Related Content
Search Google Scholar for:
|
|
Science 31 March 1989: Vol. 243. no. 4899, pp. 1681 - 1688 DOI: 10.1126/science.2494700
|
|
Articles
Science, Vol 243, Issue 4899, 1681-1688
Copyright © 1989 by American Association for the Advancement of Science
The DNA binding domain of the rat liver nuclear protein C/EBP is bipartite
WH Landschulz,
PF Johnson,
and
SL McKnight
Howard Hughes Medical Institute, Carnegie Institution of Washington, Department of Embryology, Baltimore, MD 21210.
C/EBP is a rat liver nuclear protein capable of sequence-specific interaction with DNA. The DNA sequences to which C/EBP binds in vitro have been implicated in the control of messenger RNA synthesis. It has therefore been predicted that C/EBP will play a role in regulating gene expression in mammalian cells. The region of the C/EBP polypeptide required for direct interaction with DNA has been identified and shown to bear amino acid sequence relatedness with the product of the myc, fos, and jun proto-oncogenes. The arrangement of these related amino acid sequences led to the prediction of a new structural motif, termed the "leucine zipper," that plays a role in facilitating sequence-specific interaction between protein and DNA. Experimental tests now provide support for the leucine zipper hypothesis.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- NF-{kappa}B p50 Regulates C/EBP{alpha} Expression and Inflammatory Cytokine-Induced Neutrophil Production.
- D. Wang, I. Paz-Priel, and A. D. Friedman (2009)
J. Immunol.
182, 5757-5762
| Abstract »
| Full Text »
| PDF »
- C/EBP Homology Protein (CHOP) Interacts with Activating Transcription Factor 4 (ATF4) and Negatively Regulates the Stress-dependent Induction of the Asparagine Synthetase Gene.
- N. Su and M. S. Kilberg (2008)
J. Biol. Chem.
283, 35106-35117
| Abstract »
| Full Text »
| PDF »
- A haplotype of human angiotensinogen gene containing -217A increases blood pressure in transgenic mice compared with -217G.
- S. Jain, G. Vinukonda, S. N. Fiering, and A. Kumar (2008)
Am J Physiol Regulatory Integrative Comp Physiol
295, R1849-R1857
| Abstract »
| Full Text »
| PDF »
- Genomic Analysis Reveals Mycoplasma pneumoniae Repetitive Element 1-Mediated Recombination in a Clinical Isolate.
- O. Musatovova, T. R. Kannan, and J. B. Baseman (2008)
Infect. Immun.
76, 1639-1648
| Abstract »
| Full Text »
| PDF »
- Tamoxifen Induction of CCAAT Enhancer-binding Protein {alpha} Is Required for Tamoxifen-induced Apoptosis.
- J. Cheng, D. V. Yu, J.-H. Zhou, and D. J. Shapiro (2007)
J. Biol. Chem.
282, 30535-30543
| Abstract »
| Full Text »
| PDF »
- Methylation-Controlled J Protein Promotes c-Jun Degradation To Prevent ABCB1 Transporter Expression.
- K. M. Hatle, W. Neveu, O. Dienz, S. Rymarchyk, R. Barrantes, S. Hale, N. Farley, K. M. Lounsbury, J. P. Bond, D. Taatjes, et al. (2007)
Mol. Cell. Biol.
27, 2952-2966
| Abstract »
| Full Text »
| PDF »
- Glucocorticoid-induced leucine zipper (GILZ)/NF-{kappa}B interaction: role of GILZ homo-dimerization and C-terminal domain.
- B. D. Marco, M. Massetti, S. Bruscoli, A. Macchiarulo, R. D. Virgilio, E. Velardi, V. Donato, G. Migliorati, and C. Riccardi (2007)
Nucleic Acids Res.
35, 517-528
| Abstract »
| Full Text »
| PDF »
- Interactions between c-Jun, Nuclear Factor 1, and JC Virus Promoter Sequences: Implications for Viral Tropism.
