Science 24 March 1989: Vol. 243. no. 4898, pp. 1576 - 1583 DOI: 10.1126/science.2538923

Prev | Table of Contents | Next

Articles

DUBs at a glance.

K. D. Wilkinson (2009)
J. Cell Sci. 122, 2325-2329
 |  Full Text »  |  PDF »

Ubiquitylation on Canonical and Non-canonical Sites Targets the Transcription Factor Neurogenin for Ubiquitin-mediated Proteolysis.

J. M. D. Vosper, G. S. McDowell, C. J. Hindley, C. S. Fiore-Heriche, R. Kucerova, I. Horan, and A. Philpott (2009)
J. Biol. Chem. 284, 15458-15468
 |  Abstract »  |  Full Text »  |  PDF »

The malin-laforin complex suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system.

P. Garyali, P. Siwach, P. K. Singh, R. Puri, S. Mittal, S. Sengupta, R. Parihar, and S. Ganesh (2009)
Hum. Mol. Genet. 18, 688-700
 |  Abstract »  |  Full Text »  |  PDF »

Ubiquitin-Independent Degradation of Hepatitis C Virus F Protein.

K. Yuksek, W.-l. Chen, D. Chien, and J.-h. J. Ou (2009)
J. Virol. 83, 612-621
 |  Abstract »  |  Full Text »  |  PDF »

Targeting Ubiquitin and Ubiquitin-like Modifier Pathways for Cancer Therapy.

K. M. Sakamoto (2009)
ASCO Educational Book 2009, 171-175
 |  Abstract »  |  Full Text »  |  PDF »

Discovery of Cellular Regulation by Protein Degradation.

A. Varshavsky (2008)
J. Biol. Chem. 283, 34469-34489
 |  Full Text »  |  PDF »

Recognition of Polyubiquitin Isoforms by the Multiple Ubiquitin Binding Modules of Isopeptidase T.

F. E. Reyes-Turcu, J. R. Shanks, D. Komander, and K. D. Wilkinson (2008)
J. Biol. Chem. 283, 19581-19592
 |  Abstract »  |  Full Text »  |  PDF »

Cue1p Is an Activator of Ubc7p E2 Activity in Vitro and in Vivo.

O. A. Bazirgan and R. Y. Hampton (2008)
J. Biol. Chem. 283, 12797-12810
 |  Abstract »  |  Full Text »  |  PDF »

Alg13p, the Catalytic Subunit of the Endoplasmic Reticulum UDP-GlcNAc Glycosyltransferase, Is a Target for Proteasomal Degradation.

N. Averbeck, X.-D. Gao, S.-I. Nishimura, and N. Dean (2008)
Mol. Biol. Cell 19, 2169-2178
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation of Activation Function-1 Regulates Proteasome-Dependent Nuclear Mobility and E6-Associated Protein Ubiquitin Ligase Recruitment to the Estrogen Receptor {beta}.

N. Picard, C. Charbonneau, M. Sanchez, A. Licznar, M. Busson, G. Lazennec, and A. Tremblay (2008)
Mol. Endocrinol. 22, 317-330
 |  Abstract »  |  Full Text »  |  PDF »

In Vivo Identification of Human Small Ubiquitin-like Modifier Polymerization Sites by High Accuracy Mass Spectrometry and an in Vitro to in Vivo Strategy.

I. Matic, M. van Hagen, J. Schimmel, B. Macek, S. C. Ogg, M. H. Tatham, R. T. Hay, A. I. Lamond, M. Mann, and A. C. O. Vertegaal (2008)
Mol. Cell. Proteomics 7, 132-144
 |  Abstract »  |  Full Text »  |  PDF »

Direct Catalysis of Lysine 48-linked Polyubiquitin Chains by the Ubiquitin-activating Enzyme.

J. T. Huzil, R. Pannu, C. Ptak, G. Garen, and M. J. Ellison (2007)
J. Biol. Chem. 282, 37454-37460
 |  Abstract »  |  Full Text »  |  PDF »

The Human T-Cell Leukemia Virus Type 1 Tax Oncoprotein Requires the Ubiquitin-Conjugating Enzyme Ubc13 for NF-{kappa}B Activation.

