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Science 9 December 1988:
Vol. 242. no. 4884, pp. 1444 - 1446
DOI: 10.1126/science.3201232
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Articles

Science, Vol 242, Issue 4884, 1444-1446
Copyright © 1988 by American Association for the Advancement of Science

articles

Astrocytes synthesize angiotensinogen in brain

RL Stornetta, CL Hawelu-Johnson, PG Guyenet, and KR Lynch

Department of Pharmacology, University of Virginia School of Medicine, Charlottesville 22908.

Cell types associated with angiotensinogen mRNA in rat brain were identified in individual brain sections by in situ hybridization with tritiated RNA probes or with a sulfur-35--labeled oligonucleotide combined with immunocytochemical detection of either glial fibrillary acidic protein (GFAP) for astrocytes or microtubule-associated protein (MAP-2) for neurons. Autoradiography revealed silver grains clustered primarily over GFAP-reactive soma and processes; most grain clusters were not associated with MAP-2--reactive cells. These results demonstrate that, in contrast to other known neuropeptide precursors, angiotensinogen is synthesized by glia.


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