- V. Ravichandran, B. F. Sabath, P. N. Jensen, S. A. Houff, and E. O. Major (2006)
J. Virol.
80, 10506-10513
| Abstract »
| Full Text »
| PDF »
- CCAAT/enhancer binding proteins alpha and epsilon cooperate with all-trans retinoic acid in therapy but differ in their antileukemic activities.
- Y.-J. Lee, L. C. Jones, N. A. Timchenko, D. Perrotti, D. G. Tenen, and S. C. Kogan (2006)
Blood
108, 2416-2419
| Abstract »
| Full Text »
| PDF »
- CCAAT/enhancer-binding protein {delta} activates the Runx2-mediated transcription of mouse osteocalcin II promoter..
- C. S. Shin, M. J. Jeon, J.-Y. Yang, S.-J. Her, D. Kim, S. W. Kim, and S. Y. Kim (2006)
J. Mol. Endocrinol.
36, 531-546
| Abstract »
| Full Text »
| PDF »
- Bidirectional regulation of monocyte chemoattractant protein-1 gene at distinct sites of its promoter by nitric oxide in vascular smooth muscle cells.
- K.-i. Kodama, Y. Nishio, O. Sekine, Y. Sato, K. Egawa, H. Maegawa, and A. Kashiwagi (2005)
Am J Physiol Cell Physiol
289, C582-C590
| Abstract »
| Full Text »
| PDF »
- Interaction between GATA and the C/EBP Family of Transcription Factors Is Critical in GATA-Mediated Suppression of Adipocyte Differentiation.
- Q. Tong, J. Tsai, G. Tan, G. Dalgin, and G. S. Hotamisligil (2005)
Mol. Cell. Biol.
25, 706-715
| Abstract »
| Full Text »
| PDF »
- The CCAAT Enhancer-binding Protein (C/EBP){beta} and Nrf1 Interact to Regulate Dentin Sialophosphoprotein (DSPP) Gene Expression during Odontoblast Differentiation.
- K. Narayanan, A. Ramachandran, M. C. Peterson, J. Hao, A.-B. Kolsto, A. D. Friedman, and A. George (2004)
J. Biol. Chem.
279, 45423-45432
| Abstract »
| Full Text »
| PDF »
- Dimerization specificity of all 67 B-ZIP motifs in Arabidopsis thaliana: a comparison to Homo sapiens B-ZIP motifs.
- C. D. Deppmann, A. Acharya, V. Rishi, B. Wobbes, S. Smeekens, E. J. Taparowsky, and C. Vinson (2004)
Nucleic Acids Res.
32, 3435-3445
| Abstract »
| Full Text »
| PDF »
- Analysis of Transmembrane Domain 2 of Rat Serotonin Transporter by Cysteine Scanning Mutagenesis.
- Y. Sato, Y.-W. Zhang, A. Androutsellis-Theotokis, and G. Rudnick (2004)
J. Biol. Chem.
279, 22926-22933
| Abstract »
| Full Text »
| PDF »
- A Role for CCAAT/Enhancer-Binding Protein {beta} in the Basal Regulation of the Distal-Less 3 Gene Promoter in Placental Cells.
- M. P. Holland, S. P. Bliss, K. A. Berghorn, and M. S. Roberson (2004)
Endocrinology
145, 1096-1105
| Abstract »
| Full Text »
| PDF »
- Cross-talk between regulators of myeloid development: C/EBP{alpha} binds and activates the promoter of the PU.1 gene.
- T. Kummalue and A. D. Friedman (2003)
J. Leukoc. Biol.
74, 464-470
| Abstract »
| Full Text »
| PDF »
- Transcription activation function of C/EBP{alpha} is required for induction of granulocytic differentiation.