N. Shembade, N. S. Harhaj, M. Yamamoto, S. Akira, and E. W. Harhaj (2007)
J. Virol. 81, 13735-13742
 |  Abstract »  |  Full Text »  |  PDF »

Intracellular Trafficking and Maturation of Herpes Simplex Virus Type 1 gB and Virus Egress Require Functional Biogenesis of Multivesicular Bodies.

A. Calistri, P. Sette, C. Salata, E. Cancellotti, C. Forghieri, A. Comin, H. Gottlinger, G. Campadelli-Fiume, G. Palu, and C. Parolin (2007)
J. Virol. 81, 11468-11478
 |  Abstract »  |  Full Text »  |  PDF »

Kinase-active Interleukin-1 Receptor-associated Kinases Promote Polyubiquitination and Degradation of the Pellino Family: DIRECT EVIDENCE FOR PELLINO PROTEINS BEING UBIQUITIN-PROTEIN ISOPEPTIDE LIGASES.

M. P. Butler, J. A. Hanly, and P. N. Moynagh (2007)
J. Biol. Chem. 282, 29729-29737
 |  Abstract »  |  Full Text »  |  PDF »

Werner Helicase-interacting Protein 1 Binds Polyubiquitin via Its Zinc Finger Domain.

R. A. Bish and M. P. Myers (2007)
J. Biol. Chem. 282, 23184-23193
 |  Abstract »  |  Full Text »  |  PDF »

Ubiquitination is involved in glucose-mediated downregulation of GIP receptors in islets.

J. Zhou, M. F. A. Livak, M. Bernier, D. C. Muller, O. D. Carlson, D. Elahi, S. Maudsley, and J. M. Egan (2007)
Am J Physiol Endocrinol Metab 293, E538-E547
 |  Abstract »  |  Full Text »  |  PDF »

Certain Pairs of Ubiquitin-conjugating Enzymes (E2s) and Ubiquitin-Protein Ligases (E3s) Synthesize Nondegradable Forked Ubiquitin Chains Containing All Possible Isopeptide Linkages.

H. T. Kim, K. P. Kim, F. Lledias, A. F. Kisselev, K. M. Scaglione, D. Skowyra, S. P. Gygi, and A. L. Goldberg (2007)
J. Biol. Chem. 282, 17375-17386
 |  Abstract »  |  Full Text »  |  PDF »

Possible Function of Caudal Nuclear Pocket: Degradation of Nucleoproteins by Ubiquitin-Proteasome System in Rat Spermatids and Human Sperm.

C. M. Haraguchi, T. Mabuchi, S. Hirata, T. Shoda, T. Tokumoto, K. Hoshi, and S. Yokota (2007)
J. Histochem. Cytochem. 55, 585-595
 |  Abstract »  |  Full Text »  |  PDF »

Ubiquitin, Hormones and Biotic Stress in Plants.

K. Dreher and J. Callis (2007)
Ann. Bot. 99, 787-822
 |  Abstract »  |  Full Text »  |  PDF »

Ubiquitination of the peroxisomal import receptor Pex5p is required for its recycling.

H. W. Platta, F. E. Magraoui, D. Schlee, S. Grunau, W. Girzalsky, and R. Erdmann (2007)
J. Cell Biol. 177, 197-204
 |  Abstract »  |  Full Text »  |  PDF »

Ubiquitin-conjugating enzyme Ubc13 is a critical component of TNF receptor-associated factor (TRAF)-mediated inflammatory responses.

T. Fukushima, S.-i. Matsuzawa, C. L. Kress, J. M. Bruey, M. Krajewska, S. Lefebvre, J. M. Zapata, Z. Ronai, and J. C. Reed (2007)
PNAS 104, 6371-6376
 |  Abstract »  |  Full Text »  |  PDF »

TBP-interacting Protein 120B (TIP120B)/Cullin-associated and Neddylation-dissociated 2 (CAND2) Inhibits SCF-dependent Ubiquitination of Myogenin and Accelerates Myogenic Differentiation.

