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Science 24 February 1989: Vol. 243. no. 4894, pp. 1059 - 1062 DOI: 10.1126/science.2646710
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Articles
Science, Vol 243, Issue 4894, 1059-1062
Copyright © 1989 by American Association for the Advancement of Science
A Salmonella locus that controls resistance to microbicidal proteins from phagocytic cells
PI Fields,
EA Groisman,
and
F Heffron
Department of Molecular Biology, Scripps Clinic and Research Foundation, La Jolla, CA 92037.
Facultative intracellular pathogens pose an important health problem because they circumvent a primary defense mechanism of the host: killing and degradation by professional phagocytic cells. A gene of the intracellular pathogen Salmonella typhimurium that is required for virulence and intracellular survival was identified and shown to have a role in resistance to defensins and possibly to other microbicidal mechanisms of the phagocyte. This gene may prove to be a regulatory element in the expression of virulence functions.
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- A PhoP/PhoQ-induced Lipase (PagL) That Catalyzes 3-O-Deacylation of Lipid A Precursors in Membranes of Salmonella typhimurium.
- M. S. Trent, W. Pabich, C. R. H. Raetz, and S. I. Miller (2001)
J. Biol. Chem.
276, 9083-9092
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