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Science 13 January 1989:
Vol. 243. no. 4888, pp. 214 - 217
DOI: 10.1126/science.2911734
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Articles
Science, Vol 243, Issue 4888, 214-217
Copyright © 1989 by American Association for the Advancement of Science
A new cluster of genes within the human major histocompatibility complex
T Spies,
G Blanck,
M Bresnahan,
J Sands,
and
JL Strominger
Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, MA 02138.
A 435-kilobase (kb) DNA segment, which is centromeric to HLA-B in the human major histocompatibility complex, was isolated by chromosome walking with overlapping cosmids. Within the cloned region, the genes for the tumor necrosis factors (TNFs) alpha and beta and HLA-B were 210 kb apart. The human homolog of a mouse gene, B144, was located next to TNF alpha. Moreover, the presence of additional genes was suggested by a large cluster of CpG islands. With cosmid probes, several distinct transcripts were detected in RNA samples from a variety of cell lines. Altogether, five novel genes were identified by isolation of corresponding complementary DNA clones. These "HLA-B-associated transcripts" (BATs) were mapped to different locations within a 160-kb region that includes the genes for TNF alpha and TNF beta. The presence of the genes for BAT1 and BAT5 in the vicinity of HLA-B again raises the question of which gene in this region determines susceptibility to ankylosing spondylitis.
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