1989:
Vol. 244. no. 4900, pp. 76 - 79
DOI: 10.1126/science.2539642
Prev | Table of Contents | Next

Articles

Science, Vol 244, Issue 4900, 76-79
Copyright © 1989 by American Association for the Advancement of Science

articles

Identification of a thyroid hormone receptor that is pituitary-specific

RA Hodin, MA Lazar, BI Wintman, DS Darling, RJ Koenig, PR Larsen, DD Moore, and WW Chin

Department of Medicine, Brigham and Women's Hospital, Boston, MA.

Three cellular homologs of the v-erbA oncogene were previously identified in the rat; two of them encode high affinity receptors for the thyroid hormone triiodothyronine (T3). A rat complementary DNA clone encoding a T3 receptor form of the ErbA protein, called r-ErbA beta-2, was isolated. The r-ErbA beta-2 protein differs at its amino terminus from the previously described rat protein encoded by c-erbA beta and referred to as r-ErbA beta-1. Unlike the other members of the c-erbA proto-oncogene family, which have a wide tissue distribution, r-erbA beta-2 appears to be expressed only in the anterior pituitary gland. In addition, thyroid hormone downregulates r-erbA beta-2 messenger RNA but not r-erbA beta-1 messenger RNA in a pituitary tumor-derived cell line. The presence of a pituitary-specific form of the thyroid hormone receptor that may be selectively regulated by thyroid hormone could be important for the differential regulation of gene expression by T3 in the pituitary gland.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Thyrotropin-Releasing Hormone and the Thyroid Hormone Feedback Mechanism.
M. I. Chiamolera and F. E. Wondisford (2009)
Endocrinology 150, 1091-1096
   Abstract »    Full Text »    PDF »
Regulation of Mammary Gland Sensitivity to Thyroid Hormones During the Transition from Pregnancy to Lactation.
A. V. Capuco, E. E. Connor, and D. L. Wood (2008)
Experimental Biology and Medicine 233, 1309-1314
   Abstract »    Full Text »    PDF »
Functional Significance of a Truncated Thyroid Receptor Subtype Lacking a Hormone-Binding Domain in Goldfish.
E. R. Nelson and H. R. Habibi (2008)
Endocrinology 149, 4702-4709
   Abstract »    Full Text »    PDF »
Thyroid hormone receptor {beta}2 is strongly up-regulated at all levels of the hypothalamo-pituitary-thyroidal axis during late embryogenesis in chicken.
S. V H Grommen, L. Arckens, T. Theuwissen, V. M Darras, and B. De Groef (2008)
J. Endocrinol. 196, 519-528
   Abstract »    Full Text »    PDF »
Expression of thyroid hormone receptors A and B in developing rat tissues; evidence for extensive posttranscriptional regulation.
R. Keijzer, P.-J. E Blommaart, W. T Labruyere, J. L M Vermeulen, B. Z. Doulabi, O. Bakker, D. Tibboel, and W. H Lamers (2007)
J. Mol. Endocrinol. 38, 523-535
   Abstract »    Full Text »    PDF »
An Intron Control Region Differentially Regulates Expression of Thyroid Hormone Receptor {beta}2 in the Cochlea, Pituitary, and Cone Photoreceptors.
I. Jones, L. Ng, H. Liu, and D. Forrest (2007)
Mol. Endocrinol. 21, 1108-1119
   Abstract »    Full Text »    PDF »
Characterization of a Novel Thyroid Hormone Receptor {alpha} Variant Involved in the Regulation of Myoblast Differentiation.
F. Casas, M. Busson, S. Grandemange, P. Seyer, A. Carazo, L. Pessemesse, C. Wrutniak-Cabello, and G. Cabello (2006)
Mol. Endocrinol. 20, 749-763
   Abstract »    Full Text »    PDF »
Dominant Role of Thyrotropin-releasing Hormone in the Hypothalamic-Pituitary-Thyroid Axis.
