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ArticlesCopyright © 1989 by American Association for the Advancement of Science
Reduction of intestinal carcinogen absorption by carcinogen-specific secretory immunity
University of Michigan, Pathology Department, Ann Arbor, MI 48109.
A secretory immune response to the carcinogen 2-acetylaminofluorene (AAF) was elicited in rabbits by directly immunizing the small intestine with an AAF-cholera toxin conjugate. High-titer, high-affinity secretory immunoglobulin A (IgA) antibody to AAF was secreted into the intestinal lumen in response to this immunogen. Immune secretions reduced the transepithelial absorption of a 125I-labeled derivative of AAF by more than half. This reduction of absorption by hapten-specific IgA suggests that oral vaccines against carcinogens and toxicants could be developed for humans.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)
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