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Science 31 March 1989:
Vol. 243. no. 4899, pp. 1713 - 1716
DOI: 10.1126/science.2538925
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Articles

Science, Vol 243, Issue 4899, 1713-1716
Copyright © 1989 by American Association for the Advancement of Science

articles

Mutations in a protein kinase C homolog confer phorbol ester resistance on Caenorhabditis elegans

Y Tabuse, K Nishiwaki, and J Miwa

Fundamental Research Laboratories, NEC Corporation, Kawasaki, Kanagawa, Japan.

The tpa-1 gene mediates the action of tumor-promoting phorbol esters in the nematode Caenorhabditis elegans. A genomic fragment that constitutes a portion of the tpa-1 gene was cloned by Tc1 transposon tagging and was used as a probe to screen a nematode complementary DNA library. One of the isolated complementary DNA clones had a nucleotide sequence that predicts a polypeptide of 526 amino acids. The predicted amino acid sequence revealed that the predicted tpa-1 protein sequence is highly similar to protein kinase C molecules from various animals, including man.


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