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Science 6 January 1989:
Vol. 243. no. 4887, pp. 80 - 83
DOI: 10.1126/science.2563174
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Articles

Science, Vol 243, Issue 4887, 80-83
Copyright © 1989 by American Association for the Advancement of Science

articles

Chromosome mapping and expression of a putative testis-determining gene in mouse

CM Nagamine, KM Chan, CA Kozak, and YF Lau

Howard Hughes Medical Institute, University of California, San Francisco 94143.

Isolation and mapping of a mouse complementary DNA sequence (mouse Y-finger) encoding a multiple, potential zinc-binding, finger protein homologous to the candidate human testis-determining factor gene is reported. Four similar sequences were identified in Hind III-digested mouse genomic DNA. Two (7.2 and 2.0 kb) were mapped to the Y chromosome. Only the 2.0-kb fragment, however, was correlated with testis determination. Polymerase chain reaction analysis suggests both Y loci are transcribed in adult testes. A 3.6-kb fragment was mapped to the X chromosome between the T16H and T6R1 translocation breakpoints, and a fourth (6.0 kb) was mapped to chromosome 10. Hence, mYfin sequences have been duplicated several times in the mouse, although they are not duplicated in humans.


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