Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 6 January 1989:
Vol. 243. no. 4887, pp. 78 - 80
DOI: 10.1126/science.2563173
Prev | Table of Contents | Next

Articles

Science, Vol 243, Issue 4887, 78-80
Copyright © 1989 by American Association for the Advancement of Science

articles

Duplication, deletion, and polymorphism in the sex-determining region of the mouse Y chromosome

G Mardon, R Mosher, CM Disteche, Y Nishioka, A McLaren, and DC Page

Whitehead Institute, Nine Cambridge Center, MA 02142.

The ZFY gene in the sex-determining region of the human Y chromosome encodes a "zinc-finger" protein that may be the testis-determining factor, TDF. Although the Y chromosomes of most placental mammals carry a single homolog of ZFY, the mouse Y chromosome has two homologs, both in the sex-determining (Sxr) region. Zfy-1 alone may suffice to determine maleness; Zfy-2 is dispensable, as it was deleted in an Sxr variant that retains sex-determining function but has lost other genes. Both loci mapped near the centromere of the mouse Y chromosome. The Y chromosomes of the subspecies Mus musculus musculus and M. m. domesticus were distinguishable by a Zfy-1 restriction fragment polymorphism, which can be used to study their differing interactions with autosomal sex-determining genes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Differential Rates of Evolution for the ZFY-Related Zinc Finger Genes, Zfy, Zfx, and Zfa in the Mouse Genus Mus.
P. K. Tucker, R. M. Adkins, and J. S. Rest (2003)
Mol. Biol. Evol. 20, 999-1005
   Abstract »    Full Text »    PDF »
Patterns of Y and X Chromosome DNA Sequence Divergence During the Felidae Radiation.
J. P. Slattery and S. J. O'Brien (1998)
Genetics 148, 1245-1255
   Abstract »    Full Text »    PDF »
Zfx mutation results in small animal size and reduced germ cell number in male and female mice.
S. Luoh, P. Bain, R. Polakiewicz, M. Goodheart, H Gardner, R Jaenisch, and D. Page (1997)
Development 124, 2275-2284
   Abstract »    PDF »
Expression of a mouse Zfy-1/lacZ transgene in the somatic cells of the embryonic gonad and germ cells of the adult testis.
B. Zambrowicz, J. Zimmermann, C. Harendza, E. Simpson, D. Page, R. Brinster, and R. Palmiter (1994)
Development 120, 1549-1559
   Abstract »    PDF »
A Y-chromosomal effect on blastocyst cell number in mice.
P. S. Burgoyne (1993)
Development 117, 341-345
   Abstract »    PDF »
The two candidate testis-determining Y genes (Zfy-1 and Zfy-2) are differentially expressed in fetal and adult mouse tissues..
C M Nagamine, K Chan, L E Hake, and Y F Lau (1990)
Genes & Dev. 4, 63-74
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)