- K. Keeshan, G. Santilli, F. Corradini, D. Perrotti, and B. Calabretta (2003)
Blood
102, 1267-1275
| Abstract »
| Full Text »
| PDF »
- 5-Lipoxygenase-activating Protein Gene Expression. KEY ROLE OF CCAAT/ENHANCER-BINDING PROTEINS (C/EBP) IN CONSTITUTIVE AND TUMOR NECROSIS FACTOR (TNF) alpha -INDUCED EXPRESSION IN THP-1 CELLS.
- K. V. Reddy, K. J. Serio, C. R. Hodulik, and T. D. Bigby (2003)
J. Biol. Chem.
278, 13810-13818
| Abstract »
| Full Text »
| PDF »
- Regulation of the angiopoietin-like protein 3 gene by LXR.
- R. Kaplan, T. Zhang, M. Hernandez, F. X. Gan, S. D. Wright, M. G. Waters, and T.-Q. Cai (2003)
J. Lipid Res.
44, 136-143
| Abstract »
| Full Text »
| PDF »
- Downregulation of c-Jun Expression by Transcription Factor C/EBP{alpha} Is Critical for Granulocytic Lineage Commitment.
- J. Rangatia, R. K. Vangala, N. Treiber, P. Zhang, H. Radomska, D. G. Tenen, W. Hiddemann, and G. Behre (2002)
Mol. Cell. Biol.
22, 8681-8694
| Abstract »
| Full Text »
| PDF »
- Ethanol Induction of Class I Alcohol Dehydrogenase Expression in the Rat Occurs through Alterations in CCAAT/Enhancer Binding Proteins beta and gamma.
- L. He, M. J. J. Ronis, and T. M. Badger (2002)
J. Biol. Chem.
277, 43572-43577
| Abstract »
| Full Text »
| PDF »
- Angiotensinogen Gene Polymorphism at -217 Affects Basal Promoter Activity and Is Associated with Hypertension in African-Americans.
- S. Jain, X. Tang, C. S. Narayanan, Y. Agarwal, S. M. Peterson, C. D. Brown, J. Ott, and A. Kumar (2002)
J. Biol. Chem.
277, 36889-36896
| Abstract »
| Full Text »
| PDF »
- Classification of Human B-ZIP Proteins Based on Dimerization Properties.
- C. Vinson, M. Myakishev, A. Acharya, A. A. Mir, J. R. Moll, and M. Bonovich (2002)
Mol. Cell. Biol.
22, 6321-6335
| Full Text »
| PDF »
- B-ZIP Proteins Encoded by the Drosophila Genome: Evaluation of Potential Dimerization Partners.
- J. Fassler, D. Landsman, A. Acharya, J. R. Moll, M. Bonovich, and C. Vinson (2002)
Genome Res.
12, 1190-1200
| Abstract »
| Full Text »
| PDF »
- Characterization of a New Upstream GnRH Receptor Promoter in Human Ovarian Granulosa-Luteal Cells.
- C. K. Cheng, C. M. Yeung, B. K. C. Chow, and P. C. K. Leung (2002)
Mol. Endocrinol.
16, 1552-1564
| Abstract »
| Full Text »
| PDF »
- Expression of C/EBPbeta from the C/ebpalpha gene locus is sufficient for normal hematopoiesis in vivo.
- L. C. Jones, M.-L. Lin, S.-S. Chen, U. Krug, W.-K. Hofmann, S. Lee, Y.-H. Lee, and H. P. Koeffler (2002)
Blood
99, 2032-2036
| Abstract »
| Full Text »
| PDF »
- Electrostatic control of half-site spacing preferences by the cyclic AMP response element-binding protein CREB.
- J. K. Montclare, L. S. Sloan, and A. Schepartz (2001)
Nucleic Acids Res.
29, 3311-3319
| Abstract »
| Full Text »
| PDF »
- A dual role for substrate S-adenosyl-L-methionine in the methylation reaction with bacteriophage T4 Dam DNA-[N6-adenine]-methyltransferase.