S. Shiraishi, C. Zhou, T. Aoki, N. Sato, T. Chiba, K. Tanaka, S. Yoshida, Y. Nabeshima, Y.-i. Nabeshima, and T.-a. Tamura (2007)
J. Biol. Chem. 282, 9017-9028
 |  Abstract »  |  Full Text »  |  PDF »

A Histidine-rich Cluster Mediates the Ubiquitination and Degradation of the Human Zinc Transporter, hZIP4, and Protects against Zinc Cytotoxicity.

X. Mao, B.-E. Kim, F. Wang, D. J. Eide, and M. J. Petris (2007)
J. Biol. Chem. 282, 6992-7000
 |  Abstract »  |  Full Text »  |  PDF »

BRCA1 Ubiquitinates RPB8 in Response to DNA Damage.

W. Wu, H. Nishikawa, R. Hayami, K. Sato, A. Honda, S. Aratani, T. Nakajima, M. Fukuda, and T. Ohta (2007)
Cancer Res. 67, 951-958
 |  Abstract »  |  Full Text »  |  PDF »

The Deubiquitinating Enzyme Ubp2 Modulates Rsp5-dependent Lys63-linked Polyubiquitin Conjugates in Saccharomyces cerevisiae.

Y. Kee, W. Munoz, N. Lyon, and J. M. Huibregtse (2006)
J. Biol. Chem. 281, 36724-36731
 |  Abstract »  |  Full Text »  |  PDF »

Slug stability is dynamically regulated during neural crest development by the F-box protein Ppa.

A. E. Vernon and C. LaBonne (2006)
Development 133, 3359-3370
 |  Abstract »  |  Full Text »  |  PDF »

New insights into the regulation of TLR signaling.

S. M. Miggin and L. A. J. O'Neill (2006)
J. Leukoc. Biol. 80, 220-226
 |  Abstract »  |  Full Text »  |  PDF »

Intracellular Protein Degradation: From a Vague Idea Thru the Lysosome and the Ubiquitin-Proteasome System and onto Human Diseases and Drug Targeting..

A. Ciechanover (2006)
Experimental Biology and Medicine 231, 1197-1211
 |  Abstract »  |  Full Text »  |  PDF »

The Ubiquitin Isopeptidase UBPY Regulates Endosomal Ubiquitin Dynamics and Is Essential for Receptor Down-regulation.

P. E. Row, I. A. Prior, J. McCullough, M. J. Clague, and S. Urbe (2006)
J. Biol. Chem. 281, 12618-12624
 |  Abstract »  |  Full Text »  |  PDF »

SUMO-1 Controls the Protein Stability and the Biological Function of Phosducin.

C. Klenk, J. Humrich, U. Quitterer, and M. J. Lohse (2006)
J. Biol. Chem. 281, 8357-8364
 |  Abstract »  |  Full Text »  |  PDF »

Assembly of a Polymeric Chain of SUMO1 on Human Topoisomerase I in Vitro.

M. Yang, C.-T. Hsu, C.-Y. Ting, L. F. Liu, and J. Hwang (2006)
J. Biol. Chem. 281, 8264-8274
 |  Abstract »  |  Full Text »  |  PDF »

Interferon-Inducible Protein IFIX{alpha}1 Functions as a Negative Regulator of HDM2..

Y. Ding, J.-F. Lee, H. Lu, M.-H. Lee, and D.-H. Yan (2006)
Mol. Cell. Biol. 26, 1979-1996
 |  Abstract »  |  Full Text »  |  PDF »

Degrade to create: developmental requirements for ubiquitin-mediated proteolysis during early C. elegans embryogenesis.

B. Bowerman and T. Kurz (2006)
Development 133, 773-784
 |  Abstract »  |  Full Text »  |  PDF »

Intracellular Protein Degradation: From a Vague Idea thru the Lysosome and the Ubiquitin-Proteasome System and onto Human Diseases and Drug Targeting.

A. Ciechanover (2006)
Hematology 2006, 1-12
 |  Abstract »  |  Full Text »  |  PDF »

New insights into the post-translational modification of Toll-like receptor signaling molecules.

A. Dunne and L. O'Neill (2005)
Innate Immunity 11, 325-332
 |  Abstract »  |  PDF »

The discovery of ubiquitin-dependent proteolysis.

