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Science 6 January 1989:
Vol. 243. no. 4887, pp. 51 - 56
DOI: 10.1126/science.2492113
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Articles

Science, Vol 243, Issue 4887, 51-56
Copyright © 1989 by American Association for the Advancement of Science

articles

Innovative approaches to plasminogen activator therapy

E Haber, T Quertermous, GR Matsueda, and MS Runge

Cardiac Unit, Massachusetts General Hospital, Boston 02114.

Plasminogen activator therapy for acute myocardial infarction has become standard medical practice. Bleeding complications, however, limit the utility of the currently available agents. This article reviews how the tools of molecular biology and protein engineering are being used to develop safer and more effective plasminogen activators.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A Fast-acting, Modular-structured Staphylokinase Fusion with Kringle-1 from Human Plasminogen as the Fibrin-targeting Domain Offers Improved Clot Lysis Efficacy.
S.-C. Wu, F. J. Castellino, and S.-L. Wong (2003)
J. Biol. Chem. 278, 18199-18206
   Abstract »    Full Text »    PDF »
A catalytic switch and the conversion of streptokinase to a fibrin-targeted plasminogen activator.
G. L. Reed, A. K. Houng, L. Liu, B. Parhami-Seren, L. H. Matsueda, S. Wang, and L. Hedstrom (1999)
PNAS 96, 8879-8883
   Abstract »    Full Text »    PDF »
Thrombolysis for Acute Myocardial Infarction.
H. D. White and F. J. J. Van de Werf (1998)
Circulation 97, 1632-1646
   Abstract »    Full Text »    PDF »
Fibrin-Selective Thrombolytic Therapy for Acute Myocardial Infarction.
D. Collen (1996)
Circulation 93, 857-865
   Full Text »
Isolation of a High Affinity Inhibitor of Urokinase-type Plasminogen Activator by Phage Display of Ecotin.
C.-I W. Q. Y. and Charles S. Craik and C. I. Wang (1995)
J. Biol. Chem. 270, 12250-12256
   Abstract »    Full Text »    PDF »
Deep-Vein Thrombosis.
E. E. Weinmann and E. W. Salzman (1994)
N. Engl. J. Med. 331, 1630-1641
   Full Text »
The Search for the Ideal Thrombolytic Agent: Maximize the Benefit and Minimize the Risk.
S. J. Gardell (1993)
Toxicol Pathol 21, 190-198
   Abstract »    PDF »
Monoclonal antibodies in diagnosis and therapy.
T. Waldmann (1991)
Science 252, 1657-1662
   Abstract »    PDF »


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