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Science 9 December 1988:
Vol. 242. no. 4884, pp. 1433 - 1437
DOI: 10.1126/science.3144040
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Articles
Science, Vol 242, Issue 4884, 1433-1437
Copyright © 1988 by American Association for the Advancement of Science
Newly identified brain potassium channels gated by the guanine nucleotide binding protein Go
AM VanDongen,
J Codina,
J Olate,
R Mattera,
R Joho,
L Birnbaumer,
and
AM Brown
Department of Physiology and Molecular Biophysics, Baylor College of Medicine, Houston, TX 77030.
Potassium channels in neurons are linked by guanine nucleotide binding (G) proteins to numerous neurotransmitter receptors. The ability of Go, the predominant G protein in the brain, to stimulate potassium channels was tested in cell-free membrane patches of hippocampal pyramidal neurons. Four distinct types of potassium channels, which were otherwise quiescent, were activated by both isolated brain G0 and recombinant Go alpha. Hence brain Go can couple diverse brain potassium channels to neurotransmitter receptors.
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