- E. G. Malygin, A. A. Evdokimov, V. V. Zinoviev, L. G. Ovechkina, W. M. Lindstrom, N. O. Reich, S. L. Schlagman, and S. Hattman (2001)
Nucleic Acids Res.
29, 2361-2369
| Abstract »
| Full Text »
| PDF »
- Gonad-Specific Expression of Two Novel Chicken Complementary DNA Isoforms.
- H. Kim, S. You, J. Farris, L. K. Foster, Y.-J. Choi, and D. N. Foster (2001)
Biol Reprod
64, 1473-1480
| Abstract »
| Full Text »
- The Role of C/EBP{{varepsilon}} in the Terminal Stages of Granulocyte Differentiation.
- J. A. Lekstrom-Himes (2001)
Stem Cells
19, 125-133
| Abstract »
| Full Text »
- Representational difference analysis using myeloid cells from C/EBPepsilon deletional mice.
- T. Kubota, S. Kawano, D. Y. Chih, Y. Hisatake, A. M. Chumakov, H. Taguchi, and H. P. Koeffler (2000)
Blood
96, 3953-3957
| Abstract »
| Full Text »
| PDF »
- Zhangfei: a second cellular protein interacts with herpes simplex virus accessory factor HCF in a manner similar to Luman and VP16.
- R. Lu and V. Misra (2000)
Nucleic Acids Res.
28, 2446-2454
| Abstract »
| Full Text »
| PDF »
- The activity of the Epstein-Barr virus BamHI W promoter in B cells is dependent on the binding of CREB/ATF factors.
- H. Kirby, A. Rickinson, and A. Bell (2000)
J. Gen. Virol.
81, 1057-1066
| Abstract »
| Full Text »
- Cloning of a Mammalian Transcriptional Activator That Binds Unmethylated CpG Motifs and Shares a CXXC Domain with DNA Methyltransferase, Human Trithorax, and Methyl-CpG Binding Domain Protein 1.
- K. Shin Voo, D. L. Carlone, B. M. Jacobsen, A. Flodin, and D. G. Skalnik (2000)
Mol. Cell. Biol.
20, 2108-2121
| Abstract »
| Full Text »
- Inhibition of Homodimerization of Poly(ADP-ribose) Polymerase by Its C-terminal Cleavage Products Produced during Apoptosis.
- J. W. Kim, K. Kim, K. Kang, and C. O. Joe (2000)
J. Biol. Chem.
275, 8121-8125
| Abstract »
| Full Text »
| PDF »
- Regulation of Myosin Phosphatase by a Specific Interaction with cGMP- Dependent Protein Kinase I.
- H. K. Surks, N. Mochizuki, Y. Kasai, S. P. Georgescu, K. M. Tang, M. Ito, T. M. Lincoln, and M. E. Mendelsohn (1999)
Science
286, 1583-1587
| Abstract »
| Full Text »
- p53 Negatively Regulates cdc2 Transcription via the CCAAT-binding NF-Y Transcription Factor.
- J. Yun, H.-D. Chae, H. E. Choy, J. Chung, H.-S. Yoo, M.-H. Han, and D. Y. Shin (1999)
J. Biol. Chem.
274, 29677-29682
| Abstract »
| Full Text »
| PDF »
- CCAAT/Enhancer Binding Protein varepsilon Is Critical for Effective Neutrophil-Mediated Response to Inflammatory Challenge.
- J. Lekstrom-Himes and K. G. Xanthopoulos (1999)
Blood
93, 3096-3105
| Abstract »
| Full Text »
| PDF »
- CCAAT/Enhancer-binding Protein delta Is a Critical Regulator of Insulin-like Growth Factor-I Gene Transcription in Osteoblasts.
- Y. Umayahara, J. Billiard, C. Ji, M. Centrella, T. L. McCarthy, and P. Rotwein (1999)
J. Biol. Chem.
274, 10609-10617
| Abstract »
| Full Text »
| PDF »
- Transcriptional Repression of Human Hepatitis B Virus Genes by a bZIP Family Member, E4BP4.
