Science 10 February 1989: Vol. 243. no. 4892, pp. 811 - 814 DOI: 10.1126/science.2916128

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Articles

Beyond Wavy Hairs: The Epidermal Growth Factor Receptor and Its Ligands in Skin Biology and Pathology.

M. R. Schneider, S. Werner, R. Paus, and E. Wolf (2008)
Am. J. Pathol. 173, 14-24
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7-Chloro-5-(4-hydroxyphenyl)-1-methyl-3-(naphthalen-2-ylmethyl)-4,5-dihydro-1H-benzo[b][1,4]diazepin-2(3H)-one (Bz-423), a Benzodiazepine, Suppresses Keratinocyte Proliferation and Has Antipsoriatic Activity in the Human Skin-Severe, Combined Immunodeficient Mouse Transplant Model.

N. Bhagavathula, K. C. Nerusu, A. Hanosh, M. N. Aslam, T. B. Sundberg, A. W. Opipari Jr., K. Johnson, S. Kang, G. D. Glick, and J. Varani (2008)
J. Pharmacol. Exp. Ther. 324, 938-947
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Differential ErbB1 Signaling in Squamous Cell versus Basal Cell Carcinoma of the Skin.

L. Rittie, S. Kansra, S. W. Stoll, Y. Li, J. E. Gudjonsson, Y. Shao, L. E. Michael, G. J. Fisher, T. M. Johnson, and J. T. Elder (2007)
Am. J. Pathol. 170, 2089-2099
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Srcasm Corrects Fyn-induced Epidermal Hyperplasia by Kinase Down-regulation.

W. Li, C. Marshall, L. Mei, J. Gelfand, and J. T. Seykora (2007)
J. Biol. Chem. 282, 1161-1169
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BP-1107 [{2-[4-(2,4-Dioxo-thiazolidin-5-ylmethyl)-phenoxy]-ethyl}-methyl-amide]: A Novel Synthetic Thiazolidinedione That Inhibits Epidermal Hyperplasia in Psoriatic Skin-Severe-Combined Immunodeficient Mouse Transplants after Topical Application.

N. Bhagavathula, K. C. Nerusu, M. Reddy, C. N. Ellis, A. Chittiboyina, M. Avery, H. A. Pershadsingh, T. W. Kurtz, and J. Varani (2005)
J. Pharmacol. Exp. Ther. 315, 996-1004
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Induction of Keratinocyte Migration via Transactivation of the Epidermal Growth Factor Receptor by the Antimicrobial Peptide LL-37.

S. Tokumaru, K. Sayama, Y. Shirakata, H. Komatsuzawa, K. Ouhara, Y. Hanakawa, Y. Yahata, X. Dai, M. Tohyama, H. Nagai, et al. (2005)
J. Immunol. 175, 4662-4668
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Psoriasis.

M. P. Schön and W.-H. Boehncke (2005)
N. Engl. J. Med. 352, 1899-1912
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A Novel Benzodiazepine Selectively Inhibits Keratinocyte Proliferation and Reduces Retinoid-Induced Epidermal Hyperplasia in Organ-Cultured Human Skin.

J. Varani, N. Bhagavathula, K. C. Nerusu, H. Sherzer, K. Fay, A. E. Boitano, G. D. Glick, K. Johnson, S. Kang, and A. W. Opipari Jr. (2005)
J. Pharmacol. Exp. Ther. 313, 56-63
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Amphiregulin and Epidermal Hyperplasia: Amphiregulin Is Required to Maintain the Psoriatic Phenotype of Human Skin Grafts on Severe Combined Immunodeficient Mice.

N. Bhagavathula, K. C. Nerusu, G. J. Fisher, G. Liu, A. B. Thakur, L. Gemmell, S. Kumar, Z. H. Xu, P. Hinton, N. Tsurushita, et al. (2005)
Am. J. Pathol. 166, 1009-1016
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Autocrine Extracellular Signal-regulated Kinase (ERK) Activation in Normal Human Keratinocytes: Metalloproteinase-mediated Release of Amphiregulin Triggers Signaling from ErbB1 to ERK.

S. Kansra, S. W. Stoll, J. L. Johnson, and J. T. Elder (2004)
Mol. Biol. Cell 15, 4299-4309
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Induction of Disease-associated Keratin 16 Gene Expression by Epidermal Growth Factor Is Regulated through Cooperation of Transcription Factors Sp1 and c-Jun.

Y.-N. Wang and W.-C. Chang (2003)
J. Biol. Chem. 278, 45848-45857
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Blockade of the EGF Receptor Induces a Deranged Chemokine Expression in Keratinocytes Leading to Enhanced Skin Inflammation.

