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Science 17 February 1989:
Vol. 243. no. 4893, pp. 940 - 943
DOI: 10.1126/science.2919285
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Articles

Science, Vol 243, Issue 4893, 940-943
Copyright © 1989 by American Association for the Advancement of Science

articles

Epithelial cell surfaces induce Salmonella proteins required for bacterial adherence and invasion

BB Finlay, F Heffron, and S Falkow

Department of Medical Microbiology, Stanford University School of Medicine, CA 94305.

Salmonella bacteria are capable of entering (invading) and multiplying within eukaryotic cells. Stable adherence to and invasion of epithelial cells by S. choleraesuis and S. typhimurium were found to require de novo synthesis of several new bacterial proteins. This inducible event appears to be a coordinately regulated system dependent on trypsin- and neuraminidase-sensitive structures present on the epithelial cell surface. Mutants of S. choleraesuis and S. typhimurium were unable to synthesize these proteins and did not stably adhere to nor invade eukaryotic cells. Two such S. typhimurium mutants were avirulent in mice, an indication that these proteins are required for Salmonella virulence.


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