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Science 24 March 1989:
Vol. 243. no. 4898, pp. 1603 - 1606
DOI: 10.1126/science.2538924
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Articles

Science, Vol 243, Issue 4898, 1603-1606
Copyright © 1989 by American Association for the Advancement of Science

articles

Activity-dependent enhancement of presynaptic inhibition in Aplysia sensory neurons

SA Small, ER Kandel, and RD Hawkins

Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, New York, NY 10032.

Tail shock produces transient presynaptic inhibition and longer lasting presynaptic facilitation of the siphon sensory neurons in Aplysia. The facilitation undergoes activity-dependent enhancement that is thought to contribute to classical conditioning of the gill- and siphon-withdrawal reflex. Inhibition of the sensory neurons has now also been shown to undergo activity-dependent enhancement when action potential activity in the sensory neurons is paired with inhibitory transmitter. This effect appears to involve an amplification of the same cellular mechanisms that are involved in normal presynaptic inhibition. These results suggest that activity-dependent enhancement may be a general type of associative cellular mechanism.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Neural Circuit of Tail-Elicited Siphon Withdrawal in Aplysia. II. Role of Gated Inhibition in Differential Lateralization of Sensitization and Dishabituation.
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Disruption of a Neuropeptide Gene, flp-1, Causes Multiple Behavioral Defects in Caenorhabditis elegans.
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