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Science 10 March 1989:
Vol. 243. no. 4896, pp. 1319 - 1325
DOI: 10.1126/science.2646715
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Articles

Science, Vol 243, Issue 4896, 1319-1325
Copyright © 1989 by American Association for the Advancement of Science

articles

Model of the origin of rhythmic population oscillations in the hippocampal slice

RD Traub, R Miles, and RK Wong

IBM Research Division, Thomas J. Watson Research Center, Yorktown Heights, NY 10598.

One goal of mammalian neurobiology is to understand the generation of neuronal activity in large networks. Conceptual schemes have been based on either the properties of single cells or of individual synapses. For instance, the intrinsic oscillatory properties of individual thalamic neurons are thought to underlie thalamic spindle rhythms. This issue has been pursued with a computer model of the CA3 region of the hippocampus that is based on known cellular and synaptic properties. Over a wide range of parameters, this model generates a rhythmic activity at a frequency faster than the firing of individual cells. During each rhythmic event, a few cells fire while most other cells receive synchronous synaptic inputs. This activity resembles the hippocampal theta rhythm as well as synchronized synaptic events observed in vitro. The amplitude and frequency of this emergent rhythmic activity depend on intrinsic cellular properties and the connectivity and strength of both excitatory and inhibitory synapses.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Characteristics of Plateau Activity During the Latent Period Prior to Epileptiform Discharges in Slices From Rat Piriform Cortex.
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Retinal Waves Are Governed by Collective Network Properties.
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Sustained and Accelerating Activity at Two Discrete Sites Generate Epileptiform Discharges in Slices of Piriform Cortex.
R. Demir, L. B. Haberly, and M. B. Jackson (1999)
J. Neurosci. 19, 1294-1306
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GABAergic Modulation of Hippocampal Population Activity: Sequence Learning, Place Field Development, and the Phase Precession Effect.
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J Neurophysiol 78, 393-408
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High-frequency network oscillation in the hippocampus.
G Buzsaki, Z Horvath, R Urioste, J Hetke, and K Wise (1992)
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Excitatory synaptic responses mediated by GABAA receptors in the hippocampus.
H. Michelson and R. Wong (1991)
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Intrinsic oscillations of neocortex generated by layer 5 pyramidal neurons.
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