K. D. Wilkinson (2005)
PNAS 102, 15280-15282
 |  Abstract »  |  Full Text »  |  PDF »

Dissecting the mechanical unfolding of ubiquitin.

A. Irback, S. Mitternacht, and S. Mohanty (2005)
PNAS 102, 13427-13432
 |  Abstract »  |  Full Text »  |  PDF »

Distinct regulation of Ubc13 functions by the two ubiquitin-conjugating enzyme variants Mms2 and Uev1A.

P. L. Andersen, H. Zhou, L. Pastushok, T. Moraes, S. McKenna, B. Ziola, M. J. Ellison, V. M. Dixit, and W. Xiao (2005)
J. Cell Biol. 170, 745-755
 |  Abstract »  |  Full Text »  |  PDF »

A Family of Mammalian E3 Ubiquitin Ligases That Contain the UBR Box Motif and Recognize N-Degrons.

T. Tasaki, L. C. F. Mulder, A. Iwamatsu, M. J. Lee, I. V. Davydov, A. Varshavsky, M. Muesing, and Y. T. Kwon (2005)
Mol. Cell. Biol. 25, 7120-7136
 |  Abstract »  |  Full Text »  |  PDF »

The Ubiquitin-Proteasome Pathway and Its Role in Cancer.

A. Mani and E. P. Gelmann (2005)
J. Clin. Oncol. 23, 4776-4789
 |  Abstract »  |  Full Text »  |  PDF »

Analysis of Polyubiquitin Conjugates Reveals That the Rpn10 Substrate Receptor Contributes to the Turnover of Multiple Proteasome Targets.

T. Mayor, J. R. Lipford, J. Graumann, G. T. Smith, and R. J. Deshaies (2005)
Mol. Cell. Proteomics 4, 741-751
 |  Abstract »  |  Full Text »  |  PDF »

Lys6-modified Ubiquitin Inhibits Ubiquitin-dependent Protein Degradation.

F. Shang, G. Deng, Q. Liu, W. Guo, A. L. Haas, B. Crosas, D. Finley, and A. Taylor (2005)
J. Biol. Chem. 280, 20365-20374
 |  Abstract »  |  Full Text »  |  PDF »

Eap45 in Mammalian ESCRT-II Binds Ubiquitin via a Phosphoinositide-interacting GLUE Domain.

T. Slagsvold, R. Aasland, S. Hirano, K. G. Bache, C. Raiborg, D. Trambaiolo, S. Wakatsuki, and H. Stenmark (2005)
J. Biol. Chem. 280, 19600-19606
 |  Abstract »  |  Full Text »  |  PDF »

Ubiquitin Binding Site of the Ubiquitin E2 Variant (UEV) Protein Mms2 Is Required for DNA Damage Tolerance in the Yeast RAD6 Pathway.

C. Tsui, A. Raguraj, and C. M. Pickart (2005)
J. Biol. Chem. 280, 19829-19835
 |  Abstract »  |  Full Text »  |  PDF »

{alpha}-Synuclein and Parkin Contribute to the Assembly of Ubiquitin Lysine 63-linked Multiubiquitin Chains.

E. W. Doss-Pepe, L. Chen, and K. Madura (2005)
J. Biol. Chem. 280, 16619-16624
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of E3Histone, a Novel Testis Ubiquitin Protein Ligase Which Ubiquitinates Histones.

Z. Liu, R. Oughtred, and S. S. Wing (2005)
Mol. Cell. Biol. 25, 2819-2831
 |  Abstract »  |  Full Text »  |  PDF »

Parkin Mediates Nonclassical, Proteasomal-Independent Ubiquitination of Synphilin-1: Implications for Lewy Body Formation.

K. L. Lim, K. C. M. Chew, J. M. M. Tan, C. Wang, K. K. K. Chung, Y. Zhang, Y. Tanaka, W. Smith, S. Engelender, C. A. Ross, et al. (2005)
J. Neurosci. 25, 2002-2009
 |  Abstract »  |  Full Text »  |  PDF »

Novel Interaction between Apc5p and Rsp5p in an Intracellular Signaling Pathway in Saccharomyces cerevisiae.

