Science 16 December 1988: Vol. 242. no. 4885, pp. 1563 - 1566 DOI: 10.1126/science.3201247

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Articles

Role of Kaposi's Sarcoma-Associated Herpesvirus C-Terminal LANA Chromosome Binding in Episome Persistence.

B. Kelley-Clarke, E. De Leon-Vazquez, K. Slain, A. J. Barbera, and K. M. Kaye (2009)
J. Virol. 83, 4326-4337
 |  Abstract »  |  Full Text »  |  PDF »

Proto-oncogene FBI-1 (Pokemon/ZBTB7A) Represses Transcription of the Tumor Suppressor Rb Gene via Binding Competition with Sp1 and Recruitment of Co-repressors.

B.-N. Jeon, J.-Y. Yoo, W.-I. Choi, C.-E. Lee, H.-G. Yoon, and M.-W. Hur (2008)
J. Biol. Chem. 283, 33199-33210
 |  Abstract »  |  Full Text »  |  PDF »

The extreme COOH terminus of the retinoblastoma tumor suppressor protein pRb is required for phosphorylation on Thr-373 and activation of E2F.

L. L. Gorges, N. H. Lents, and J. J. Baldassare (2008)
Am J Physiol Cell Physiol 295, C1151-C1160
 |  Abstract »  |  Full Text »  |  PDF »

The Retinoblastoma Protein Tumor Suppressor Is Important for Appropriate Osteoblast Differentiation and Bone Development.

S. D. Berman, T. L. Yuan, E. S. Miller, E. Y. Lee, A. Caron, and J. A. Lees (2008)
Mol. Cancer Res. 6, 1440-1451
 |  Abstract »  |  Full Text »  |  PDF »

Zoledronic Acid Activates the DNA S-Phase Checkpoint and Induces Osteosarcoma Cell Death Characterized by Apoptosis-Inducing Factor and Endonuclease-G Translocation Independently of p53 and Retinoblastoma Status.

B. Ory, F. Blanchard, S. Battaglia, F. Gouin, F. Redini, and D. Heymann (2007)
Mol. Pharmacol. 71, 333-343
 |  Abstract »  |  Full Text »  |  PDF »

Overexpression of Cox-2 in Human Osteosarcoma Cells Decreases Proliferation and Increases Apoptosis..

Z. Xu, S. Choudhary, O. Voznesensky, M. Mehrotra, M. Woodard, M. Hansen, H. Herschman, and C. Pilbeam (2006)
Cancer Res. 66, 6657-6664
 |  Abstract »  |  Full Text »  |  PDF »

A retinoblastoma ortholog controls stalk/spore preference in Dictyostelium.

H. MacWilliams, K. Doquang, R. Pedrola, G. Dollman, D. Grassi, T. Peis, A. Tsang, and A. Ceccarelli (2006)
Development 133, 1287-1297
 |  Abstract »  |  Full Text »  |  PDF »

Ikaros Induces Quiescence and T-Cell Differentiation in a Leukemia Cell Line.

K. L. Kathrein, R. Lorenz, A. M. Innes, E. Griffiths, and S. Winandy (2005)
Mol. Cell. Biol. 25, 1645-1654
 |  Abstract »  |  Full Text »  |  PDF »

Biology and Therapeutic Advances for Pediatric Osteosarcoma.

N. Marina, M. Gebhardt, L. Teot, and R. Gorlick (2004)
Oncologist 9, 422-441
 |  Abstract »  |  Full Text »  |  PDF »

A rare combination consisting of aldosterone-producing adenoma and adrenal myelolipoma in a patient with heterozygosity for retinoblastoma (RB) gene.

C. Caliumi, G. De Toma, A. Bossini, R. Cianci, C. Bosman, M. Genuardi, S. Cerci, and C. Letizia (2004)
Journal of Renin-Angiotensin-Aldosterone System 5, 45-48
 |  Abstract »  |  PDF »

Loss of pRb2/p130 Expression Is Associated with Unfavorable Clinical Outcome in Lung Cancer.

M. Caputi, A. M. Groeger, V. Esposito, A. De Luca, V. Masciullo, A. Mancini, F. Baldi, E. Wolner, and A. Giordano (2002)
Clin. Cancer Res. 8, 3850-3856
 |  Abstract »  |  Full Text »  |  PDF »

Evidence for a Hereditary Neuroblastoma Predisposition Locus at Chromosome 16p12-13.

