Science 20 January 1989: Vol. 243. no. 4889, pp. 388 - 390 DOI: 10.1126/science.2492116

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Articles

20-Hydroxy-5,8,11,14-eicosatetraenoic Acid Mediates Endothelial Dysfunction via I{kappa}B Kinase-Dependent Endothelial Nitric-Oxide Synthase Uncoupling.

J. Cheng, C.-C. Wu, K. H. Gotlinger, F. Zhang, J. R. Falck, D. Narsimhaswamy, and M. L. Schwartzman (2010)
J. Pharmacol. Exp. Ther. 332, 57-65
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Heme oxygenase: the key to renal function regulation.

N. G. Abraham, J. Cao, D. Sacerdoti, X. Li, and G. Drummond (2009)
Am J Physiol Renal Physiol 297, F1137-F1152
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Endothelial-specific CYP4A2 overexpression leads to renal injury and hypertension via increased production of 20-HETE.

K. Inoue, K. Sodhi, N. Puri, K. H. Gotlinger, J. Cao, R. Rezzani, J. R. Falck, N. G. Abraham, and M. Laniado-Schwartzman (2009)
Am J Physiol Renal Physiol 297, F875-F884
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Carbon monoxide: vasoconstrictor or vasodilator? That's the question.

G. L. Volti, L. Vanella, D. Gazzolo, and F. Galvano (2008)
Am J Physiol Renal Physiol 295, F901-F903
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Gene Targeting and Heme Oxygenase-1 Expression in Prevention of Hypertension Induced by Angiotensin II.

N. G. Abraham (2008)
Hypertension 52, 618-620
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L-4F treatment reduces adiposity, increases adiponectin levels, and improves insulin sensitivity in obese mice.

S. J. Peterson, G. Drummond, D. H. Kim, M. Li, A. L. Kruger, S. Ikehara, and N. G. Abraham (2008)
J. Lipid Res. 49, 1658-1669
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Deficient renal 20-HETE release in the diabetic rat is not the result of oxidative stress.

Y.-J. Chen, J. Li, and J. Quilley (2008)
Am J Physiol Heart Circ Physiol 294, H2305-H2312
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Regulation of Maternal and Fetal Hemodynamics by Heme Oxygenase in Mice.

H. Zhao, R. J. Wong, T. C. Doyle, N. Nayak, H. J. Vreman, C. H. Contag, and D. K. Stevenson (2008)
Biol Reprod 78, 744-751
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Pharmacological and Clinical Aspects of Heme Oxygenase.

N. G. Abraham and A. Kappas (2008)
Pharmacol. Rev. 60, 79-127
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20-Hydroxyeicosatetraenoic Acid Stimulates Nuclear Factor-{kappa}B Activation and the Production of Inflammatory Cytokines in Human Endothelial Cells.

T. Ishizuka, J. Cheng, H. Singh, M. D. Vitto, V. L. Manthati, J. R. Falck, and M. Laniado-Schwartzman (2008)
J. Pharmacol. Exp. Ther. 324, 103-110
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Vascular Cytochrome P450 4A Expression and 20-Hydroxyeicosatetraenoic Acid Synthesis Contribute to Endothelial Dysfunction in Androgen-Induced Hypertension.

H. Singh, J. Cheng, H. Deng, R. Kemp, T. Ishizuka, A. Nasjletti, and M. L. Schwartzman (2007)
Hypertension 50, 123-129
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Up-Regulation of Heme Oxygenase Provides Vascular Protection in an Animal Model of Diabetes through Its Antioxidant and Antiapoptotic Effects.

A. L. Kruger, S. J. Peterson, M. L. Schwartzman, H. Fusco, J. A. McClung, M. Weiss, S. Shenouda, A. I. Goodman, M. S. Goligorsky, A. Kappas, et al. (2006)
J. Pharmacol. Exp. Ther. 319, 1144-1152
 |  Abstract »  |  Full Text »  |  PDF »

Heme Oxygenase-1: A Novel Drug Target for Atherosclerotic Diseases?.

R. Stocker and M. A. Perrella (2006)
Circulation 114, 2178-2189
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Sustained Normalization of High Blood Pressure in Spontaneously Hypertensive Rats by Implanted Hemin Pump.

R. Wang, R. Shamloul, X. Wang, Q. Meng, and L. Wu (2006)
Hypertension 48, 685-692
 |  Abstract »  |  Full Text »  |  PDF »

Induction of Heme Oxygenase-1 Is Involved in Carbon Monoxide-Mediated Central Cardiovascular Regulation.

W.-C. Lo, P.-J. Lu, W.-Y. Ho, M. Hsiao, and C.-J. Tseng (2006)
J. Pharmacol. Exp. Ther. 318, 8-16
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Anomalous Renal Effects of Tin Protoporphyrin in a Murine Model of Sickle Cell Disease.