A. A. Nikrodhanond, T. M. Ortiga-Carvalho, N. Shibusawa, K. Hashimoto, X. H. Liao, S. Refetoff, M. Yamada, M. Mori, and F. E. Wondisford (2006)
J. Biol. Chem. 281, 5000-5007
   Abstract »    Full Text »    PDF »
Different Configurations of Specific Thyroid Hormone Response Elements Mediate Opposite Effects of Thyroid Hormone and GC-1 on Gene Expression.
B. Gloss, G. Giannocco, E. A. Swanson, A. S. Moriscot, G. Chiellini, T. Scanlan, J. D. Baxter, and W. H. Dillmann (2005)
Endocrinology 146, 4926-4933
   Abstract »    Full Text »    PDF »
Regulation of regional expression in rat brain PC2 by thyroid hormone/characterization of novel negative thyroid hormone response elements in the PC2 promoter.
X. Shen, Q.-L. Li, G. A. Brent, and T. C. Friedman (2005)
Am J Physiol Endocrinol Metab 288, E236-E245
   Abstract »    Full Text »    PDF »
Both Thyroid Hormone Receptor (TR){beta}1 and TR{beta}2 Isoforms Contribute to the Regulation of Hypothalamic Thyrotropin-Releasing Hormone.
S. M. Dupre, H. Guissouma, F. Flamant, I. Seugnet, T. S. Scanlan, J. D. Baxter, J. Samarut, B. A. Demeneix, and N. Becker (2004)
Endocrinology 145, 2337-2345
   Abstract »    Full Text »    PDF »
Exercise training improves cardiac function-related gene levels through thyroid hormone receptor signaling in aged rats.
M. Iemitsu, T. Miyauchi, S. Maeda, T. Tanabe, M. Takanashi, M. Matsuda, and I. Yamaguchi (2004)
Am J Physiol Heart Circ Physiol 286, H1696-H1705
   Abstract »    Full Text »    PDF »
Dominant Inhibition of Thyroid Hormone Action Selectively in the Pituitary of Thyroid Hormone Receptor-{beta} Null Mice Abolishes the Regulation of Thyrotropin by Thyroid Hormone.
E. D. Abel, E. G. Moura, R. S. Ahima, A. Campos-Barros, C. C. Pazos-Moura, M.-E. Boers, H. C. Kaulbach, D. Forrest, and F. E. Wondisford (2003)
Mol. Endocrinol. 17, 1767-1776
   Abstract »    Full Text »    PDF »
EcR isoforms in Drosophila: testing tissue-specific requirements by targeted blockade and rescue.
L. Cherbas, X. Hu, I. Zhimulev, E. Belyaeva, and P. Cherbas (2003)
Development 130, 271-284
   Abstract »    Full Text »    PDF »
Thyroid Hormone Receptor DNA Binding Is Required for Both Positive and Negative Gene Regulation.
N. Shibusawa, A. N. Hollenberg, and F. E. Wondisford (2003)
J. Biol. Chem. 278, 732-738
   Abstract »    Full Text »    PDF »
Estrogen and Thyroid Hormone Receptor Interactions: Physiological Flexibility by Molecular Specificity.
N. Vasudevan, S. Ogawa, and D. Pfaff (2002)
Physiol Rev 82, 923-944
   Abstract »    Full Text »    PDF »
Isolation and Functional Analysis of the Mouse RXRgamma 1 Gene Promoter in Anterior Pituitary Cells.
N. B. McDermott, D. F. Gordon, C. A. Kramer, Q. Liu, E. Linney, W. M. Wood, and B. R. Haugen (2002)
J. Biol. Chem. 277, 36839-36844
   Abstract »    Full Text »    PDF »
The Amino Acid Residues Asparagine 354 and Isoleucine 372 of Human Farnesoid X Receptor Confer the Receptor with High Sensitivity to Chenodeoxycholate.
J. Cui, T. S. Heard, J. Yu, J.-L. Lo, L. Huang, Y. Li, J. M. Schaeffer, and S. D. Wright (2002)
J. Biol. Chem. 277, 25963-25969
   Abstract »    Full Text »    PDF »
Feedback on Hypothalamic TRH Transcription Is Dependent on Thyroid Hormone Receptor N Terminus.
