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Science 20 January 1989:
Vol. 243. no. 4889, pp. 388 - 390
DOI: 10.1126/science.2492116
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Articles

Science, Vol 243, Issue 4889, 388-390
Copyright © 1989 by American Association for the Advancement of Science

articles

Treatment with tin prevents the development of hypertension in spontaneously hypertensive rats

D Sacerdoti, B Escalante, NG Abraham, JC McGiff, RD Levere, and ML Schwartzman

Department of Pharmacology, New York Medical College, Valhalla 10595.

Cytochrome P-450-dependent metabolites of arachidonic acid (AA) increased in the kidneys of young, spontaneously hypertensive rats (SHRs) during the period of rapid elevation of blood pressure (BP) but not in adult SHRs or in Wistar Kyoto rats (WKYs) with normal BP. Treatment of SHRs and WKYs with stannous chloride (SnCl2), which selectively depletes renal cytochrome P-450, restored BP to normal, coincident with a natriuresis, in young but not in adult SHRs and did not affect either BP or sodium excretion in WKYs. Depletion of renal cytochrome P-450 was associated with decreased generation of these AA metabolites only in young SHRs. The antihypertensive effect of SnCl2 in young SHRs was greatly reduced by prevention of its cytochrome P-450-depleting action.


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