- C.-K. Lai and L.-P. Ting (1999)
J. Virol.
73, 3197-3209
| Abstract »
| Full Text »
- C/EBPalpha Regulates Formation of S-Phase-Specific E2F-p107 Complexes in Livers of Newborn Mice.
- N. A. Timchenko, M. Wilde, and G. J. Darlington (1999)
Mol. Cell. Biol.
19, 2936-2945
| Abstract »
| Full Text »
| PDF »
- Isoform-Specific Regulation of the CCAAT/Enhancer-Binding Protein Family of Transcription Factors by 3',5'-Cyclic Adenosine Monophosphate in Sertoli Cells.
- L. M. Grønning, M. K. Dahle, K. A. Taskén, S. Enerbäck, L. Hedin, K. Taskén, and H. K. Knutsen (1999)
Endocrinology
140, 835-843
| Abstract »
| Full Text »
- Biological Role of the CCAAT/Enhancer-binding Protein Family of Transcription Factors.
- J. Lekstrom-Himes and K. G. Xanthopoulos (1998)
J. Biol. Chem.
273, 28545-28548
| Abstract »
| Full Text »
| PDF »
- Multiple Functional Domains of AML1: PU.1 and C/EBPalpha Synergize with Different Regions of AML1.
- M. S. Petrovick, S. W. Hiebert, A. D. Friedman, C. J. Hetherington, D. G. Tenen, and D.-E. Zhang (1998)
Mol. Cell. Biol.
18, 3915-3925
| Abstract »
| Full Text »
- Human Translocation Liposarcoma-CCAAT/Enhancer Binding Protein (C/EBP) Homologous Protein (TLS-CHOP) Oncoprotein Prevents Adipocyte Differentiation by Directly Interfering with C/EBPbeta Function.
- G. Adelmant, J. D. Gilbert, and S. O. Freytag (1998)
J. Biol. Chem.
273, 15574-15581
| Abstract »
| Full Text »
| PDF »
- Identification of Transcriptional Activation and Repression Domains in Human CCAAT/Enhancer-binding Protein epsilon.
- E. A. Williamson, H. N. Xu, A. F. Gombart, W. Verbeek, A. M. Chumakov, A. D. Friedman, and H. P. Koeffler (1998)
J. Biol. Chem.
273, 14796-14804
| Abstract »
| Full Text »
| PDF »
- Effects of Age on the Posttranscriptional Regulation of CCAAT/Enhancer Binding Protein alpha and CCAAT/Enhancer Binding Protein beta Isoform Synthesis in Control and LPS-Treated Livers.
- C.-C. Hsieh, W. Xiong, Q. Xie, J. P. Rabek, S. G. Scott, M. R. An, P. D. Reisner, D. T. Kuninger, and J. Papaconstantinou (1998)
Mol. Biol. Cell
9, 1479-1494
| Abstract »
| Full Text »
- Overexpression of C/EBPbeta Represses Human Papillomavirus Type 18 Upstream Regulatory Region Activity in HeLa Cells by Interfering with the Binding of TATA-Binding Protein.
- T. Bauknecht and Y. Shi (1998)
J. Virol.
72, 2113-2124
| Abstract »
| Full Text »
| PDF »
- Pancreatic beta -Cell-specific Repression of Insulin Gene Transcription by CCAAT/Enhancer-binding Protein beta . INHIBITORY INTERACTIONS WITH BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR E47.
- M. Lu, J. Seufert, and J. F. Habener (1997)
J. Biol. Chem.
272, 28349-28359
| Abstract »
| Full Text »
| PDF »
- Cytoplasmic Localization of a Functionally Active Fanconi Anemia Group A-Green Fluorescent Protein Chimera in Human 293 Cells.
- F. A.E. Kruyt, Q. Waisfisz, L. M. Dijkmans, M. A.J.A. Hermsen, H. Youssoufian, F. Arwert, and H. Joenje (1997)
Blood
90, 3288-3295
| Abstract »
| Full Text »
| PDF »
- Transcription Factors, Normal Myeloid Development, and Leukemia.
