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Science 20 January 1989: Vol. 243. no. 4889, pp. 355 - 361 DOI: 10.1126/science.2783497
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Articles
Science, Vol 243, Issue 4889, 355-361
Copyright © 1989 by American Association for the Advancement of Science
Contingent genetic regulatory events in T lymphocyte activation
GR Crabtree
Department of Pathology, Stanford University Medical School, CA.
Interaction of antigen in the proper histocompatibility context with the T lymphocyte antigen receptor leads to an orderly series of events resulting in morphologic change, proliferation, and the acquisition of immunologic function. In most T lymphocytes two signals are required to initiate this process, one supplied by the antigen receptor and the other by accessory cells or agents that activate protein kinase C. Recently, DNA sequences have been identified that act as response elements for one or the other of the two signals, but do not respond to both signals. The fact that these sequences lie within the control regions of the same genes suggests that signals originating from separate cell membrane receptors are integrated at the level of the responsive gene. The view is put forth that these signals initiate a contingent series of gene activations that bring about proliferation and impart immunologic function.
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- T. F. Bruno, D. E. Buser, R. M. Syme, D. E. Woods, and C. H. Mody (1998)
Infect. Immun.
66, 3072-3079
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- V7 (CD101) Ligation Inhibits TCR/CD3-Induced IL-2 Production by Blocking Ca2+ Flux and Nuclear Factor of Activated T Cell Nuclear Translocation.
- L. R. B. Soares, L. Tsavaler, A. Rivas, and E. G. Engleman (1998)
J. Immunol.
161, 209-217
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- T Lymphocyte Activation Signals for Interleukin-2 Production Involve Activation of MKK6-p38 and MKK7-SAPK/JNK Signaling Pathways Sensitive to Cyclosporin A.
- S. Matsuda, T. Moriguchi, S. Koyasu, and E. Nishida (1998)
J. Biol. Chem.
273, 12378-12382
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- J. Fan, P. Nishanian, E. C. Breen, M. McDonald, and J. L. Fahey (1998)
Clin. Vaccine Immunol.
5, 335-340
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- Turnover of CD4+ and CD8+ T Lymphocytes in HIV-1 Infection as Measured by Ki-67 Antigen.
- N. Sachsenberg, A. S. Perelson, S. Yerly, G. A. Schockmel, D. Leduc, B. Hirschel, and L. Perrin (1998)
J. Exp. Med.
187, 1295-1303
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- Progression to the G1b Phase of the Cell Cycle Is Required for Completion of Human Immunodeficiency Virus Type 1 Reverse Transcription in T Cells.
- Y. D. Korin and J. A. Zack (1998)
J. Virol.
72, 3161-3168
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- Characterization of Signal Transduction Through the TCR-{zeta} Chain Following T Cell Stimulation with Analogue Peptides of Type II Collagen 260-267.
- B. Tang, L. K. Myers, E. F. Rosloniec, K. B. Whittington, J. M. Stuart, and A. H. Kang (1998)
J. Immunol.
160, 3135-3142
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- The Tpl-2 protooncoprotein activates the nuclear factor of activated T cells and induces interleukin 2 expression in T cell lines.
- C. Tsatsanis, C. Patriotis, S. E. Bear, and P. N. Tsichlis (1998)
PNAS
95, 3827-3832
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- Translational control: a general mechanism for gene regulation during T cell activation.
- J. A. Garcia-Sanz, W. Mikulits, A. Livingstone, I. Lefkovits, and E. W. Müllner (1998)
FASEB J
12, 299-306
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- Prostaglandin E2 Modulation of p59fyn Tyrosine Kinase in T Lymphocytes During Sepsis.
- M. A. Choudhry, S. Uddin, and M. M. Sayeed (1998)
J. Immunol.
160, 929-935
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- p130 Is Dispensable in Peripheral T Lymphocytes: Evidence for Functional Compensation by p107 and pRB.
- G. J. Mulligan, J. Wong, and T. Jacks (1998)
Mol. Cell. Biol.
18, 206-220
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- Cytotoxic T Lymphocyte Antigen 4 (CTLA-4) Interferes with Extracellular Signal-regulated Kinase (ERK) and Jun NH2-terminal Kinase (JNK) Activation, but Does Not Affect Phosphorylation of T Cell Receptor {zeta} and ZAP70.
- C. R. Calvo, D. Amsen, and A. M. Kruisbeek (1997)
J. Exp. Med.
186, 1645-1653
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- Impaired CD28-mediated Interleukin 2 Production and Proliferation in Stress Kinase SAPK/ERK1 Kinase (SEK1)/Mitogen-activated Protein Kinase Kinase 4 (MKK4)-deficient T Lymphocytes.
- H. Nishina, M. Bachmann, A. J. Oliveira-dos-Santos, I. Kozieradzki, K. D. Fischer, B. Odermatt, A. Wakeham, A. Shahinian, H. Takimoto, A. Bernstein, et al. (1997)
J. Exp. Med.
186, 941-953
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- TLiSA1 (PTA1) Activation Antigen Implicated in T Cell Differentiation and Platelet Activation Is a Member of the Immunoglobulin Superfamily Exhibiting Distinctive Regulation of Expression.
- P. D. Sherrington, J. L. Scott, B. Jin, D. Simmons, D. J. Dorahy, J. Lloyd, J. H. Brien, R. H. Aebersold, J. Adamson, M. Zuzel, et al. (1997)
J. Biol. Chem.
272, 21735-21744
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- Role of A2a Extracellular Adenosine Receptor-Mediated Signaling in Adenosine-Mediated Inhibition of T-Cell Activation and Expansion.
- S. Huang, S. Apasov, M. Koshiba, and M. Sitkovsky (1997)
Blood
90, 1600-1610
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- Identification of Transcription Factor Binding Sites Important in the Regulation of the Human Interleukin-5 Gene.
- K. S. Stranick, D. N. Zambas, A. S. Uss, R. W. Egan, M. M. Billah, and S. P. Umland (1997)
J. Biol. Chem.
272, 16453-16465
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- Perturbation of the T Lymphocyte Lineage In Transgenic Mice Expressing a Constitutive Repressor of Nuclear Factor (NF)-{kappa}B.
- M. R. Boothby, A. L. Mora, D. C. Scherer, J. A. Brockman, and D. W. Ballard (1997)
J. Exp. Med.
185, 1897-1907
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- Mitogenic stimulation of resting T cells causes rapid phosphorylation of the transcription factor LSF and increased DNA-binding activity..
- J L Volker, L E Rameh, Q Zhu, J DeCaprio, and U Hansen (1997)
Genes & Dev.
11, 1435-1446
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- Intermediate Affinity Interleukin-2 Receptor Mediates Survival via a Phosphatidylinositol 3-Kinase-dependent Pathway.
- A. Gonzalez-Garcia, I. Merida, C. Martinez-A, and A. C. Carrera (1997)
J. Biol. Chem.
272, 10220-10226
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- Constitutive Binding of the Transcription Factor Interleukin-2 (IL-2) Enhancer Binding Factor to the IL-2 Promoter.
- A. Nirula, D. J. Moore, and R. B. Gaynor (1997)
J. Biol. Chem.
272, 7736-7745
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