T. G. Arnason, M. G. Pisclevich, M. D. Dash, G. F. Davies, and T. A. A. Harkness (2005)
Eukaryot. Cell 4, 134-146
 |  Abstract »  |  Full Text »  |  PDF »

Functional Regulation of FEZ1 by the U-box-type Ubiquitin Ligase E4B Contributes to Neuritogenesis.

F. Okumura, S. Hatakeyama, M. Matsumoto, T. Kamura, and K. I. Nakayama (2004)
J. Biol. Chem. 279, 53533-53543
 |  Abstract »  |  Full Text »  |  PDF »

Ubiquitination and Down-regulation of Gap Junction Protein Connexin-43 in Response to 12-O-Tetradecanoylphorbol 13-Acetate Treatment.

E. Leithe and E. Rivedal (2004)
J. Biol. Chem. 279, 50089-50096
 |  Abstract »  |  Full Text »  |  PDF »

In situ dynamically monitoring the proteolytic function of the ubiquitin-proteasome system in cultured cardiac myocytes.

X. Dong, J. Liu, H. Zheng, J. W. Glasford, W. Huang, Q. H. Chen, N. R. Harden, F. Li, A. M. Gerdes, and X. Wang (2004)
Am J Physiol Heart Circ Physiol 287, H1417-H1425
 |  Abstract »  |  Full Text »  |  PDF »

Structural Insights into Endosomal Sorting Complex Required for Transport (ESCRT-I) Recognition of Ubiquitinated Proteins.

H. Teo, D. B. Veprintsev, and R. L. Williams (2004)
J. Biol. Chem. 279, 28689-28696
 |  Abstract »  |  Full Text »  |  PDF »

Phase I Study of Bortezomib in Refractory or Relapsed Acute Leukemias.

J. Cortes, D. Thomas, C. Koller, F. Giles, E. Estey, S. Faderl, G. Garcia-Manero, D. McConkey, G. Patel, R. Guerciolini, et al. (2004)
Clin. Cancer Res. 10, 3371-3376
 |  Abstract »  |  Full Text »  |  PDF »

Specificity of the Interaction between Ubiquitin-associated Domains and Ubiquitin.

T. D. Mueller, M. Kamionka, and J. Feigon (2004)
J. Biol. Chem. 279, 11926-11936
 |  Abstract »  |  Full Text »  |  PDF »

Solution Conformation of Lys63-linked Di-ubiquitin Chain Provides Clues to Functional Diversity of Polyubiquitin Signaling.

R. Varadan, M. Assfalg, A. Haririnia, S. Raasi, C. Pickart, and D. Fushman (2004)
J. Biol. Chem. 279, 7055-7063
 |  Abstract »  |  Full Text »  |  PDF »

Mass Spectrometric and Mutational Analyses Reveal Lys-6-linked Polyubiquitin Chains Catalyzed by BRCA1-BARD1 Ubiquitin Ligase.

H. Nishikawa, S. Ooka, K. Sato, K. Arima, J. Okamoto, R. E. Klevit, M. Fukuda, and T. Ohta (2004)
J. Biol. Chem. 279, 3916-3924
 |  Abstract »  |  Full Text »  |  PDF »

Human HRD1 Is an E3 Ubiquitin Ligase Involved in Degradation of Proteins from the Endoplasmic Reticulum.

M. Kikkert, R. Doolman, M. Dai, R. Avner, G. Hassink, S. van Voorden, S. Thanedar, J. Roitelman, V. Chau, and E. Wiertz (2004)
J. Biol. Chem. 279, 3525-3534
 |  Abstract »  |  Full Text »  |  PDF »

TopNet: a tool for comparing biological sub-networks, correlating protein properties with topological statistics.

H. Yu, X. Zhu, D. Greenbaum, J. Karro, and M. Gerstein (2004)
Nucleic Acids Res. 32, 328-337
 |  Abstract »  |  Full Text »  |  PDF »

Smac3, a Novel Smac/DIABLO Splicing Variant, Attenuates the Stability and Apoptosis-inhibiting Activity of X-linked Inhibitor of Apoptosis Protein.