- D. G. Tenen, R. Hromas, J. D. Licht, and D.-E. Zhang (1997)
Blood
90, 489-519
| Full Text »
| PDF »
- ATF-2 and C/EBPalpha Can Form a Heterodimeric DNA Binding Complex in Vitro. FUNCTIONAL IMPLICATIONS FOR TRANSCRIPTIONAL REGULATION.
- J. D. Shuman, J. Cheong, and J. E. Coligan (1997)
J. Biol. Chem.
272, 12793-12800
| Abstract »
| Full Text »
| PDF »
- Mouse RAD50 Has Limited Epitopic Homology to p53 and Is Expressed in the Adult Myocardium.
- K. K. Kim, A. I. Daud, S. C. Wong, L. Pajak, S.-C. Tsai, H. Wang, W. J. Henzel, and L. J. Field (1996)
J. Biol. Chem.
271, 29255-29264
| Abstract »
| Full Text »
| PDF »
- Molecular Cloning and Characterization of Two Isoforms of Saccharomyces cerevisiae Acyl-CoA:Sterol Acyltransferase.
- C. Yu, N. J. Kennedy, C. C.Y. Chang, and J. A. Rothblatt (1996)
J. Biol. Chem.
271, 24157-24163
| Abstract »
| Full Text »
| PDF »
- Regulation of CCAAT/Enhancer-binding Protein Family Members by Stimulation of Glutamate Receptors in Cultured Rat Cortical Astrocytes.
- S. Yano, K. Fukunaga, M. Takiguchi, Y. Ushio, M. Mori, and E. Miyamoto (1996)
J. Biol. Chem.
271, 23520-23527
| Abstract »
| Full Text »
| PDF »
- REVIEW {blacksquare} : Regulation of Gene Expression by Neural Signals.
- S. E. Hyman (1996)
Neuroscientist
2, 217-224
| Abstract »
| PDF »
- Physical and Functional Association between GADD153 and CCAAT/Enhancer-binding Protein beta during Cellular Stress.
- TimothyW. Fawcett, HelenB. Eastman, JenniferL. Martindale, and NikkiJ. Holbrook (1996)
J. Biol. Chem.
271, 14285-14289
| Abstract »
| Full Text »
| PDF »
- CCAAT/enhancer-binding protein alpha (C/EBP alpha) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein..
- N A Timchenko, M Wilde, M Nakanishi, J R Smith, and G J Darlington (1996)
Genes & Dev.
10, 804-815
| Abstract »
| PDF »
- Molecular and genetic characterization of GABP beta..
- F C de la Brousse, E H Birkenmeier, D S King, L B Rowe, and S L McKnight (1994)
Genes & Dev.
8, 1853-1865
| Abstract »
| PDF »
- Three levels of functional interaction determine the activity of CCAAT/enhancer binding protein-alpha on the serum albumin promoter..
- C Nerlov and E B Ziff (1994)
Genes & Dev.
8, 350-362
| Abstract »
| PDF »
- Genesis of an organ: molecular analysis of the pha-1 gene.
- M Granato, H Schnabel, and R Schnabel (1994)
Development
120, 3005-3017
| Abstract »
| PDF »
- Dimerization specificity of myogenic helix-loop-helix DNA-binding factors directed by nonconserved hydrophilic residues..
- M Shirakata, F K Friedman, Q Wei, and B M Paterson (1993)
Genes & Dev.
7, 2456-2470
| Abstract »
| PDF »
- HTLV-I Tax protein stimulation of DNA binding of bZIP proteins by enhancing dimerization.
- S Wagner and M. Green (1993)
Science
262, 395-399
| Abstract »
| PDF »
- Cooperative interactions between the Caenorhabditis elegans homeoproteins UNC-86 and MEC-3.