J. M. Maris, M. J. Weiss, Y. Mosse, G. Hii, C. Guo, P. S. White, M. D. Hogarty, T. Mirensky, G. M. Brodeur, T. R. Rebbeck, et al. (2002)
Cancer Res. 62, 6651-6658
 |  Abstract »  |  Full Text »  |  PDF »

Degradation of the Retinoblastoma Tumor Suppressor by the Human Papillomavirus Type 16 E7 Oncoprotein Is Important for Functional Inactivation and Is Separable from Proteasomal Degradation of E7.

S. L. Gonzalez, M. Stremlau, X. He, J. R. Basile, and K. Munger (2001)
J. Virol. 75, 7583-7591
 |  Abstract »  |  Full Text »  |  PDF »

Cloning and Characterization of a Novel Pregnancy-Induced Growth Inhibitor in Mammary Gland.

H. Huynh, C. Y. Ng, C. K. Ong, K. B. Lim, and T. W. M. Chan (2001)
Endocrinology 142, 3607-3615
 |  Abstract »  |  Full Text »  |  PDF »

The Retinoblastoma Gene Regulates Somatic Growth during Mouse Development.

A. Yu. Nikitin, B. Shan, A. Flesken-Nikitin, K.-H. Chang, and W.-H. Lee (2001)
Cancer Res. 61, 3110-3118
 |  Abstract »  |  Full Text »

RB2/p130 Gene-enhanced Expression Down-Regulates Vascular Endothelial Growth Factor Expression and Inhibits Angiogenesis in Vivo.

P. P. Claudio, P. Stiegler, C. M. Howard, C. Bellan, C. Minimo, G. M. Tosi, J. Rak, A. Kovatich, Paola De Fazio, P. Micheli, et al. (2001)
Cancer Res. 61, 462-468
 |  Abstract »  |  Full Text »

The Rb/E2F pathway: expanding roles and emerging paradigms.

J. W. Harbour and D. C. Dean (2000)
Genes & Dev. 14, 2393-2409
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Cloning and Characterization of a Novel Kruppel-associated Box Family Transcriptional Repressor That Interacts with the Retinoblastoma Gene Product, RB.

S. X. Skapek, D. Jansen, T.-F. Wei, T. McDermott, W. Huang, E. N. Olson, and E. Y.-H. P. Lee (2000)
J. Biol. Chem. 275, 7212-7223
 |  Abstract »  |  Full Text »  |  PDF »

Mutations in the Retinoblastoma-related Gene RB2/p130 in Lung Tumors and Suppression of Tumor Growth in Vivo by Retrovirus-mediated Gene Transfer.

P. P. Claudio, C. M. Howard, C. Pacilio, C. Cinti, G. Romano, C. Minimo, N. M. Maraldi, J. D. Minna, L. Gelbert, L. Leoncini, et al. (2000)
Cancer Res. 60, 372-382
 |  Abstract »  |  Full Text »

Transfection of an Inducible p16/CDKN2A Construct Mediates Reversible Growth Inhibition and G1 Arrest in the AtT20 Pituitary Tumor Cell Line.

S. J. Frost, D. J. Simpson, R. N. Clayton, and W. E. Farrell (1999)
Mol. Endocrinol. 13, 1801-1810
 |  Abstract »  |  Full Text »

Expression of OVCA1, a Candidate Tumor Suppressor, Is Reduced in Tumors and Inhibits Growth of Ovarian Cancer Cells.

W. Bruening, A. H. Prowse, D. C. Schultz, M. Holgado-Madruga, A. Wong, and A. K. Godwin (1999)
Cancer Res. 59, 4973-4983
 |  Abstract »  |  Full Text »  |  PDF »

Simian Virus 40 Large T Antigen J Domain and Rb-Binding Motif Are Sufficient To Block Apoptosis Induced by Growth Factor Withdrawal in a Neural Stem Cell Line.

A. Slinskey, D. Barnes, and J. M. Pipas (1999)
J. Virol. 73, 6791-6799
 |  Abstract »  |  Full Text »

Bdp, a New Member of a Family of DNA-binding Proteins, Associates with the Retinoblastoma Gene Product.

S.-i. Numata, P. P. Claudio, C. Dean, A. Giordano, and C. M. Croce (1999)
Cancer Res. 59, 3741-3747
 |  Abstract »  |  Full Text »  |  PDF »

Retinoblastoma Protein Expression Leads to Reduced Oct-1 DNA Binding Activity and Enhances Interleukin-8 Expression.