H. Guissouma, S. M. Dupre, N. Becker, E. Jeannin, I. Seugnet, B. Desvergne, and B. A. Demeneix (2002)
Mol. Endocrinol. 16, 1652-1666
   Abstract »    Full Text »    PDF »
Methylation and Inactivation of Estrogen, Progesterone, and Androgen Receptors in Prostate Cancer.
M. Sasaki, Y. Tanaka, G. Perinchery, A. Dharia, I. Kotcherguina, S. i. Fujimoto, and R. Dahiya (2002)
J Natl Cancer Inst 94, 384-390
   Abstract »    Full Text »    PDF »
An Isoform of Branched-chain Aminotransferase Is a Novel Co-repressor for Thyroid Hormone Nuclear Receptors.
H.-M. Lin, M. Kaneshige, L. Zhao, X. Zhang, J. A. Hanover, and S.-y. Cheng (2001)
J. Biol. Chem. 276, 48196-48205
   Abstract »    Full Text »    PDF »
Minireview: Genomic Organization of the Human ER{alpha} Gene Promoter Region.
M. Kos, G. Reid, S. Denger, and F. Gannon (2001)
Mol. Endocrinol. 15, 2057-2063
   Abstract »    Full Text »    PDF »
Nuclear Corepressor and Silencing Mediator of Retinoic and Thyroid Hormone Receptors Corepressor Expression Is Incompatible with T3-Dependent TRH Regulation.
N. Becker, I. Seugnet, H. Guissouma, S. M. Dupre, and B. A. Demeneix (2001)
Endocrinology 142, 5321-5331
   Abstract »    Full Text »    PDF »
Physiological and Molecular Basis of Thyroid Hormone Action.
P. M. Yen (2001)
Physiol Rev 81, 1097-1142
   Abstract »    Full Text »    PDF »
Developmental expression analysis of thyroid hormone receptor isoforms reveals new insights into their essential functions in cardiac and skeletal muscles.
P. WHITE, K. A. BURTON, A. L. FOWDEN, and M. J. DAUNCEY (2001)
FASEB J 15, 1367-1376
   Abstract »    Full Text »    PDF »
Regulation of Microglial Development: A Novel Role for Thyroid Hormone.
F. R. S. Lima, A. Gervais, C. Colin, M. Izembart, V. M. Neto, and M. Mallat (2001)
J. Neurosci. 21, 2028-2038
   Abstract »    Full Text »    PDF »
Regulation of prohormone convertase 1 (PC1) by thyroid hormone.
Q.-L. Li, E. Jansen, G. A. Brent, and T. C. Friedman (2001)
Am J Physiol Endocrinol Metab 280, E160-E170
   Abstract »    Full Text »    PDF »
Retinoic Acids and Thyroid Hormone Act Synergistically with Dexamethasone to Increase Growth Hormone-Releasing Hormone Receptor Messenger Ribonucleic Acid Expression.
H. Nogami, M. Matsubara, T. Harigaya, M. Katayama, and K. Kawamura (2000)
Endocrinology 141, 4396-4401
   Abstract »    Full Text »    PDF »
Cloning and Characterization of Two Novel Thyroid Hormone Receptor beta Isoforms.
G. R. Williams (2000)
Mol. Cell. Biol. 20, 8329-8342
   Abstract »    Full Text »
Interactions between the Prohormone Convertase 2 Promoter and the Thyroid Hormone Receptor.
Q.-L. Li, E. Jansen, G. A. Brent, S. Naqvi, J. F. Wilber, and T. C. Friedman (2000)
Endocrinology 141, 3256-3266
   Abstract »    Full Text »    PDF »
Developmental Expression of Thyroid Hormone Receptors in the Rat Testis.
J. J. Buzzard, J. R. Morrison, M. K. O'Bryan, Q. Song, and N. G. Wreford (2000)
Biol Reprod 62, 664-669
   Abstract »    Full Text »
Transcriptional Anti-repression. THYROID HORMONE RECEPTOR beta -2 RECRUITS SMRT COREPRESSOR BUT INTERFERES WITH SUBSEQUENT ASSEMBLY OF A FUNCTIONAL COREPRESSOR COMPLEX.