- D Xue, Y Tu, and M Chalfie (1993)
Science
261, 1324-1328
| Abstract »
| PDF »
- A bZIP protein, sisterless-a, collaborates with bHLH transcription factors early in Drosophila development to determine sex..
- J W Erickson and T W Cline (1993)
Genes & Dev.
7, 1688-1702
| Abstract »
| PDF »
- Dimerization specificity of the leucine zipper-containing bZIP motif on DNA binding: prediction and rational design..
- C R Vinson, T Hai, and S M Boyd (1993)
Genes & Dev.
7, 1047-1058
| Abstract »
| PDF »
- Altered specificity of DNA-binding proteins with transition metal dimerization domains.
- B Cuenoud and A Schepartz (1993)
Science
259, 510-513
| Abstract »
| PDF »
- Tissue-specific RNA splicing generates an ankyrin-like domain that affects the dimerization and DNA-binding properties of a bHLH protein..
- E S Klein, D M Simmons, L W Swanson, and M G Rosenfeld (1993)
Genes & Dev.
7, 55-71
| Abstract »
| PDF »
- Cell phenotype, binding affinity and promoter structure modulate transactivation by HNF1 and LAP.
- P. O. Angrand, J. P. Rousset, and M. C. Weiss (1992)
J. Cell Sci.
103, 1083-1092
| Abstract »
| PDF »
- Drosophila C/EBP: a tissue-specific DNA-binding protein required for embryonic development..
- P Rorth and D J Montell (1992)
Genes & Dev.
6, 2299-2311
| Abstract »
| PDF »
- Interaction of murine ets-1 with GGA-binding sites establishes the ETS domain as a new DNA-binding motif..
- J A Nye, J M Petersen, C V Gunther, M D Jonsen, and B J Graves (1992)
Genes & Dev.
6, 975-990
| Abstract »
| PDF »
- CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription..
- D Ron and J F Habener (1992)
Genes & Dev.
6, 439-453
| Abstract »
| PDF »
- A conserved regulatory unit implicated in tissue-specific gene expression in Drosophila and man..
- D Falb and T Maniatis (1992)
Genes & Dev.
6, 454-465
| Abstract »
| PDF »
- A Drosophila CREB/ATF transcriptional activator binds to both fat body- and liver-specific regulatory elements..
- T Abel, R Bhatt, and T Maniatis (1992)
Genes & Dev.
6, 466-480
| Abstract »
| PDF »
- Predicted structural similarities of the DNA binding domains of c-Myc and endonuclease Eco RI.
- T. Halazonetis and A. Kandil (1992)
Science
255, 464-466
| Abstract »
| PDF »
- DNA-binding properties of the HMG domain of the lymphoid-specific transcriptional regulator LEF-1..
- K Giese, A Amsterdam, and R Grosschedl (1991)
Genes & Dev.
5, 2567-2578
| Abstract »
| PDF »
- DNA bending by Fos and Jun: the flexible hinge model.
- T. Kerppola and T Curran (1991)
Science
254, 1210-1214
| Abstract »
| PDF »
- A dominant negative form of transcription activator mTFE3 created by differential splicing.
- C Roman, L Cohn, and K Calame (1991)
Science
254, 94-97
| Abstract »
| PDF »
- TEF, a transcription factor expressed specifically in the anterior pituitary during embryogenesis, defines a new class of leucine zipper proteins..
- D W Drolet, K M Scully, D M Simmons, M Wegner, K T Chu, L W Swanson, and M G Rosenfeld (1991)
Genes & Dev.
5, 1739-1753
| Abstract »
| PDF »
- Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells..
- Z Cao, R M Umek, and S L McKnight (1991)
Genes & Dev.
5, 1538-1552
| Abstract »
| PDF »
- A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro..
- S C Williams, C A Cantwell, and P F Johnson (1991)
Genes & Dev.
5, 1553-1567
| Abstract »
| PDF »
- Transcriptional regulation of a pair-rule stripe in Drosophila..