F. Mascia, V. Mariani, G. Girolomoni, and S. Pastore (2003)
Am. J. Pathol. 163, 303-312
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Wound Healing and Expression of Antimicrobial Peptides/Polypeptides in Human Keratinocytes, a Consequence of Common Growth Factors.

O. E. Sorensen, J. B. Cowland, K. Theilgaard-Monch, L. Liu, T. Ganz, and N. Borregaard (2003)
J. Immunol. 170, 5583-5589
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1,25-Dihydroxyvitamin D Down-regulates Cell Membrane Growth- and Nuclear Growth-promoting Signals by the Epidermal Growth Factor Receptor.

J. B. Cordero, M. Cozzolino, Y. Lu, M. Vidal, E. Slatopolsky, P. D. Stahl, M. A. Barbieri, and A. Dusso (2002)
J. Biol. Chem. 277, 38965-38971
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Metalloproteinases Stimulate ErbB-dependent ERK Signaling in Human Skin Organ Culture.

S. W. Stoll, S. Kansra, and J. T. Elder (2002)
J. Biol. Chem. 277, 26839-26845
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Mediation of Systemic Vascular Hyperpermeability in Severe Psoriasis by Circulating Vascular Endothelial Growth Factor.

D. Creamer, M. Allen, R. Jaggar, R. Stevens, R. Bicknell, and J. Barker (2002)
Arch Dermatol 138, 791-796
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Immunopharmacological Potential of Selective Phosphodiesterase Inhibition. I. Differential Regulation of Lipopolysaccharide-Mediated Proinflammatory Cytokine (Interleukin-6 and Tumor Necrosis Factor-alpha ) Biosynthesis in Alveolar Epithelial Cells.

J. J. Haddad, S. C. Land, W. O. Tarnow-Mordi, M. Zembala, D. Kowalczyk, and R. Lauterbach (2002)
J. Pharmacol. Exp. Ther. 300, 559-566
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Matrix-independent Survival of Human Keratinocytes through an EGF Receptor/MAPK-Kinase-dependent Pathway.

M. Jost, T. M. Huggett, C. Kari, and U. Rodeck (2001)
Mol. Biol. Cell 12, 1519-1527
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Clastogenic effects of two tyrosine kinase inhibitors, Tyrphostin 23 and Tyrphostin 46, on a transformed (CHO-K1) and on a primary embryonic Chinese hamster cell line (CHE).

L. Bassi, R. Buzzi, M. Fiore, and F. Palitti (2000)
Mutagenesis 15, 341-347
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Epiregulin, a Novel Member of the Epidermal Growth Factor Family, Is an Autocrine Growth Factor in Normal Human Keratinocytes.

Y. Shirakata, T. Komurasaki, H. Toyoda, Y. Hanakawa, K. Yamasaki, S. Tokumaru, K. Sayama, and K. Hashimoto (2000)
J. Biol. Chem. 275, 5748-5753
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Essential Role of Mitogen-Activated Protein Kinase Pathway and c-Jun Induction in Epidermal Growth Factor-Induced Gene Expression of Human 12-Lipoxygenase.

B.-K. Chen, H.-C. Kung, T.-Y. Tsai, and W.-C. Chang (2000)
Mol. Pharmacol. 57, 153-161
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Regulation of Cyclooxygenase-2 by Interferon gamma and Transforming Growth Factor alpha in Normal Human Epidermal Keratinocytes and Squamous Carcinoma Cells. ROLE OF MITOGEN-ACTIVATED PROTEIN KINASES.

H. Matsuura, M. Sakaue, K. Subbaramaiah, H. Kamitani, T. E. Eling, A. J. Dannenberg, T. Tanabe, H. Inoue, J. Arata, and A. M. Jetten (1999)
J. Biol. Chem. 274, 29138-29148
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Arsenic Enhancement of Skin Neoplasia by Chronic Stimulation of Growth Factors.

D. R. Germolec, J. Spalding, H.-S. Yu, G. S. Chen, P. P. Simeonova, M. C. Humble, A. Bruccoleri, G. A. Boorman, J. F. Foley, T. Yoshida, et al. (1998)
Am. J. Pathol. 153, 1775-1785
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Human Keratinocytes Express Cellular Prion-Related Protein in Vitro and during Inflammatory Skin Diseases.

J. Pammer, W. Weninger, and E. Tschachler (1998)
Am. J. Pathol. 153, 1353-1358
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In Vitro Pharmacological Characterization of PD 166285, a New Nanomolar Potent and Broadly Active Protein Tyrosine Kinase Inhibitor.