H. Zhang, A. T. Shepherd, D. D. Eason, S. Wei, J. I. Diaz, J. Y. Djeu, G. D. Wu, and G. Blanck (1999)
Cell Growth Differ. 10, 457-465
 |  Abstract »  |  Full Text »

Reversible Tumorigenesis Induced by Deficiency of Vasodilator-Stimulated Phosphoprotein.

K. Liu, L. Li, P. E. Nisson, C. Gruber, J. Jessee, and S. N. Cohen (1999)
Mol. Cell. Biol. 19, 3696-3703
 |  Abstract »  |  Full Text »  |  PDF »

RB-mediated suppression of spontaneous multiple neuroendocrine neoplasia and lung metastases in Rb+/- mice.

A. Yu. Nikitin, M. I. Juarez-Perez, S. Li, L. Huang, and W.-H. Lee (1999)
PNAS 96, 3916-3921
 |  Abstract »  |  Full Text »  |  PDF »

Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth.

W. R. Sellers, B. G. Novitch, S. Miyake, A. Heith, G. A. Otterson, F. J. Kaye, A. B. Lassar, and W. G. Kaelin Jr. (1998)
Genes & Dev. 12, 95-106
 |  Abstract »  |  Full Text »

Adenoviral Constructs Encoding Phosphorylation-Competent Full-length and Truncated Forms of the Human Retinoblastoma Protein Inhibit Myocyte Proliferation and Neointima Formation.

R. C. Smith, K. N. Wills, D. Antelman, H. Perlman, L. N. Truong, K. Krasinski, and K. Walsh (1997)
Circulation 96, 1899-1905
 |  Abstract »  |  Full Text »

Altered Expression of the Retinoblastoma Tumor-Suppressor Gene in Leukemic Cell Lines Inhibits Induction of Differentiation But Not G1-Accumulation.

G. Bergh, M. Ehinger, T. Olofsson, B. Baldetorp, E. Johnsson, H. Brycke, G. Lindgren, I. Olsson, and U. Gullberg (1997)
Blood 89, 2938-2950
 |  Abstract »  |  Full Text »  |  PDF »

Two contact regions between Stat1 and CBP/p300 in interferon gamma  signaling.

J. J. Zhang, U. Vinkemeier, W. Gu, D. Chakravarti, C. M. Horvath, and J. E. Darnell Jr. (1996)
PNAS 93, 15092-15096
 |  Abstract »  |  Full Text »  |  PDF »

Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs..

P L Chen, D J Riley, Y Chen, and W H Lee (1996)
Genes & Dev. 10, 2794-2804
 |  Abstract »  |  PDF »

Shared role of the pRB-related p130 and p107 proteins in limb development..

D Cobrinik, M H Lee, G Hannon, G Mulligan, R T Bronson, N Dyson, E Harlow, D Beach, R A Weinberg, and T Jacks (1996)
Genes & Dev. 10, 1633-1644
 |  Abstract »  |  PDF »

MCC, a Cytoplasmic Protein That Blocks Cell Cycle Progression from the G(0)/G(1) to S Phase.

A. Matsumine, T. Senda, G.-H. Baeg, B. C. Roy, Y. Nakamura, M. Noda, K. Toyoshima, and T. Akiyama (1996)
J. Biol. Chem. 271, 10341-10346
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-1 Induces Growth Arrest by Hypophosphorylation of the Retinoblastoma Susceptibility Gene Product RB.

S. Muthukkumar, S. F. Sells, S. A. Crist, and V. M. Rangnekar (1996)
J. Biol. Chem. 271, 5733-5740
 |  Abstract »  |  Full Text »  |  PDF »

Dual Retinoblastoma-binding Proteins with Properties Related to a Negative Regulator of Ras in Yeast.

Y.-W. Qian and E. Y.-H. P. Lee (1995)
J. Biol. Chem. 270, 25507-25513
 |  Abstract »  |  Full Text »  |  PDF »

Detection of a Novel Cell Cycle-regulated Kinase Activity That Associates with the Amino Terminus of the Retinoblastoma Protein in G[IMAGE]/M Phases.

J. M. Sterner, Y. Murata, H. G. Kim, S. B. Kennett, D. J. Templeton, and J. M. Horowitz (1995)
J. Biol. Chem. 270, 9281-9288
 |  Abstract »  |  Full Text »  |  PDF »

Binding of an Interferon-inducible Protein (p202) to the Retinoblastoma Protein.

