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Science 31 March 1989:
Vol. 243. no. 4899, pp. 1728 - 1730
DOI: 10.1126/science.2648574
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Articles

Science, Vol 243, Issue 4899, 1728-1730
Copyright © 1989 by American Association for the Advancement of Science

articles

The pathway of infection of Autographa californica nuclear polyhedrosis virus in an insect host

BA Keddie, GW Aponte, and LE Volkman

Department of Entomology, University of California, Berkeley.

An immunohistochemical study was conducted to detect the temporal infection sequence of Autographa californica M nuclear polyhedrosis virus in Trichoplusia ni larvae. Staining patterns indicated that the initial infection occurred in the midgut, simultaneously in columnar epithelial and regenerative cells, but that subsequently this tissue recovered. A major envelope glycoprotein stained in a polar fashion when it was expressed in columnar epithelial cells, but not when expressed in other cells types. Systemic infection was mediated by free virus for some tissues whereas infected hemocytes appeared to spread virus to other tissues by an unknown mechanism. A cell to cell spread within several tissues was detected. These results have important implications for baculoviruses engineered for improving their pesticide potential.


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Bombyx mori nucleopolyhedrovirus-based surface display system for recombinant proteins.
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Actin Rearrangement-Inducing Factor of Baculoviruses Is Tyrosine Phosphorylated and Colocalizes to F-Actin at the Plasma Membrane.
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A GP64-Null Baculovirus Pseudotyped with Vesicular Stomatitis Virus G Protein.
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J. Virol. 75, 2544-2556
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Central Role of Hemocytes in Autographa californica M Nucleopolyhedrovirus Pathogenesis in Heliothis virescens and Helicoverpa zea.
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J. Virol. 75, 996-1003
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Filamentous actin is required for lepidopteran nucleopolyhedrovirus progeny production.
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J. Gen. Virol. 81, 1881-1888
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Mutational Analysis of the N-Linked Glycans on Autographa californica Nucleopolyhedrovirus gp64.
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