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Science 16 December 1988:
Vol. 242. no. 4885, pp. 1528 - 1534
DOI: 10.1126/science.3201241
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Articles

Science, Vol 242, Issue 4885, 1528-1534
Copyright © 1988 by American Association for the Advancement of Science

articles

Novel regulators of bone formation: molecular clones and activities

JM Wozney, V Rosen, AJ Celeste, LM Mitsock, MJ Whitters, RW Kriz, RM Hewick, and EA Wang

Tissue Growth and Repair Program, Genetics Institute, Inc., Cambridge, MA 02140.

Protein extracts derived from bone can initiate the process that begins with cartilage formation and ends in de novo bone formation. The critical components of this extract, termed bone morphogenetic protein (BMP), that direct cartilage and bone formation as well as the constitutive elements supplied by the animal during this process have long remained unclear. Amino acid sequence has been derived from a highly purified preparation of BMP from bovine bone. Now, human complementary DNA clones corresponding to three polypeptides present in this BMP preparation have been isolated, and expression of the recombinant human proteins have been obtained. Each of the three (BMP-1, BMP-2A, and BMP-3) appears to be independently capable of inducing the formation of cartilage in vivo. Two of the encoded proteins (BMP-2A and BMP-3) are new members of the TGF-beta supergene family, while the third, BMP-1, appears to be a novel regulatory molecule.


