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Science 7 April 1989:
Vol. 244. no. 4900, pp. 41 - 47
DOI: 10.1126/science.2649979
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Articles

Science, Vol 244, Issue 4900, 41-47
Copyright © 1989 by American Association for the Advancement of Science

articles

The purine path to chemotherapy

GB Elion

Wellcome Research Laboratories, Burroughs Wellcome Company, Research Triangle Park, NC 27709.

Research on antimetabolites of nucleic acid purines led to drugs for the treatment of acute leukemia (6-mercaptopurine and thioguanine), gout and hyperuricemia (allopurinol), and herpesvirus infections (acyclovir), and for the prevention of organ transplant rejection (azathioprine).


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Recombinant Microorganisms as Tools for High Throughput Screening for Nonantibiotic Compounds.
R. D. Klein and T. G. Geary (1997)
J Biomol Screen 2, 41-49
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Cloning, Characterization, and Modeling of Mouse and Human Guanylate Kinases.
W. A. Brady, M. S. Kokoris, M. Fitzgibbon, and M. E. Black (1996)
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Emerging treatments in multiple sclerosis: Azathioprine and Mof etil.
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Multiple Sclerosis 1, 379-384
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Localization of GAR transformylase in Escherichia coli and mammalian cells.
L. T. Gooljarsingh, J. Ramcharan, S. Gilroy, and S. J. Benkovic (2001)
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