J. P. Juncos, J. P. Grande, N. Murali, A. J. Croatt, L. A. Juncos, R. P. Hebbel, Z. S. Katusic, and K. A. Nath (2006)
Am. J. Pathol. 169, 21-31
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Endothelial Dysfunction and Hypertension in Rats Transduced With CYP4A2 Adenovirus.

D. R. Harder and R. J. Roman (2006)
Circ. Res. 98, 866-867
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Endothelial Dysfunction and Hypertension in Rats Transduced With CYP4A2 Adenovirus.

J.-S. Wang, H. Singh, F. Zhang, T. Ishizuka, H. Deng, R. Kemp, M. S. Wolin, T. H. Hintze, N. G. Abraham, A. Nasjletti, et al. (2006)
Circ. Res. 98, 962-969
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Carbon Monoxide: Endogenous Production, Physiological Functions, and Pharmacological Applications.

L. Wu and R. Wang (2005)
Pharmacol. Rev. 57, 585-630
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Programming blood pressure in adult SHR by shifting perinatal balance of NO and reactive oxygen species toward NO: the inverted Barker phenomenon.

S. Racasan, B. Braam, H. A. Koomans, and J. A. Joles (2005)
Am J Physiol Renal Physiol 288, F626-F636
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Overexpression of human heme oxygenase-1 attenuates endothelial cell sloughing in experimental diabetes.

N. G. Abraham, R. Rezzani, L. Rodella, A. Kruger, D. Taller, G. Li Volti, A. I. Goodman, and A. Kappas (2004)
Am J Physiol Heart Circ Physiol 287, H2468-H2477
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Heme Oxygenase-1 Gene Expression Modulates Angiotensin II-Induced Increase in Blood Pressure.

L. Yang, S. Quan, A. Nasjletti, M. Laniado-Schwartzman, and N. G. Abraham (2004)
Hypertension 43, 1221-1226
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Role of the Heme Oxygenases in Abnormalities of the Mesenteric Circulation in Cirrhotic Rats.

D. Sacerdoti, N. G. Abraham, A. O. Oyekan, L. Yang, A. Gatta, and J. C. McGiff (2004)
J. Pharmacol. Exp. Ther. 308, 636-643
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Cardioprotective Actions by a Water-Soluble Carbon Monoxide-Releasing Molecule.

J. E. Clark, P. Naughton, S. Shurey, C. J. Green, T. R. Johnson, B. E. Mann, R. Foresti, and R. Motterlini (2003)
Circ. Res. 93 , e2-e8
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Induction of heme oxygenase-1 and stimulation of cGMP production by hemin in aortic tissues from hypertensive rats.

J. F. Ndisang, L. Wu, W. Zhao, and R. Wang (2003)
Blood 101, 3893-3900
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Acute lead exposure induces renal haeme oxygenase-1 and decreases urinary Na excretion.

H. Vargas, C. Castillo, F. Posadas, and B. Escalante (2003)
Human and Experimental Toxicology 22, 237-244
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Role of Heme Oxygenase-1 in the Regulation of Blood Pressure and Cardiac Function.

Y.-H. Chen, S.-F. Yet, and M. A. Perrella (2003)
Exp Biol Med 228, 447-453
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Alterations in Heme Oxygenase/Carbon Monoxide System in Pulmonary Arteries in Hypertension.

J. F. Ndisang and R. Wang (2003)
Exp Biol Med 228, 557-563
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Differential Regulation of Natriuresis by 20-Hydroxyeicosatetraenoic Acid in Human Salt-Sensitive Versus Salt-Resistant Hypertension.

C. L. Laffer, M. Laniado-Schwartzman, M.-H. Wang, A. Nasjletti, and F. Elijovich (2003)
Circulation 107, 574-578
 |  Abstract »  |  Full Text »  |  PDF »

Modulation of cGMP by human HO-1 retrovirus gene transfer in pulmonary microvessel endothelial cells.

N. G. Abraham, S. Quan, P. A. Mieyal, L. Yang, T. Burke-Wolin, C. J. Mingone, A. I. Goodman, A. Nasjletti, and M. S. Wolin (2002)
Am J Physiol Lung Cell Mol Physiol 283, L1117-L1124
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Antihypertensive effect of mechanism-based inhibition of renal arachidonic acid omega -hydroxylase activity.

F. Xu, W. O. Straub, W. Pak, P. Su, K. G. Maier, M. Yu, R. J. Roman, P. R. Ortiz De Montellano, and D. L. Kroetz (2002)
Am J Physiol Regulatory Integrative Comp Physiol 283, R710-R720
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P450-Dependent Arachidonic Acid Metabolism and Angiotensin II-Induced Renal Damage.

