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Science 31 March 1989:
Vol. 243. no. 4899, pp. 1716 - 1718
DOI: 10.1126/science.2564701
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Articles

Science, Vol 243, Issue 4899, 1716-1718
Copyright © 1989 by American Association for the Advancement of Science

articles

In vivo modulation of cytolytic activity and Thy-1 expression in TCR-gamma delta+ intraepithelial lymphocytes

L Lefrancois and T Goodman

Department of Cell Biology, Upjohn Company, Kalamazoo, MI 49001.

Although the functional aspects of the alpha beta T cell antigen receptor (TCR) found on most peripheral T cells are well described, the function of the gamma delta TCR remains unclear. Murine intraepithelial lymphocytes (IEL) of the small intestine are CD8+, express the gamma delta TCR, and are constitutively lytic. Fresh IEL from germ-free mice had no lytic activity. Moreover, whereas IEL from normal mice are 30 to 50 percent Thy-1+, IEL from germ-free did not express Thy-1. Acclimation of germ-free mice to nonsterile conditions resulted in the generation of Thy-1+ IEL and induction of lytic activity. Thus CD8+ TCR-gamma delta IEL were regulated by externally derived stimuli via a specific functional interaction between IEL and gut-associated antigens.


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