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Science 31 March 1989:
Vol. 243. no. 4899, pp. 1689 - 1694
DOI: 10.1126/science.2494701
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Articles

Science, Vol 243, Issue 4899, 1689-1694
Copyright © 1989 by American Association for the Advancement of Science

articles

Leucine repeats and an adjacent DNA binding domain mediate the formation of functional cFos-cJun heterodimers

R Turner and R Tjian

Howard Hughes Medical Institute, Department of Biochemistry, University of California, Berkeley 94720.

The discovery that the AP-1 family of enhancer binding factors includes a complex of the cellular Fos (cFos) and cellular Jun (cJun) proteins established a direct and important link between oncogenesis and transcriptional regulation. Homodimeric cJun protein synthesized in vitro is capable of binding selectively to AP-1 recognition sites, whereas the cFos polypeptide is not. When cotranslated, the cFos and cJun proteins can form a stable, heterodimeric complex with the DNA binding properties of AP-1/cJun. The related proteins Jun B and vJun are also able to form DNA binding complexes with cFos. Directed mutagenesis of the cFos protein reveals that a leucine repeat structure is required for binding to cJun, in a manner consistent with the proposed function of the "leucine zipper." A novel domain adjacent to, but distinct from, the leucine repeat of cFos is required for DNA binding by cFos-cJun heterodimers. Thus experimental evidence is presented that leucine repeats can mediate complex formation between heterologous proteins and that promotes further understanding of the molecular mechanisms underlying the function of two proto-oncogene products.


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Methylation-sensitive sequence-specific DNA binding by the c-Myc basic region.
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E Gizang-Ginsberg and E B Ziff (1990)
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TFE3: a helix-loop-helix protein that activates transcription through the immunoglobulin enhancer muE3 motif..
H Beckmann, L K Su, and T Kadesch (1990)
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Mutations of the adenylyl cyclase gene that block RAS function in Saccharomyces cerevisiae.
J Field, H. Xu, T Michaeli, R Ballester, P Sass, M Wigler, and J Colicelli (1990)
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T. Curran, C. Abate, D.R. Cohen, P.F. Macgregor, F.J. Rauscher III, J.L. Sonnenberg, J.A. Connor, and J.I. Morgan (1990)
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