Z. Yang, S.-H. Hong, and M. L. Privalsky (1999)
J. Biol. Chem. 274, 37131-37138
   Abstract »    Full Text »    PDF »
Proliferation of Bone Marrow Pro-B Cells Is Dependent on Stimulation by the Pituitary/Thyroid Axis.
M. P. Foster, E. Montecino-Rodriguez, and K. Dorshkind (1999)
J. Immunol. 163, 5883-5890
   Abstract »    Full Text »    PDF »
Mice devoid of all known thyroid hormone receptors are viable but exhibit disorders of the pituitary-thyroid axis, growth, and bone maturation.
S. Göthe, Z. Wang, L. Ng, J. M. Kindblom, A. C. Barros, C. Ohlsson, B. Vennström, and D. Forrest (1999)
Genes & Dev. 13, 1329-1341
   Abstract »    Full Text »
Thyroid hormones modulate zinc transport activity of rat intestinal and renal brush-border membrane.
R. Prasad, V. Kumar, R. Kumar, and K. P. Singh (1999)
Am J Physiol Endocrinol Metab 276, E774-E782
   Abstract »    Full Text »    PDF »
Regulation of the mdm2 Oncogene by Thyroid Hormone Receptor.
J.-S. Qi, Y. Yuan, V. Desai-Yajnik, and H. H. Samuels (1999)
Mol. Cell. Biol. 19, 864-872
   Abstract »    Full Text »    PDF »
Thyroid hormone receptor beta -dependent expression of a potassium conductance in inner hair cells at the onset of hearing.
A. Rusch, L. C. Erway, D. Oliver, B. Vennstrom, and D. Forrest (1998)
PNAS 95, 15758-15762
   Abstract »    Full Text »    PDF »
Physiological regulation of hypothalamic TRH transcription in vivo is T3 receptor isoform specific.
H. Guissouma, M. T. Ghorbel, I. Seugnet, T. Ouatas, and B. A. Demeneix (1998)
FASEB J 12, 1755-1764
   Abstract »    Full Text »
p21WAF1 is required for butyrate-mediated growth inhibition of human colon cancer cells.
S. Y. Archer, S. Meng, A. Shei, and R. A. Hodin (1998)
PNAS 95, 6791-6796
   Abstract »    Full Text »    PDF »
A Novel TR{beta} Mutation (R383H) in Resistance to Thyroid Hormone Syndrome Predominantly Impairs Corepressor Release and Negative Transcriptional Regulation.
R. J. Clifton-Bligh, F. de Zegher, R. L. Wagner, T. N. Collingwood, I. Francois, M. Van Helvoirt, R. J. Fletterick, and V. K. K. Chatterjee (1998)
Mol. Endocrinol. 12, 609-621
   Abstract »    Full Text »
A Novel Multifunctional Motif in the Amino-terminal A/B Domain of T3Ralpha Modulates DNA Binding and Receptor Dimerization.
E. Hadzic, I. Habeos, B. M. Raaka, and H. H. Samuels (1998)
J. Biol. Chem. 273, 10270-10278
   Abstract »    Full Text »    PDF »
Thyroid hormone affects Schwann cell and oligodendrocyte gene expression at the glial transition zone of the VIIIth nerve prior to cochlea function.
M Knipper, C Bandtlow, L Gestwa, I Kopschall, K Rohbock, B Wiechers, H. Zenner, and U Zimmermann (1998)
Development 125, 3709-3718
   Abstract »    PDF »
Differential Transactivation by Two Isoforms of the Orphan Nuclear Hormone Receptor CAR.
H.-S. Choi, M. Chung, I. Tzameli, D. Simha, Y.-K. Lee, W. Seol, and D. D. Moore (1997)
J. Biol. Chem. 272, 23565-23571
   Abstract »    Full Text »    PDF »
Deletion of the Thyroid Hormone {beta}1 Receptor Increases Basal and Triiodothyronine-Induced Growth Hormone Messenger Ribonucleic Acid in GH3 Cells.
S. G. Ball, M. Ikeda, and W. W. Chin (1997)
Endocrinology 138, 3125-3132
   Abstract »    Full Text »    PDF »
3,5-Diiodo-L-Thyronine Stimulates Type 1 5'Deiodinase Activity in Rat Anterior Pituitaries in Vivo and in Reaggregate Cultures and GH3 Cells in Vitro.
