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Science 6 January 1989:
Vol. 243. no. 4887, pp. 75 - 77
DOI: 10.1126/science.2911720
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Articles

Science, Vol 243, Issue 4887, 75-77
Copyright © 1989 by American Association for the Advancement of Science

articles

Phylogenetic meaning of the kingdom concept: an unusual ribosomal RNA from Giardia lamblia

ML Sogin, JH Gunderson, HJ Elwood, RA Alonso, and DA Peattie

National Jewish Center for Immunology and Respiratory Medicine, Department of Pediatrics, Denver, CO 80206.

An analysis of the small subunit ribosomal RNA (16S-like rRNA) from the protozoan Giardia lamblia provided a new perspective on the evolution of nucleated cells. Evolutionary distances estimated from sequence comparisons between the 16S-like rRNAs of Giardia lamblia and other eukaryotes exceed similar estimates of evolutionary diversity between archaebacteria and eubacteria and challenge the phylogenetic significance of multiple eukaryotic kingdoms. The Giardia lamblia 16S-like rRNA has retained many of the features that may have been present in the common ancestor of eukaryotes and prokaryotes.


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   Abstract »    Full Text »    PDF »
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(2000)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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Science 284, 2124-2128
   Abstract »    Full Text »
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   Abstract »    Full Text »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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J.-H. Park, M. R. Edwards, and P. J. Schofield (1998)
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   Abstract »    Full Text »
A base called J.
L. Simpson (1998)
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   Full Text »    PDF »
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L. A. Knodler, E. O. Sekyere, T. S. Stewart, P. J. Schofield, and M. R. Edwards (1998)
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   Abstract »    Full Text »    PDF »
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A. J. Roger, S. G. Svard, J. Tovar, C. G. Clark, M. W. Smith, F. D. Gillin, and M. L. Sogin (1998)
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   Abstract »    Full Text »    PDF »
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PNAS 94, 4520-4525
   Abstract »    Full Text »    PDF »
Telomeric organization of a variable and inducible toxin gene family in the ancient eukaryote Giardia duodenalis..
P Upcroft, N Chen, and J A Upcroft (1997)
Genome Res. 7, 37-46
   Abstract »    PDF »
Endopolyphosphatases for Long Chain Inorganic Polyphosphate in Yeast and Mammals.
KrishnanandD. Kumble and A. Kornberg (1996)
J. Biol. Chem. 271, 27146-27151
   Abstract »    Full Text »    PDF »
A Soluble Secretory Reporter System in Trypanosoma brucei. STUDIES ON ENDOPLASMIC RETICULUM TARGETING.
J. D. Bangs, E. M. Brouch, D. M. Ransom, and J. L. Roggy (1996)
J. Biol. Chem. 271, 18387-18393
   Abstract »    Full Text »    PDF »
Widespread Use of the Glu-tRNAGln Transamidation Pathway among Bacteria. A MEMBER OF THE alpha PURPLE BACTERIA LACKS GLUTAMINYL-tRNA SYNTHETASE.
Y. Gagnon, L. Lacoste, N. Champagne, and J. Lapointe (1996)
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   Abstract »    Full Text »    PDF »
Identification of endoplasmic reticulum in the primitive eukaryote Giardia lamblia using cryoelectron microscopy and antibody to Bip.
B. Soltys, M Falah, and R. Gupta (1996)
J. Cell Sci. 109, 1909-1917
   Abstract »    PDF »
Identification of a Novel Giardia lamblia Cyst Wall Protein with Leucine-rich Repeats.
H. D. Luján, M. R. Mowatt, J. T. Conrad, B. Bowers, and T. E. Nash (1995)
J. Biol. Chem. 270, 29307-29313
   Abstract »    Full Text »    PDF »
Developmental Induction of Golgi Structure and Function in the Primitive Eukaryote Giardia lamblia.
H. D. Luján, A. Marotta, M. R. Mowatt, N. Sciaky, J. Lippincott-Schwartz, and T. E. Nash (1995)
J. Biol. Chem. 270, 4612-4618
   Abstract »    Full Text »    PDF »
Giardia gene predicts a 183 kDa nucleotide-binding head-stalk protein.
J Marshall and D. Holberton (1995)
J. Cell Sci. 108, 2683-2692
   Abstract »    PDF »
Cell cycle-specific induction of an 89 kDa serine/threonine protein kinase activity in Trypanosoma brucei.
M. Gale, V. Carter, and M. Parsons (1994)
J. Cell Sci. 107, 1825-1832
   Abstract »    PDF »
Unusual strategies of gene expression and control in parasites.
T. Nilsen (1994)
Science 264, 1868-1869
   PDF »
RNA editing and the evolution of parasites.
L Simpson and D. Maslov (1994)
Science 264, 1870-1871
   PDF »
The protein phosphatase inhibitor okadaic acid induces defects in cytokinesis and organellar genome segregation in Trypanosoma brucei.
A Das, M Gale, V Carter, and M Parsons (1994)
J. Cell Sci. 107, 3477-3483
   Abstract »    PDF »
Transport of a lysosomal membrane glycoprotein from the Golgi to endosomes and lysosomes via the cell surface in African trypanosomes.
M. Brickman and A. Balber (1994)
J. Cell Sci. 107, 3191-3200
   Abstract »    PDF »
Molecular cloning and cellular localization of a BiP homologue in Trypanosoma brucei. Divergent ER retention signals in a lower eukaryote.
J. Bangs, L Uyetake, M. Brickman, A. Balber, and J. Boothroyd (1993)
J. Cell Sci. 105, 1101-1113
   Abstract »    PDF »
Control of Antigenic Variation in African Trypanosomas.
P. Borst, J.H. Gommers-Ampt, M.J.L. Ligtenberg, G. Rudenko, R. Kieft, M.C. Taylor, P.A. Blundell, and F. van Leeuwen (1993)
Cold Spring Harb Symp Quant Biol 58, 105-114
   Abstract »    PDF »
Megascopic eukaryotic algae from the 2.1-billion-year-old negaunee iron-formation, Michigan.
T. Han and B Runnegar (1992)
Science 257, 232-235
   Abstract »    PDF »
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A. Knoll (1992)
Science 256, 622-627
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E. S. Abel, B. J. Davids, L. D. Robles, C. E. Loflin, F. D. Gillin, and R. Chakrabarti (2001)
J. Biol. Chem. 276, 10320-10329
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S. Bunjun, C. Stathopoulos, D. Graham, B. Min, M. Kitabatake, A. L. Wang, C. C. Wang, C. P. Vivares, L. M. Weiss, and D. Soll (2000)
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