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Science 3 March 1989:
Vol. 243. no. 4895, pp. 1156 - 1159
DOI: 10.1126/science.2646712
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Articles

Science, Vol 243, Issue 4895, 1156-1159
Copyright © 1989 by American Association for the Advancement of Science

articles

Unity in function in the absence of consensus in sequence: role of leader peptides in export

LL Randall and SJ Hardy

Biochemistry/Biophysics Program, Washington State University, Pullman 99164.

Passage of proteins across membranes during export from their site of synthesis to their final destination is mediated by leader peptides that paradoxically exhibit a unity of function in spite of a diversity of sequence. These leader peptides act in at least two stages of the export process: at entry into the pathway and subsequently during translocation across the membrane. How selectivity is imposed on the system in the absence of a consensus among the sequences of leader peptides is the main issue discussed here.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)