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Science 16 December 1988:
Vol. 242. no. 4885, pp. 1557 - 1559
DOI: 10.1126/science.3201246
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Articles
Science, Vol 242, Issue 4885, 1557-1559
Copyright © 1988 by American Association for the Advancement of Science
Human T cell leukemia viruses use a receptor determined by human chromosome 17
MA Sommerfelt,
BP Williams,
PR Clapham,
E Solomon,
PN Goodfellow,
and
RA Weiss
Chester Beatty Laboratories, Institute of Cancer Research, London, U.K.
Human T cell leukemia viruses (HTLV-I and HTLV-II) can infect many cell types in vitro. HTLV-I and HTLV-II use the same cell surface receptor, as shown by interference with syncytium formation and with infection by vesicular stomatitis virus (VSV) pseudotypes bearing the HTLV envelope glycoproteins. Human-mouse somatic cell hybrids were used to determine which human chromosome was required to confer susceptibility to VSV(HTLV) infection. The only human chromosome common to all susceptible cell hybrids was chromosome 17, and the receptor gene was localized to 17cen-qter. Antibodies to surface antigens known to be determined by genes on 17q did not block the HTLV receptor.
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