J. Fu, Y. Jin, and L. J. Arend (2003)
J. Biol. Chem. 278, 52660-52672
 |  Abstract »  |  Full Text »  |  PDF »

Ataxin-3 Interactions with Rad23 and Valosin-Containing Protein and Its Associations with Ubiquitin Chains and the Proteasome Are Consistent with a Role in Ubiquitin-Mediated Proteolysis.

E. W. Doss-Pepe, E. S. Stenroos, W. G. Johnson, and K. Madura (2003)
Mol. Cell. Biol. 23, 6469-6483
 |  Abstract »  |  Full Text »  |  PDF »

The BRCA1/BARD1 Heterodimer Assembles Polyubiquitin Chains through an Unconventional Linkage Involving Lysine Residue K6 of Ubiquitin.

F. Wu-Baer, K. Lagrazon, W. Yuan, and R. Baer (2003)
J. Biol. Chem. 278, 34743-34746
 |  Abstract »  |  Full Text »  |  PDF »

Polyubiquitin Serves as a Recognition Signal, Rather than a Ratcheting Molecule, during Retrotranslocation of Proteins across the Endoplasmic Reticulum Membrane.

D. Flierman, Y. Ye, M. Dai, V. Chau, and T. A. Rapoport (2003)
J. Biol. Chem. 278, 34774-34782
 |  Abstract »  |  Full Text »  |  PDF »

Intracellular clusterin causes juxtanuclear aggregate formation and mitochondrial alteration.

L. Debure, J.-L. Vayssiere, V. Rincheval, F. Loison, Y. Le Drean, and D. Michel (2003)
J. Cell Sci. 116, 3109-3121
 |  Abstract »  |  Full Text »  |  PDF »

Deubiquitinating Enzymes as Cellular Regulators.

J. H. Kim, K. C. Park, S. S. Chung, O. Bang, and C. H. Chung (2003)
J. Biochem. 134, 9-18
 |  Abstract »  |  Full Text »  |  PDF »

Proteolytic Targeting of Transcriptional Regulator TIP120B by a HECT Domain E3 Ligase.

J. You, M. Wang, T. Aoki, T.-a. Tamura, and C. M. Pickart (2003)
J. Biol. Chem. 278, 23369-23375
 |  Abstract »  |  Full Text »  |  PDF »

gamma 2 subunit of G protein heterotrimer is an N-end rule ubiquitylation substrate.

M. H. Hamilton, L. A. Cook, T. R. McRackan, K. L. Schey, and J. D. Hildebrandt (2003)
PNAS 100, 5081-5086
 |  Abstract »  |  Full Text »  |  PDF »

An NMR-based Model of the Ubiquitin-bound Human Ubiquitin Conjugation Complex Mms2{middle dot}Ubc13. THE STRUCTURAL BASIS FOR LYSINE 63 CHAIN CATALYSIS.

S. McKenna, T. Moraes, L. Pastushok, C. Ptak, W. Xiao, L. Spyracopoulos, and M. J. Ellison (2003)
J. Biol. Chem. 278, 13151-13158
 |  Abstract »  |  Full Text »  |  PDF »

Supramolecular Complex Formation between Rad6 and Proteins of the p53 Pathway during DNA Damage-Induced Response.

A. Lyakhovich and M. P. V. Shekhar (2003)
Mol. Cell. Biol. 23, 2463-2475
 |  Abstract »  |  Full Text »  |  PDF »

Proteasome-dependent, ubiquitin-independent degradation of the Rb family of tumor suppressors by the human cytomegalovirus pp71 protein.

R. F. Kalejta and T. Shenk (2003)
PNAS 100, 3263-3268
 |  Abstract »  |  Full Text »  |  PDF »

Rad23 Ubiquitin-associated Domains (UBA) Inhibit 26 S Proteasome-catalyzed Proteolysis by Sequestering Lysine 48-linked Polyubiquitin Chains.

S. Raasi and C. M. Pickart (2003)
J. Biol. Chem. 278, 8951-8959
 |  Abstract »  |  Full Text »  |  PDF »

Protein Interactions within the N-end Rule Ubiquitin Ligation Pathway.

