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Science 24 February 1989:
Vol. 243. no. 4894, pp. 1059 - 1062
DOI: 10.1126/science.2646710

Articles

Science, Vol 243, Issue 4894, 1059-1062
Copyright © 1989 by American Association for the Advancement of Science


articles

A Salmonella locus that controls resistance to microbicidal proteins from phagocytic cells

PI Fields, EA Groisman, and F Heffron

Department of Molecular Biology, Scripps Clinic and Research Foundation, La Jolla, CA 92037.

Facultative intracellular pathogens pose an important health problem because they circumvent a primary defense mechanism of the host: killing and degradation by professional phagocytic cells. A gene of the intracellular pathogen Salmonella typhimurium that is required for virulence and intracellular survival was identified and shown to have a role in resistance to defensins and possibly to other microbicidal mechanisms of the phagocyte. This gene may prove to be a regulatory element in the expression of virulence functions.


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The Pleiotropic Two-Component Regulatory System PhoP-PhoQ.
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E. L. A. Macfarlane, A. Kwasnicka, and R. E. W. Hancock (2000)
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Regulation of Brucella abortus Catalase.
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Am J Physiol Cell Physiol 277, C351-C358
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Molecular Basis of the Interaction of Salmonella with the Intestinal Mucosa.
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Salt-Resistant Alpha-Helical Cationic Antimicrobial Peptides.
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Inhibition of Salmonella typhimurium Invasion by Host Cell Expression of Secreted Bacterial Invasion Proteins.
S. A. Carlson and B. D. Jones (1998)
Infect. Immun. 66, 5295-5300
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Two-Component Signal Transduction as a Target for Microbial Anti-Infective Therapy.
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Potential Role of Epithelial Cell-Derived Histone H1 Proteins in Innate Antimicrobial Defense in the Human Gastrointestinal Tract.
F. R. A. J. Rose, K. Bailey, J. W. Keyte, W. C. Chan, D. Greenwood, and Y. R. Mahida (1998)
Infect. Immun. 66, 3255-3263
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Adaptive Mutagenesis at ebgR Is Regulated by PhoPQ.
B. G. Hall (1998)
J. Bacteriol. 180, 2862-2865
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Antibacterial agents that inhibit two-component signal transduction systems.
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Murine Salmonellosis Studied by Confocal Microscopy: Salmonella typhimurium Resides Intracellularly Inside Macrophages and Exerts a Cytotoxic Effect on Phagocytes In Vivo.
A. Richter-Dahlfors, A. M.J. Buchan, and B. B. Finlay (1997)
J. Exp. Med. 186, 569-580
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Host responses to pathogenic Salmonella infection..
B D Jones (1997)
Genes & Dev. 11, 679-687
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Characterization of the Bacterial Sensor Protein PhoQ. EVIDENCE FOR DISTINCT BINDING SITES FOR Mg2+ AND Ca2+.
E. G. Vescovi, Y. M. Ayala, E. Di Cera, and E. A. Groisman (1997)
J. Biol. Chem. 272, 1440-1443
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Mode of Action of the Antimicrobial Peptide Indolicidin.
T. J. Falla, D. N. Karunaratne, and R. E.W. Hancock (1996)
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Induction of Salmonella stress proteins upon infection of macrophages.
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