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Science 13 January 1989:
Vol. 243. no. 4888, pp. 192 - 197
DOI: 10.1126/science.2911732
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Articles

Science, Vol 243, Issue 4888, 192-197
Copyright © 1989 by American Association for the Advancement of Science

articles

Molecular sorting in the secretory pathway

KN Chung, P Walter, GW Aponte, and HP Moore

Department of Physiology Anatomy, University of California, Berkeley 94720.

Proteins can be secreted from animal cells by either a constitutive or a regulated pathway; those destined for regulated secretion are actively sorted into dense-core secretory granules. Although sorting is generally assumed to be accomplished by specific carriers, the nature of these carriers remains elusive. In this study, peptide hormones were used as affinity ligands to purify a set of 25-kilodalton proteins from canine pancreatic tissue. Their ligand specificities and patterns of expression have the characteristics of sorting carriers.


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