T. J. Siepmann, R. N. Bohnsack, Z. Tokgoz, O. V. Baboshina, and A. L. Haas (2003)
J. Biol. Chem. 278, 9448-9457
 |  Abstract »  |  Full Text »  |  PDF »

Protein-Protein Interactions within an E2-RING Finger Complex. IMPLICATIONS FOR UBIQUITIN-DEPENDENT DNA DAMAGE REPAIR.

H. D. Ulrich (2003)
J. Biol. Chem. 278, 7051-7058
 |  Abstract »  |  Full Text »  |  PDF »

MdmX Is a RING Finger Ubiquitin Ligase Capable of Synergistically Enhancing Mdm2 Ubiquitination.

J. C. Badciong and A. L. Haas (2002)
J. Biol. Chem. 277, 49668-49675
 |  Abstract »  |  Full Text »  |  PDF »

Mcm3 Is Polyubiquitinated during Mitosis before Establishment of the Pre-replication Complex.

I. H. Cheng, L. A. Roberts, and B. K. Tye (2002)
J. Biol. Chem. 277, 41706-41714
 |  Abstract »  |  Full Text »  |  PDF »

Fusion Proteins with COOH-terminal Ubiquitin Are Stable and Maintain Dual Functionality in Vivo.

S.-B. Qian, D. E. Ott, U. Schubert, J. R. Bennink, and J. W. Yewdell (2002)
J. Biol. Chem. 277, 38818-38826
 |  Abstract »  |  Full Text »  |  PDF »

A Rhodopsin Mutant Linked to Autosomal Dominant Retinitis Pigmentosa Is Prone to Aggregate and Interacts with the Ubiquitin Proteasome System.

M. E. Illing, R. S. Rajan, N. F. Bence, and R. R. Kopito (2002)
J. Biol. Chem. 277, 34150-34160
 |  Abstract »  |  Full Text »  |  PDF »

Autoubiquitination of the BRCA1{middle dot}BARD1 RING Ubiquitin Ligase.

A. Chen, F. E. Kleiman, J. L. Manley, T. Ouchi, and Z.-Q. Pan (2002)
J. Biol. Chem. 277, 22085-22092
 |  Abstract »  |  Full Text »  |  PDF »

Late Assembly Domain Function Can Exhibit Context Dependence and Involves Ubiquitin Residues Implicated in Endocytosis.

B. Strack, A. Calistri, and H. G. Gottlinger (2002)
J. Virol. 76, 5472-5479
 |  Abstract »  |  Full Text »  |  PDF »

Sla1p serves as the targeting signal recognition factor for NPFX(1,2)D-mediated endocytosis.

J. P. Howard, J. L. Hutton, J. M. Olson, and G. S. Payne (2002)
J. Cell Biol. 157, 315-326
 |  Abstract »  |  Full Text »  |  PDF »

The Epithelial Na+ Channel: Cell Surface Insertion and Retrieval in Na+ Homeostasis and Hypertension.

P. M. Snyder (2002)
Endocr. Rev. 23, 258-275
 |  Abstract »  |  Full Text »  |  PDF »

Requirement of RAD5 and MMS2 for Postreplication Repair of UV-Damaged DNA in Saccharomyces cerevisiae.

C. A. Torres-Ramos, S. Prakash, and L. Prakash (2002)
Mol. Cell. Biol. 22, 2419-2426
 |  Abstract »  |  Full Text »  |  PDF »

Two Distinct Proteolytic Systems Responsible for Glucose-induced Degradation of Fructose-1,6-bisphosphatase and the Gal2p Transporter in the Yeast Saccharomyces cerevisiae Share the Same Protein Components of the Glucose Signaling Pathway.

J. Horak, J. Regelmann, and D. H. Wolf (2002)
J. Biol. Chem. 277, 8248-8254
 |  Abstract »  |  Full Text »  |  PDF »

Degradation or Maintenance: Actions of the Ubiquitin System on Eukaryotic Chromatin.

H. D. Ulrich (2002)
Eukaryot. Cell 1, 1-10
 |  Full Text »  |  PDF »

A Homologue of CROC-1 in a Ciliated Protist (Sterkiella histriomuscorum) Testifies to the Ancient Origin of the Ubiquitin-conjugating Enzyme Variant Family.