D. Choubey and P. Lengyel (1995)
J. Biol. Chem. 270, 6134-6140
 |  Abstract »  |  Full Text »  |  PDF »

In vitro p53 and/or Rb antisense oligonucleotide treatment in association with growth factors induces the proliferation of peripheral hematopoietic progenitors.

T Mahdi, A Brizard, C Millet, P Dore, J Tanzer, and A Kitzis (1995)
J. Cell Sci. 108, 1287-1293
 |  Abstract »  |  PDF »

Disruption of retinoblastoma protein function by coexpression of its C pocket fragment..

P J Welch and J Y Wang (1995)
Genes & Dev. 9, 31-46
 |  Abstract »  |  PDF »

Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation..

E Y Lee, N Hu, S S Yuan, L A Cox, A Bradley, W H Lee, and K Herrup (1994)
Genes & Dev. 8, 2008-2021
 |  Abstract »  |  PDF »

Reversal of terminal differentiation mediated by p107 in Rb-/- muscle cells.

J. Schneider, W Gu, L Zhu, V Mahdavi, and B Nadal-Ginard (1994)
Science 264, 1467-1471
 |  Abstract »  |  PDF »

The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein..

A Iavarone, P Garg, A Lasorella, J Hsu, and M A Israel (1994)
Genes & Dev. 8, 1270-1284
 |  Abstract »  |  PDF »

Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor..

R Eckner, M E Ewen, D Newsome, M Gerdes, J A DeCaprio, J B Lawrence, and D M Livingston (1994)
Genes & Dev. 8, 869-884
 |  Abstract »  |  PDF »

The Molecular Basis of Leukemia.

M. J. Cline (1994)
N. Engl. J. Med. 330, 328-336
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Growth Suppression by Members of the Retinoblastoma Protein Family.

L. Zhu, G.H. Enders, C.-L. Wu, M.A. Starz, K.H. Moberg, J.A. Lees, N. Dyson, and E. Harlow (1994)
Cold Spring Harb Symp Quant Biol 59, 75-84
 |  Abstract »  |  PDF »

The Corral Hypothesis: A Novel Regulatory Mode for Retinoblastoma Protein Function.

W.-H. Lee, Y. Xu, F. Hong, T. Durfee, M.A. Mancini, Y.-C. Ueng, P.-L. Chen, and D. Riley (1994)
Cold Spring Harb Symp Quant Biol 59, 97-107
 |  Abstract »  |  PDF »

WT1-mediated growth suppression of Wilms tumor cells expressing a WT1 splicing variant.

D. Haber, S Park, S Maheswaran, C Englert, G. Re, D. Hazen-Martin, D. Sens, and A. Garvin (1993)
Science 262, 2057-2059
 |  Abstract »  |  PDF »

A Drosophila G1-specific cyclin E homolog exhibits different modes of expression during embryogenesis.

H. E. Richardson, L. V. O'Keefe, S. I. Reed, and R. Saint (1993)
Development 119, 673-690
 |  Abstract »  |  PDF »

Expression of a retinoblastoma transgene results in dwarf mice..

Y J Bignon, Y Chen, C Y Chang, D J Riley, J J Windle, P L Mellon, and W H Lee (1993)
Genes & Dev. 7, 1654-1662
 |  Abstract »  |  PDF »

Genetics of Tumors of the Head and Neck.

A. Knudson Jr (1993)
Arch Otolaryngol Head Neck Surg 119, 735-737
 |  Abstract »  |  PDF »

The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit..

T Durfee, K Becherer, P L Chen, S H Yeh, Y Yang, A E Kilburn, W H Lee, and S J Elledge (1993)
Genes & Dev. 7, 555-569
 |  Abstract »  |  PDF »

E2F: a link between the Rb tumor suppressor protein and viral oncoproteins.

Nevins JR (1992)
Science 258, 424-429
 |  Abstract »  |  PDF »

Identification of a growth suppression domain within the retinoblastoma gene product..

X Q Qin, T Chittenden, D M Livingston, and W G Kaelin (1992)
Genes & Dev. 6, 953-964
 |  Abstract »  |  PDF »

Immortalization of conditionally transformed chicken cells: loss of normal p53 expression is an early step that is independent of cell transformation..

E Ulrich, G Boehmelt, A Bird, and H Beug (1992)
Genes & Dev. 6, 876-887
 |  Abstract »  |  PDF »

The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F..

