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Science 31 March 1989:
Vol. 243. no. 4899, pp. 1721 - 1724
DOI: 10.1126/science.2467382

Articles

Science, Vol 243, Issue 4899, 1721-1724
Copyright © 1989 by American Association for the Advancement of Science


articles

Ethanol inhibits NMDA-activated ion current in hippocampal neurons

DM Lovinger, G White, and FF Weight

Section of Electrophysiology, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852.

The ion current induced by the glutamate receptor agonist N-methyl-D-aspartate (NMDA) in voltage-clamped hippocampal neurons was inhibited by ethanol (EtOH). Inhibition increased in a concentration-dependent manner over the range 5 to 50 mM, a range that also produces intoxication. The amplitude of the NMDA-activated current was reduced 61 percent by 50 mM EtOH; in contrast, this concentration of EtOH reduced the amplitude of current activated by the glutamate receptor agonists kainate and quisqualate by only 18 and 15 percent, respectively. The potency for inhibition of the NMDA-activated current by several alcohols is linearly related to their intoxicating potency, suggesting that alcohol-induced inhibition of responses to NMDA receptor activation may contribute to the neural and cognitive impairments associated with intoxication.


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J. Biol. Chem. 276, 44729-44735
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Science. ISSN 0036-8075 (print), 1095-9203 (online)