E. Villalobo, L. Morin, C. Moch, R. Lescasse, M. Hanna, W. Xiao, and A. Baroin-Tourancheau (2002)
Mol. Biol. Evol. 19, 39-48
 |  Abstract »  |  Full Text »  |  PDF »

Construction and Analysis of Mouse Strains Lacking the Ubiquitin Ligase UBR1 (E3alpha ) of the N-End Rule Pathway.

Y. T. Kwon, Z. Xia, I. V. Davydov, S. H. Lecker, and A. Varshavsky (2001)
Mol. Cell. Biol. 21, 8007-8021
 |  Abstract »  |  Full Text »  |  PDF »

Kinetic Analysis of the Conjugation of Ubiquitin to Picornavirus 3C Proteases Catalyzed by the Mammalian Ubiquitin-protein Ligase E3alpha.

T. G. Lawson, M. E. Sweep, P. E. Schlax, R. N. Bohnsack, and A. L. Haas (2001)
J. Biol. Chem. 276, 39629-39637
 |  Abstract »  |  Full Text »  |  PDF »

N-end Rule Specificity within the Ubiquitin/Proteasome Pathway Is Not an Affinity Effect.

O. V. Baboshina, R. Crinelli, T. J. Siepmann, and A. L. Haas (2001)
J. Biol. Chem. 276, 39428-39437
 |  Abstract »  |  Full Text »  |  PDF »

Rapid Degradation of Auxin/Indoleacetic Acid Proteins Requires Conserved Amino Acids of Domain II and Is Proteasome Dependent.

J. A. Ramos, N. Zenser, O. Leyser, and J. Callis (2001)
PLANT CELL 13, 2349-2360
 |  Abstract »  |  Full Text »  |  PDF »

In Vivo Action of the HRD Ubiquitin Ligase Complex: Mechanisms of Endoplasmic Reticulum Quality Control and Sterol Regulation.

R. G. Gardner, A. G. Shearer, and R. Y. Hampton (2001)
Mol. Cell. Biol. 21, 4276-4291
 |  Abstract »  |  Full Text »  |  PDF »

RPN4 is a ligand, substrate, and transcriptional regulator of the 26S proteasome: A negative feedback circuit.

Y. Xie and A. Varshavsky (2001)
PNAS 98, 3056-3061
 |  Abstract »  |  Full Text »  |  PDF »

Alteration of the stability of Bag-1 protein in the control of olfactory neuronal apoptosis.

T Sourisseau, C Desbois, L Debure, D. Bowtell, A. Cato, J Schneikert, E Moyse, and D Michel (2001)
J. Cell Sci. 114, 1409-1416
 |  Abstract »  |  PDF »

Detecting and Measuring Cotranslational Protein Degradation in.

G. Turner and Varshavsky (2000)
Science 289, 2117-2120
 |  Abstract »  |  Full Text »

Altered Activity, Social Behavior, and Spatial Memory in Mice Lacking the NTAN1p Amidase and the Asparagine Branch of the N-End Rule Pathway.

Y. T. Kwon, S. A. Balogh, I. V. Davydov, A. S. Kashina, J. K. Yoon, Y. Xie, A. Gaur, L. Hyde, V. H. Denenberg, and A. Varshavsky (2000)
Mol. Cell. Biol. 20, 4135-4148
 |  Abstract »  |  Full Text »

c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi.

M. Wu, T. J. Hemesath, C. M. Takemoto, M. A. Horstmann, A. G. Wells, E. R. Price, D. Z. Fisher, and D. E. Fisher (2000)
Genes & Dev. 14, 301-312
 |  Abstract »  |  Full Text »

The Role of Multiubiquitination in Dislocation and Degradation of the alpha Subunit of the T Cell Antigen Receptor.

H. Yu and R. R. Kopito (1999)
J. Biol. Chem. 274, 36852-36858
 |  Abstract »  |  Full Text »  |  PDF »

Degradation of the Basic Helix-Loop-Helix/Per-ARNT-Sim Homology Domain Dioxin Receptor Via the Ubiquitin/Proteasome Pathway.

B. J. Roberts and M. L. Whitelaw (1999)
J. Biol. Chem. 274, 36351-36356
 |  Abstract »  |  Full Text »  |  PDF »

To Advertise   |   Find Products