E. Kaergel, D. N. Muller, H. Honeck, J. Theuer, E. Shagdarsuren, A. Mullally, F. C. Luft, and W.-H. Schunck (2002)
Hypertension 40, 273-279
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Selective Regulation of Blood Pressure by Heme Oxygenase-1 in Hypertension.

J. F. Ndisang, W. Zhao, and R. Wang (2002)
Hypertension 40, 315-321
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Renal 20-hydroxyeicosatetraenoic acid synthesis during pregnancy.

M.-H. Wang, B. A. Zand, A. Nasjletti, and M. Laniado-Schwartzman (2002)
Am J Physiol Regulatory Integrative Comp Physiol 282, R383-R389
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Regulation of Cyclooxygenase- and Cytochrome P450-Derived Eicosanoids by Heme Oxygenase in the Rat Kidney.

F. T. Botros, M. Laniado-Schwartzman, and N. G. Abraham (2002)
Hypertension 39, 639-644
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P-450 Metabolites of Arachidonic Acid in the Control of Cardiovascular Function.

R. J. Roman (2002)
Physiol Rev 82, 131-185
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Regulation of human heme oxygenase in endothelial cells by using sense and antisense retroviral constructs.

S. Quan, L. Yang, N. G. Abraham, and A. Kappas (2001)
PNAS 98, 12203-12208
 |  Abstract »  |  Full Text »  |  PDF »

Human Heme Oxygenase-1 Gene Transfer Lowers Blood Pressure and Promotes Growth in Spontaneously Hypertensive Rats.

H. E. Sabaawy, F. Zhang, X. Nguyen, A. ElHosseiny, A. Nasjletti, M. Schwartzman, P. Dennery, A. Kappas, and N. G. Abraham (2001)
Hypertension 38, 210-215
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Epoxyeicosatrienoic Acid-Mediated Renal Vasodilation to Arachidonic Acid Is Enhanced in SHR.

S. I. Pomposiello, M. A. Carroll, J. R. Falck, and J. C. McGiff (2001)
Hypertension 37, 887-893
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CYP4A1 antisense oligonucleotide reduces mesenteric vascular reactivity and blood pressure in SHR.

M.-H. Wang, F. Zhang, J. Marji, B. A. Zand, A. Nasjletti, and M. Laniado-Schwartzman (2001)
Am J Physiol Regulatory Integrative Comp Physiol 280, R255-R261
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Soluble Epoxide Hydrolase Regulates Hydrolysis of Vasoactive Epoxyeicosatrienoic Acids.

Z. Yu, F. Xu, L. M. Huse, C. Morisseau, A. J. Draper, J. W. Newman, C. Parker, L. Graham, M. M. Engler, B. D. Hammock, et al. (2000)
Circ. Res. 87, 992-998
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Cytochrome P450-Dependent Renal Arachidonic Acid Metabolism in Desoxycorticosterone Acetate-Salt Hypertensive Mice.

H. Honeck, V. Gross, B. Erdmann, E. Kargel, R. Neunaber, A. F. Milia, W. Schneider, F. C. Luft, and W.-H. Schunck (2000)
Hypertension 36, 610-616
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A new class of lipid mediators: cytochrome P450 arachidonate metabolites.

M. A Carroll and J. C McGiff (2000)
Thorax 55, 13S-16
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Prevention of Hypoxia-Induced Pulmonary Hypertension by Enhancement of Endogenous Heme Oxygenase-1 in the Rat.

H. Christou, T. Morita, C.-M. Hsieh, H. Koike, B. Arkonac, M. A. Perrella, and S. Kourembanas (2000)
Circ. Res. 86, 1224-1229
 |  Abstract »  |  Full Text »  |  PDF »

Adenoviral Vector-Mediated Transfer of Human Heme Oxygenase in Rats Decreases Renal Heme-Dependent Arachidonic Acid Epoxygenase Activity.

N. G. Abraham, S. Jiang, L. Yang, B. A. Zand, M. Laniado-Schwartzman, J. Marji, G. S. Drummond, and A. Kappas (2000)
J. Pharmacol. Exp. Ther. 293, 494-500
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Increased CYP2J Expression and Epoxyeicosatrienoic Acid Formation in Spontaneously Hypertensive Rat Kidney.

Z. Yu, L. M. Huse, P. Adler, L. Graham, J. Ma, D. C. Zeldin, and D. L. Kroetz (2000)
Mol. Pharmacol. 57, 1011-1020
 |  Abstract »  |  Full Text »

Formation of 20-Hydroxyeicosatetraenoic Acid, a Vasoactive and Natriuretic Eicosanoid, in Human Kidney. ROLE OF CYP4F2 AND CYP4A11.

J. M. Lasker, W. B. Chen, I. Wolf, B. P. Bloswick, P. D. Wilson, and P. K. Powell (2000)
J. Biol. Chem. 275, 4118-4126
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20-HETE agonists and antagonists in the renal circulation.