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   Abstract »    Full Text »    PDF »
Inhibitor of DNA Binding/Differentiation Helix-Loop-Helix Proteins Mediate Bone Morphogenetic Protein-induced Osteoblast Differentiation of Mesenchymal Stem Cells.
Y. Peng, Q. Kang, Q. Luo, W. Jiang, W. Si, B. A. Liu, H. H. Luu, J. K. Park, X. Li, J. Luo, et al. (2004)
J. Biol. Chem. 279, 32941-32949
   Abstract »    Full Text »    PDF »
An Evolutionary and Molecular Analysis of Bmp2 Expression.
K. L. Abrams, J. Xu, C. Nativelle-Serpentini, S. Dabirshahsahebi, and M. B. Rogers (2004)
J. Biol. Chem. 279, 15916-15928
   Abstract »    Full Text »    PDF »
Smurf1 Inhibits Osteoblast Differentiation and Bone Formation in Vitro and in Vivo.
M. Zhao, M. Qiao, S. E. Harris, B. O. Oyajobi, G. R. Mundy, and D. Chen (2004)
J. Biol. Chem. 279, 12854-12859
   Abstract »    Full Text »    PDF »
Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton.
F. Long, U.-i. Chung, S. Ohba, J. McMahon, H. M. Kronenberg, and A. P. McMahon (2004)
Development 131, 1309-1318
   Abstract »    Full Text »    PDF »
Bone Morphogenetic Protein-2 Stimulates Angiogenesis in Developing Tumors.
E. M. Langenfeld and J. Langenfeld (2004)
Mol. Cancer Res. 2, 141-149
   Abstract »    Full Text »    PDF »
Increased syndecan expression following myocardial infarction indicates a role in cardiac remodeling.
A. V. Finsen, P. R. Woldbaek, J. Li, J. Wu, T. Lyberg, T. Tonnessen, and G. Christensen (2004)
Physiol Genomics 16, 301-308
   Abstract »    Full Text »    PDF »
The Bone Morphogenetic Protein System In Mammalian Reproduction.
S. Shimasaki, R. K. Moore, F. Otsuka, and G. F. Erickson (2004)
Endocr. Rev. 25, 72-101
   Abstract »    Full Text »    PDF »
Virus-Host Cell Interactions during Hepatitis C Virus RNA Replication: Impact of Polyprotein Expression on the Cellular Transcriptome and Cell Cycle Association with Viral RNA Synthesis.
F. Scholle, K. Li, F. Bodola, M. Ikeda, B. A. Luxon, and S. M. Lemon (2004)
J. Virol. 78, 1513-1524
   Abstract »    Full Text »    PDF »
Bone Morphogenetic Protein-1/Tolloid-like Proteinases Process Dentin Matrix Protein-1.
B. M. Steiglitz, M. Ayala, K. Narayanan, A. George, and D. S. Greenspan (2004)
J. Biol. Chem. 279, 980-986
   Abstract »    Full Text »    PDF »
Decreased Expression of Bone Morphogenetic Protein (BMP) Receptor Type II Correlates with Insensitivity to BMP-6 in Human Renal Cell Carcinoma Cells.
I. Y. Kim, D.-H. Lee, D. K. Lee, B. C. Kim, H. T. Kim, F. S. Leach, W. M. Linehan, R. A. Morton, and S. J. Kim (2003)
Clin. Cancer Res. 9, 6046-6051
   Abstract »    Full Text »    PDF »
Brief Bone Morphogenetic Protein 2 Treatment of Glucocorticoid-inhibited MC3T3-E1 Osteoblasts Rescues Commitment-associated Cell Cycle and Mineralization without Alteration of Runx2.
C. A. Luppen, N. Leclerc, T. Noh, A. Barski, A. Khokhar, A. L. Boskey, E. Smith, and B. Frenkel (2003)
J. Biol. Chem. 278, 44995-45003
   Abstract »    Full Text »    PDF »
Sulfated Polysaccharides Enhance the Biological Activities of Bone Morphogenetic Proteins.
T. Takada, T. Katagiri, M. Ifuku, N. Morimura, M. Kobayashi, K. Hasegawa, A. Ogamo, and R. Kamijo (2003)
J. Biol. Chem. 278, 43229-43235
   Abstract »    Full Text »    PDF »
The mature bone morphogenetic protein-2 is aberrantly expressed in non-small cell lung carcinomas and stimulates tumor growth of A549 cells.
E. M. Langenfeld, S. E. Calvano, F. Abou-Nukta, S. F. Lowry, P. Amenta, and J. Langenfeld (2003)
Carcinogenesis 24, 1445-1454
   Abstract »    Full Text »    PDF »
A Single Percutaneous Injection of Recombinant Human Bone Morphogenetic Protein-2 Accelerates Fracture Repair.
T. A. Einhorn, R. J Majeska, A. Mohaideen, E. M. Kagel, M. L. Bouxsein, T. J. Turek, and J. M. Wozney (2003)
J. Bone Joint Surg. Am. 85, 1425-1435
   Abstract »    Full Text »    PDF »
Osteogenic Activity of the Fourteen Types of Human Bone Morphogenetic Proteins (BMPs).
H. Cheng, W. Jiang, F. M. Phillips, R. C. Haydon, Y. Peng, L. Zhou, H. H. Luu, N. An, B. Breyer, P. Vanichakarn, et al. (2003)
J. Bone Joint Surg. Am. 85, 1544-1552
   Abstract »    Full Text »    PDF »
Marshall R. Urist: A Renaissance Scientist and Orthopaedic Surgeon.
A. H. Reddi (2003)
J. Bone Joint Surg. Am. 85, 3-7
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Signal Transduction of Bone Morphogenetic Proteins in Osteoblast Differentiation.
P. t. Dijke, J. Fu, P. Schaap, and B. A.J. Roelen (2003)
J. Bone Joint Surg. Am. 85, 34-38
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Clinical Applications of Recombinant Human BMPs: Early Experience and Future Development.
T. A. Einhorn (2003)
J. Bone Joint Surg. Am. 85, 82-88
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Use of Bmp1/Tll1 Doubly Homozygous Null Mice and Proteomics To Identify and Validate In Vivo Substrates of Bone Morphogenetic Protein 1/Tolloid-Like Metalloproteinases.
W. N. Pappano, B. M. Steiglitz, I. C. Scott, D. R. Keene, and D. S. Greenspan (2003)
Mol. Cell. Biol. 23, 4428-4438
   Abstract »    Full Text »    PDF »
Effects of intravascular cryotherapy on vessel wall repair in a balloon-injured rabbit iliac artery model.
A. N Cheema, N. Nili, C. W Li, H. A Whittingham, J. Linde, R. J van Suylen, M. R Eskandarian, A. P Wong, B. Qiang, J.-F. Tanguay, et al. (2003)
Cardiovasc Res 59, 222-233
   Abstract »    Full Text »    PDF »
Regulation of Myostatin in Vivo by Growth and Differentiation Factor-Associated Serum Protein-1: A Novel Protein with Protease Inhibitor and Follistatin Domains.
J. J. Hill, Y. Qiu, R. M. Hewick, and N. M. Wolfman (2003)
Mol. Endocrinol. 17, 1144-1154
   Abstract »    Full Text »    PDF »


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