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Science 24 March 1989:
Vol. 243. no. 4898, pp. 1611 - 1613
DOI: 10.1126/science.2467381
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Articles

Science, Vol 243, Issue 4898, 1611-1613
Copyright © 1989 by American Association for the Advancement of Science

articles

Indole-2-carboxylic acid: a competitive antagonist of potentiation by glycine at the NMDA receptor

JE Huettner

Department of Neurobiology, Harvard Medical School, Boston, MA 02115.

The N-methyl-D-aspartate (NMDA) class of excitatory amino acid receptors regulates the strength and stability of excitatory synapses and appears to play a major role in excitotoxic neuronal death associated with stroke and epilepsy. The conductance increase gated by NMDA is potentiated by the amino acid glycine, which acts at an allosteric site tightly coupled to the NMDA receptor. Indole-2-carboxylic acid (I2CA) specifically and competitively inhibits the potentiation by glycine of NMDA-gated current. In solutions containing low levels of glycine, I2CA completely blocks the response to NMDA, suggesting that NMDA alone is not sufficient for channel activation. I2CA will be useful for defining the interaction of glycine with NMDA receptors and for determining the in vivo role of glycine in excitotoxicity and synapse stabilization.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Glutamate But Not Glycine Agonist Affinity for NMDA Receptors Is Influenced by Small Cations.
R. Nahum-Levy, E. Tam, S. Shavit, and M. Benveniste (2002)
J. Neurosci. 22, 2550-2560
   Abstract »    Full Text »    PDF »
Effects of (+)-HA-966, CGS-19755, Phencyclidine, and Dizocilpine on Repeated Acquisition of Response Chains in Pigeons: Systemic Manipulation of Central Glycine Sites.
C. M. Campbell, E. R. Butelman, and J. H. Woods (1999)
J. Pharmacol. Exp. Ther. 289, 521-527
   Abstract »    Full Text »
Glycine and N-Methyl-D-Aspartate Receptors: Physiological Significance and Possible Therapeutic Applications.
W. Danysz and C. G. Parsons (1998)
Pharmacol. Rev. 50, 597-664
   Abstract »    Full Text »    PDF »
Chronic Administration of a Glycine Partial Agonist Alters the Expression of N-Methyl-D-aspartate Receptor Subunit mRNAs.
S. Bovetto, P.-A. Boyer, P. Skolnick, and L. H. Fossom (1997)
J. Pharmacol. Exp. Ther. 283, 1503-1508
   Abstract »    Full Text »
Familial and developmental abnormalities of frontal lobe function and neurochemistry in schizophrenia.
J.F.W. Deakin, M.D.C. Simpson, P. Slater, and J.S.E. Hellewell (1997)
J Psychopharmacol 11, 133-142
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)