A. Baur, K. Bauer, H. Jarry, and J. Kohrle (1997)
Endocrinology 138, 3242-3248
   Abstract »    Full Text »    PDF »
Identification of a Nuclear Protein from Rat Developing Brain as Heterodimerization Partner with Thyroid Hormone Receptor-{beta}.
B. Huo, B. Dozin, and V. M. Nikodem (1997)
Endocrinology 138, 3283-3289
   Abstract »    Full Text »    PDF »
Isoform Variable Action among Thyroid Hormone Receptor Mutants Provides Insight into Pituitary Resistance to Thyroid Hormone.
J. D. Safer, M. F. Langlois, R. Cohen, T. Monden, D. John-Hope, J. Madura, A. N. Hollenberg, and F. E. Wondisford (1997)
Mol. Endocrinol. 11, 16-26
   Abstract »    Full Text »
Function of Nuclear Co-repressor Protein on Thyroid Hormone Response Elements Is Regulated by the Receptor A/B Domain.
A. N. Hollenberg, T. Monden, J. P. Madura, K. Lee, and F. E. Wondisford (1996)
J. Biol. Chem. 271, 28516-28520
   Abstract »    Full Text »    PDF »
Negative Regulation of the Gene for the Preprothyrotropin-releasing Hormone from the Mouse by Thyroid Hormone Requires Additional Factors in Conjunction with Thyroid Hormone Receptors.
T. Satoh, M. Yamada, T. Iwasaki, and M. Mori (1996)
J. Biol. Chem. 271, 27919-27926
   Abstract »    Full Text »    PDF »
Thyroid Hormone Receptor beta 2 Promoter Activity in Pituitary Cells Is Regulated by Pit-1.
W. M. Wood, J. M. Dowding, T. M. Bright, M. T. McDermott, B. R. Haugen, D. F. Gordon, and E. C. Ridgway (1996)
J. Biol. Chem. 271, 24213-24220
   Abstract »    Full Text »    PDF »
Impaired Action of Thyroid Hormone Associated with Smoking in Women with Hypothyroidism.
B. Muller, H. Zulewski, P. Huber, J. G. Ratcliffe, and J.-J. Staub (1995)
N. Engl. J. Med. 333, 964-969
   Abstract »    Full Text »    PDF »
Ligand-independent and -dependent Functions of Thyroid Hormone Receptor Isoforms Depend upon Their Distinct Amino Termini.
A. N. Hollenberg, T. Monden, and F. E. Wondisford (1995)
J. Biol. Chem. 270, 14274-14280
   Abstract »    Full Text »    PDF »
A novel role for thyroid hormone, glucocorticoids and retinoic acid in timing oligodendrocyte development.
B. Barres, M. Lazar, and M. Raff (1994)
Development 120, 1097-1108
   Abstract »    PDF »
Attention Deficit-Hyperactivity Disorder in People with Generalized Resistance to Thyroid Hormone.
P. Hauser, A. J. Zametkin, P. Martinez, B. Vitiello, J. A. Matochik, J. A. Mixson, and B. D. Weintraub (1993)
N. Engl. J. Med. 328, 997-1001
   Abstract »    Full Text »
A correlation of thyroid hormone receptor gene expression with amphibian metamorphosis..
Y Yaoita and D D Brown (1990)
Genes & Dev. 4, 1917-1924
   Abstract »    PDF »
The Pit-1beta Domain Dictates Active Repression and Alteration of Histone Acetylation of the Proximal Prolactin Promoter.
S. E. Diamond and A. Gutierrez-Hartmann (2000)
J. Biol. Chem. 275, 30977-30986
   Abstract »    Full Text »    PDF »
Chromatin Remodeling by the Thyroid Hormone Receptor in Regulation of the Thyroid-stimulating Hormone alpha -Subunit Promoter.
T. N. Collingwood, F. D. Urnov, V. K. K. Chatterjee, and A. P. Wolffe (2001)
J. Biol. Chem. 276, 34227-34234
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)