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Science 24 February 1989:
Vol. 243. no. 4894, pp. 1071 - 1074
DOI: 10.1126/science.2784226
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Articles

Science, Vol 243, Issue 4894, 1071-1074
Copyright © 1989 by American Association for the Advancement of Science

articles

Neuroanatomical correlates of anticipatory anxiety

EM Reiman, MJ Fusselman, PT Fox, and ME Raichle

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110.

Positron emission tomographic measurements of regional blood flow, a marker of local neuronal activity, were used to investigate the neuroanatomical correlates of a normal emotion. Healthy volunteers were studied before, during, and after anticipation of a painful electric shock. During anticipatory anxiety, there were significant blood flow increases in bilateral temporal poles, the same regions recently implicated in a lactate-induced anxiety attack in patients with panic disorder. Thus, the temporal poles seem to be involved in normal and pathological forms of human anxiety.


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