R. L. Panek, G. H. Lu, S. R. Klutchko, B. L. Batley, T. K. Dahring, J. M. Hamby, H. Hallak, A. M. Doherty, and J. A. Keiser (1997)
J. Pharmacol. Exp. Ther. 283, 1433-1444
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T. K. Dahring, G. H. Lu, J. M. Hamby, B. L. Batley, A. J. Kraker, and R. L. Panek (1997)
J. Pharmacol. Exp. Ther. 281, 1446-1456
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Cysteines 153 and 154 of Transmembrane Transforming Growth Factor-alpha Are Palmitoylated and Mediate Cytoplasmic Protein Association.

L. Shum, C. W. Turck, and R. Derynck (1996)
J. Biol. Chem. 271, 28502-28508
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Keratinocyte Growth Factor Induces Granulation Tissue in Ischemic Dermal Wounds: Importance of Epithelial-Mesenchymal Cell Interactions.

L. Wu, G. F. Pierce, R. D. Galiano, and T. A. Mustoe (1996)
Arch Surg 131, 660-666
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Transforming Growth Factor Alpha Gene Expression in Cultured Human Keratinocytes Is Unaffected by Cellular Aging.

C. C. Compton, Y. Tong, N. Trookman, H. Zhao, D. Roy, and W. Press (1995)
Arch Dermatol 131, 683-690
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Tyrosine kinase inhibition: an approach to drug development.

A Levitzki and A Gazit (1995)
Science 267, 1782-1788
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Cutaneous Leukocyte Trafficking and Psoriasis.

C. E. M. Griffiths (1994)
Arch Dermatol 130, 494-499
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Transgenic Models of Skin Diseases.

J. A. Rothnagel, D. A. Greenhalgh, X.-J. Wang, K. Sellheyer, J. R. Bickenbach, A. M. Dominey, and D. R. Roop (1993)
Arch Dermatol 129, 1430-1436
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Autocrine Secretion--10 Years Later.

M. B. Sporn and A. B. Roberts (1992)
Ann Intern Med 117, 408-414
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Transforming Growth Factor {alpha} Expression Helps to Distinguish Keratoacanthomas From Squamous Cell Carcinomas.

T. Ho, T. Horn, and E. Finzi (1991)
Arch Dermatol 127, 1167-1171
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Cyclosporine in Psoriasis Treatment: Inhibition of Keratinocyte Cell-Cycle Progression in G1 Independent of Effects on Transforming Growth Factor {alpha}/Epidermal Growth Factor Receptor Pathways.

L. Khandke, J. F. Krane, R. Ashinoff, L. Staiano-Coico, A. Granelli-Piperno, A. D. Luster, D. M. Carter, J. G. Krueger, and A. B. Gottlieb (1991)
Arch Dermatol 127, 1172-1179
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Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation..

R Vassar and E Fuchs (1991)
Genes & Dev. 5, 714-727
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c-Ha-ras and UV Photocarcinogenesis: Do Rays Raise ras?.

J. T. Elder (1990)
Arch Dermatol 126, 379-382
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Cyclosporine Inhibits Basic Fibroblast Growth Factor-Driven Proliferation of Human Endothelial Cells and Keratinocytes.

R. J. Sharpe, K. A. Arndt, S. I. Bauer, and T. E. Maione (1989)
Arch Dermatol 125, 1359-1362
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Growth Factors: Their Biology and Promise in Dermatologic Diseases and Tissue Repair.

M. Rothe and V. Falanga (1989)
Arch Dermatol 125, 1390-1398
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A Morphometric and Histologic Study of the Scalp in Psoriasis: Paradoxical Sebaceous Gland Atrophy and Decreased Hair Shaft Diameters Without Alopecia.

J. T. Headington, A. K. Gupta, M. T. Goldfarb, B. J. Nickoloff, T. A. Hamilton, C. N. Ellis, and J. J. Voorhees (1989)
Arch Dermatol 125, 639-642
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Cloning and Biological Activity of Epigen, a Novel Member of the Epidermal Growth Factor Superfamily.

L. Strachan, J. G. Murison, R. L. Prestidge, M. A. Sleeman, J. D. Watson, and K. D. Kumble (2001)
J. Biol. Chem. 276, 18265-18271
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Functional interaction between c-Jun and promoter factor Sp1 in epidermal growth factor-induced gene expression of human 12(S)-lipoxygenase.

B.-K. Chen and W.-C. Chang (2000)
PNAS 97, 10406-10411
 |  Abstract »  |  Full Text »  |  PDF »

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