S W Hiebert, S P Chellappan, J M Horowitz, and J R Nevins (1992)
Genes & Dev. 6, 177-185
 |  Abstract »  |  PDF »

Tumor suppressor genes.

R. Weinberg (1991)
Science 254, 1138-1146
 |  Abstract »  |  PDF »

c-myc and pRB: Role in TGF-{beta}1 Inhibition of Keratinocyte Proliferation.

C.S. Murphy, J.A. Pietenpol, K. Munger, P.M. Howley, and H.L. Moses (1991)
Cold Spring Harb Symp Quant Biol 56, 129-135
 |  Abstract »  |  PDF »

RB Associates with an E2F-like, Sequence-specific DNA-binding Protein.

T. Chittenden, D.M. Livingston, and W.G. Kaelin Jr. (1991)
Cold Spring Harb Symp Quant Biol 56, 187-195
 |  Abstract »  |  PDF »

Modulation of Retinoblastoma Protein Activity during the Cell Cycle.

S. Mittnacht, P.W. Hinds, S.F. Dowdy, and R.A. Weinberg (1991)
Cold Spring Harb Symp Quant Biol 56, 197-209
 |  Abstract »  |  PDF »

Genetic mechanisms of tumor suppression by the human p53 gene.

P. Chen, Y. Chen, R Bookstein, and W. Lee (1990)
Science 250, 1576-1580
 |  Abstract »  |  PDF »

Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts.

G. Stein, M Beeson, and L Gordon (1990)
Science 249, 666-669
 |  Abstract »  |  PDF »

Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene.

R Bookstein, J. Shew, P. Chen, P Scully, and W. Lee (1990)
Science 247, 712-715
 |  Abstract »  |  PDF »

Identifying tumor suppressor genes in human colorectal cancer.

E. Stanbridge (1990)
Science 247, 12-13
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Mechanisms Regulating Cell Number and Type in the Mammalian Central Nervous System.

R. McKay, N. Valtz, M. Cunningham, and T. Hayes (1990)
Cold Spring Harb Symp Quant Biol 55, 291-301
 |  Abstract »  |  PDF »

p53: oncogene or anti-oncogene?.

D P Lane and S Benchimol (1990)
Genes & Dev. 4, 1-8
 |  PDF »

Tumor suppressor genes: the puzzle and the promise.

R Sager (1989)
Science 246, 1406-1412
 |  Abstract »  |  PDF »

G1 events and regulation of cell proliferation.

A. Pardee (1989)
Science 246, 603-608
 |  Abstract »  |  PDF »

Progress toward human gene therapy.

T Friedmann (1989)
Science 244, 1275-1281
 |  Abstract »  |  PDF »

A Novel Cellular Protein (MTBP) Binds to MDM2 and Induces a G1 Arrest That Is Suppressed by MDM2.

M. T. Boyd, N. Vlatkovic, and D. S. Haines (2000)
J. Biol. Chem. 275, 31883-31890
 |  Abstract »  |  Full Text »  |  PDF »

Antisense RNA-mediated Deficiency of the Calpain Protease, nCL-4, in NIH3T3 Cells Is Associated with Neoplastic Transformation and Tumorigenesis.

K. Liu, L. Li, and S. N. Cohen (2000)
J. Biol. Chem. 275, 31093-31098
 |  Abstract »  |  Full Text »  |  PDF »

Neoplastic Transformation and Tumorigenesis Associated with Sam68 Protein Deficiency in Cultured Murine Fibroblasts.

K. Liu, L. Li, P. E. Nisson, C. Gruber, J. Jessee, and S. N. Cohen (2000)
J. Biol. Chem. 275, 40195-40201
 |  Abstract »  |  Full Text »  |  PDF »

Collective Inhibition of pRB Family Proteins by Phosphorylation in Cells with p16INK4a Loss or Cyclin E Overexpression.

S. Ashizawa, H. Nishizawa, M. Yamada, H. Higashi, T. Kondo, H. Ozawa, A. Kakita, and M. Hatakeyama (2001)
J. Biol. Chem. 276, 11362-11370
 |  Abstract »  |  Full Text »  |  PDF »

ANX7, a candidate tumor suppressor gene for prostate cancer.

M. Srivastava, L. Bubendorf, V. Srikantan, L. Fossom, L. Nolan, M. Glasman, X. Leighton, W. Fehrle, S. Pittaluga, M. Raffeld, et al. (2001)
PNAS 98, 4575-4580
 |  Abstract »  |  Full Text »  |  PDF »

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