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Science 24 February 1989:
Vol. 243. no. 4894, pp. 1056 - 1059
DOI: 10.1126/science.2922595
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Articles

Science, Vol 243, Issue 4894, 1056-1059
Copyright © 1989 by American Association for the Advancement of Science

articles

Specific recognition of cruciform DNA by nuclear protein HMG1

ME Bianchi, M Beltrame, and G Paonessa

European Molecular Biology Laboratory, Heidleberg, Federal Republic of Germany.

Cruciform DNA, a non-double helix form of DNA, can be generated as an intermediate in genetic recombination as well as from palindromic sequences under the effect of supercoiling. Eukaryotic cells are equipped with a DNA-binding protein that selectively recognizes cruciform DNA. Biochemical and immunological data showed that this protein is HMG1, an evolutionarily conserved, essential, and abundant component of the nucleus. The interaction with a ubiquitous protein points to a critical role for cruciform DNA conformations.


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Pairing of DNA Fragments Containing (GGA:TCC)n Repeats and Promotion by High Mobility Group Protein 1 and Histone H1.
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J. Cell Biol. 137, 19-26
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Characterization of a High Mobility Group 1/2 Homolog in Yeast.
J. Lu, R. Kobayashi, and S. J. Brill (1996)
J. Biol. Chem. 271, 33678-33685
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Maize Chromosomal HMGc. TWO CLOSELY RELATED STRUCTURE-SPECIFIC DNA-BINDING PROTEINS SPECIFY A SECOND TYPE OF PLANT HIGH MOBILITY GROUP BOX PROTEIN.
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J. Biol. Chem. 271, 32900-32906
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Yeast HMG proteins NHP6A/B potentiate promoter-specific transcriptional activation in vivo and assembly of preinitiation complexes in vitro..
T T Paull, M Carey, and R C Johnson (1996)
Genes & Dev. 10, 2769-2781
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GH3 Cell-specific Expression of Kv1.5 Gene.
Y. Mori, E. Folco, and G. Koren (1995)
J. Biol. Chem. 270, 27788-27796
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DNA Looping by Saccharomyces cerevisiae High Mobility Group Proteins NHP6A/B.
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J. Biol. Chem. 270, 8744-8754
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Increased DNA-bending Activity and Higher Affinity DNA Binding of High Mobility Group Protein HMG-1 Prepared without Acids.
J. P. Wagner and D. E. Pettijohn (1995)
J. Biol. Chem. 270, 7394-7398
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Association of poly(CA).poly(TG) DNA fragments into four-stranded complexes bound by HMG1 and 2.
C Gaillard and F Strauss (1994)
Science 264, 433-436
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The nonspecific DNA-binding and -bending proteins HMG1 and HMG2 promote the assembly of complex nucleoprotein structures..
T T Paull, M J Haykinson, and R C Johnson (1993)
Genes & Dev. 7, 1521-1534
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Specific binding of chromosomal protein HMG1 to DNA damaged by the anticancer drug cisplatin.
P. Pil and S. Lippard (1992)
Science 256, 234-237
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Sequence Specificity, Conformation, and Recognition by HMG1 Protein of Major DNA Interstrand Cross-links of Antitumor Dinuclear Platinum Complexes.
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New Insights into Host Factor Requirements for Prokaryotic beta -Recombinase-mediated Reactions in Mammalian Cells.
V. Diaz, P. Servert, I. Prieto, M. A. Gonzalez, C. Martinez-A, J. C. Alonso, and A. Bernad (2001)
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HMG-D and Histone H1 Interplay during Chromatin Assembly and Early Embryogenesis.
S. S. Ner, T. Blank, M. L. Perez-Paralle, T. A. Grigliatti, P. B. Becker, and A. A. Travers (2001)
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   Abstract »    Full Text »    PDF »


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