M. Alonso-Galicia, J. R. Falck, K. M. Reddy, and R. J. Roman (1999)
Am J Physiol Renal Physiol 277, F790-F796
 |  Abstract »  |  Full Text »  |  PDF »

Ontogenetic Aspects of Hypertension Development: Analysis in the Rat.

J. Zicha and J. Kunes (1999)
Physiol Rev 79, 1227-1282
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20-HETE and the kidney: resolution of old problems and new beginnings.

J. C. McGiff and J. Quilley (1999)
Am J Physiol Regulatory Integrative Comp Physiol 277, R607-R623
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Cloning, Enzymatic Characterization, Developmental Expression, and Cellular Localization of a Mouse Cytochrome P450 Highly Expressed in Kidney.

J. Ma, W. Qu, P. E. Scarborough, K. B. Tomer, C. R. Moomaw, R. Maronpot, L. S. Davis, M. D. Breyer, and D. C. Zeldin (1999)
J. Biol. Chem. 274, 17777-17788
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of P-450 4A activity in the glomerulus of the rat.

O. Ito and R. J. Roman (1999)
Am J Physiol Regulatory Integrative Comp Physiol 276, R1749-R1757
 |  Abstract »  |  Full Text »  |  PDF »

Endothelin-1 and CYP450 arachidonate metabolites interact to promote tissue injury in DOCA-salt hypertension.

A. O. Oyekan, K. McAward, J. Conetta, L. Rosenfeld, and J. C. McGiff (1999)
Am J Physiol Regulatory Integrative Comp Physiol 276, R766-R775
 |  Abstract »  |  Full Text »  |  PDF »

Heme Oxygenase-1–Derived Carbon Monoxide Contributes to the Suppression of Acute Hypertensive Responses In Vivo.

R. Motterlini, A. Gonzales, R. Foresti, J. E. Clark, C. J. Green, and R. M. Winslow (1998)
Circ. Res. 83, 568-577
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of renal arachidonic acid omega -hydroxylase activity with ABT reduces blood pressure in the SHR.

P. Su, K. M. Kaushal, and D. L. Kroetz (1998)
Am J Physiol Regulatory Integrative Comp Physiol 275, R426-R438
 |  Abstract »  |  Full Text »  |  PDF »

Cytochrome P450-Derived Arachidonic Acid Metabolism in the Rat Kidney: Characterization of Selective Inhibitors.

M.-H. Wang, E. Brand-Schieber, B. A. Zand, X. Nguyen, J. R. Falck, N. Balu, and M. L. Schwartzman (1998)
J. Pharmacol. Exp. Ther. 284, 966-973
 |  Abstract »  |  Full Text »

Localization of cytochrome P-450 4A isoforms along the rat nephron.

O. Ito, M. Alonso-Galicia, K. A. Hopp, and R. J. Roman (1998)
Am J Physiol Renal Physiol 274, F395-F404
 |  Abstract »  |  Full Text »  |  PDF »

Developmentally Regulated Expression of the CYP4A Genes in the Spontaneously Hypertensive Rat Kidney.

D. L. Kroetz, L. M. Huse, A. Thuresson, and M. P. Grillo (1997)
Mol. Pharmacol. 52, 362-372
 |  Abstract »  |  Full Text »

Renal Cytochrome P4504A Activity and Salt Sensitivity in Spontaneously Hypertensive Rats.

D. E. Stec, M. R. Trolliet, J. E. Krieger, H. J. Jacob, and R. J. Roman (1996)
Hypertension 27, 1329-1336
 |  Abstract »  |  Full Text »

The Role of the Kidney in Hypertension.

A. W. Cowley Jr and R. J. Roman (1996)
JAMA 275, 1581-1589
 |  Abstract »  |  PDF »

20-HETE Requires Increased Vascular Tone to Constrict Rabbit Afferent Arterioles.

S. Arima, K. Omata, S. Ito, K. Tsunoda, and K. Abe (1996)
Hypertension 27, 781-785
 |  Abstract »  |  Full Text »

A Heme Oxygenase Product, Presumably Carbon Monoxide, Mediates a Vasodepressor Function in Rats.

R. A. Johnson, M. Lavesa, B. Askari, N. G. Abraham, and A. Nasjletti (1995)
Hypertension 25, 166-169
 |  Abstract »  |  Full Text »

Exacerbation of Chronic Renovascular Hypertension and Acute Renal Failure in Heme Oxygenase-1-Deficient Mice.

P. Wiesel, A. P. Patel, I. M. Carvajal, Z. Y. Wang, A. Pellacani, K. Maemura, N. DiFonzo, H. G. Rennke, M. D. Layne, S.-F. Yet, et al. (2001)
Circ. Res. 88, 1088-1094
 |  Abstract »  |  Full Text »  |  PDF »

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