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Science 3 February 1989:
Vol. 243. no. 4891, pp. 655 - 657
DOI: 10.1126/science.2536953
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Articles

Science, Vol 243, Issue 4891, 655-657
Copyright © 1989 by American Association for the Advancement of Science

articles

Autocrine induction of collagenase by serum amyloid A-like and beta 2-microglobulin-like proteins

CE Brinckerhoff, TI Mitchell, MJ Karmilowicz, B Kluve-Beckerman, and MD Benson

Department of Medicine, Dartmouth Medical School, Hanover, NH 03756.

Two autocrine proteins of 14 and 12 kilodaltons that induce the synthesis of rabbit fibroblast collagenase were identified. The proteins were purified from serum-free culture medium taken from rabbit synovial fibroblasts stimulated with phorbol myristate acetate. The amino-terminal sequences of the 14- and 12-kilodalton species were approximately 60 to 80 percent homologous with serum amyloid A and beta 2 microglobulin, respectively. The polyacrylamide gel-eluted proteins retained the ability to induce collagenase synthesis in rabbit and human fibroblasts. These autocrine proteins may provide a means to modulate collagenase synthesis in normal remodeling as well as in inflammation and disease states.


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