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Science 20 January 1989:
Vol. 243. no. 4889, pp. 383 - 385
DOI: 10.1126/science.2463673
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Articles

Science, Vol 243, Issue 4889, 383-385
Copyright © 1989 by American Association for the Advancement of Science

articles

Atrial natriuretic peptide inhibits a cation channel in renal inner medullary collecting duct cells

DB Light, EM Schwiebert, KH Karlson, and BA Stanton

Department of Physiology, Dartmouth Medical School, Hanover, NH 03756.

The patch-clamp technique was used to examine the effects of atrial natriuretic peptide (ANP) and its second messenger guanosine 3',5'-monophosphate (cGMP) on an amiloride-sensitive cation channel in the apical membrane of renal inner medullary collecting duct cells. Both ANP (10(-11) M) and dibutyryl guanosine 3',5'-monophosphate (10(-4) M) inhibited the channel in cell-attached patches, and cGMP (10(-5) M) inhibited the channel in inside-out patches. The inner medullary collecting duct is the first tissue in which ANP, via its second messenger cGMP, has been shown to regulate single ion channels. The results suggest that the natriuretic action of ANP is related in part to cGMP-mediated inhibition of electrogenic Na+ absorption by the inner medullary collecting duct.


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