- S Small, R Kraut, T Hoey, R Warrior, and M Levine (1991)
Genes & Dev.
5, 827-839
| Abstract »
| PDF »
- Analysis of the DNA-binding and activation properties of the human transcription factor AP-2..
- T Williams and R Tjian (1991)
Genes & Dev.
5, 670-682
| Abstract »
| PDF »
- Characterization of a dimerization motif in AP-2 and its function in heterologous DNA-binding proteins.
- T Williams and R Tjian (1991)
Science
251, 1067-1071
| Abstract »
| PDF »
- An arginine to lysine substitution in the bZIP domain of an opaque-2 mutant in maize abolishes specific DNA binding..
- M J Aukerman, R J Schmidt, B Burr, and F A Burr (1991)
Genes & Dev.
5, 310-320
| Abstract »
| PDF »
- CCAAT-enhancer binding protein: a component of a differentiation switch.
- R. Umek, A. Friedman, and S. McKnight (1991)
Science
251, 288-292
| Abstract »
| PDF »
- Sequence requirements for coiled-coils: analysis with lambda repressor-GCN4 leucine zipper fusions.
- J. Hu, E. O'Shea, P. Kim, and R. Sauer (1990)
Science
250, 1400-1403
| Abstract »
| PDF »
- Sequence-specific binding of human Ets-1 to the T cell receptor alpha gene enhancer.
- I. Ho, N. Bhat, L. Gottschalk, T Lindsten, C. Thompson, T. Papas, and J. Leiden (1990)
Science
250, 814-818
| Abstract »
| PDF »
- The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer..
- P D Gregor, M Sawadogo, and R G Roeder (1990)
Genes & Dev.
4, 1730-1740
| Abstract »
| PDF »
- Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity..
- Y F Hu, B Luscher, A Admon, N Mermod, and R Tjian (1990)
Genes & Dev.
4, 1741-1752
| Abstract »
| PDF »
- The ETS-domain: a new DNA-binding motif that recognizes a purine-rich core DNA sequence..
- F D Karim, L D Urness, C S Thummel, M J Klemsz, S R McKercher, A Celada, C Van Beveren, R A Maki, C V Gunther, and J A Nye (1990)
Genes & Dev.
4, 1451-1453
| PDF »
- LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein..
- P Descombes, M Chojkier, S Lichtsteiner, E Falvey, and U Schibler (1990)
Genes & Dev.
4, 1541-1551
| Abstract »
| PDF »
- Sequence-specific DNA binding by a short peptide dimer.
- R. Talanian, C. McKnight, and P. Kim (1990)
Science
249, 769-771
| Abstract »
| PDF »
- Evidence of changes in protease sensitivity and subunit exchange rate on DNA binding by C/EBP.
- J. Shuman, C. Vinson, and S. McKnight (1990)
Science
249, 771-774
| Abstract »
| PDF »
- Ig/EBP-1: a ubiquitously expressed immunoglobulin enhancer binding protein that is similar to C/EBP and heterodimerizes with C/EBP..
- C Roman, J S Platero, J Shuman, and K Calame (1990)
Genes & Dev.
4, 1404-1415
| Abstract »
| PDF »
- Identification of two polypeptide segments of CCAAT/enhancer-binding protein required for transcriptional activation of the serum albumin gene..
- A D Friedman and S L McKnight (1990)
Genes & Dev.
4, 1416-1426
| Abstract »
| PDF »
- Structural motif of the GCN4 DNA binding domain characterized by affinity cleaving.
- M. Oakley and P. Dervan (1990)
Science
248, 847-850
| Abstract »
| PDF »
- Sequence-specific DNA binding of the proto-oncoprotein ets-1 defines a transcriptional activator sequence within the long terminal repeat of the Moloney murine sarcoma virus..
- C V Gunther, J A Nye, R S Bryner, and B J Graves (1990)
Genes & Dev.
4, 667-679
| Abstract »
| PDF »
|
|