Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 9 December 1988:
Vol. 242. no. 4884, pp. 1430 - 1433
DOI: 10.1126/science.2974179
Prev | Table of Contents | Next

Articles

Science, Vol 242, Issue 4884, 1430-1433
Copyright © 1988 by American Association for the Advancement of Science

articles

Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA

JP Hoeffler, TE Meyer, Y Yun, JL Jameson, and JF Habener

Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Boston.

Cyclic AMP (cAMP) is an intracellular second messenger that activates transcription of many cellular genes. A palindromic consensus DNA sequence, TGACGTCA, functions as a cAMP-responsive transcriptional enhancer (CRE). The CRE binds a cellular protein of 38 kD in placental JEG-3 cells. A placental lambda gt11 library was screened for expression of specific CRE-binding proteins with the CRE sequence as a radioactive probe. A cDNA encoding a protein of 326 amino acids with the binding properties of a specific CRE-binding protein (CREB) was isolated. The protein contains a COOH-terminal basic region adjacent to a sequence similar to the "leucine zipper" sequence believed to be involved in DNA binding and in protein-protein contacts in several other DNA-associated transcriptional proteins including the products of the c-myc, c-fos, and c-jun oncogenes and GCN4. The CREB protein also contains an NH2-terminal acidic region proposed to be a potential transcriptional activation domain. The putative DNA-binding domain of CREB is structurally similar to the corresponding domains in the phorbol ester-responsive c-jun protein and the yeast transcription factor GCN4.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cyclin-Dependent Kinase 3-Mediated Activating Transcription Factor 1 Phosphorylation Enhances Cell Transformation.
D. Zheng, Y.-Y. Cho, A. T.Y. Lau, J. Zhang, W.-Y. Ma, A. M. Bode, and Z. Dong (2008)
Cancer Res. 68, 7650-7660
   Abstract »    Full Text »    PDF »
A Composite Element that Binds Basic Helix Loop Helix and Basic Leucine Zipper Transcription Factors Is Important for Gonadotropin-Releasing Hormone Regulation of the Follicle-Stimulating Hormone {beta} Gene.
N. A. Ciccone, C. T. Lacza, M. Y. Hou, S. J. Gregory, K.-Y. Kam, S. Xu, and U. B. Kaiser (2008)
Mol. Endocrinol. 22, 1908-1923
   Abstract »    Full Text »    PDF »
CREB has a context-dependent role in activity-regulated transcription and maintains neuronal cholesterol homeostasis.
T. Lemberger, J. R. Parkitna, M. Chai, G. Schutz, and D. Engblom (2008)
FASEB J 22, 2872-2879
   Abstract »    Full Text »    PDF »
DNA Binding and Phosphorylation Induce Conformational Alterations in the Kinase-inducible Domain of CREB: IMPLICATIONS FOR THE MECHANISM OF TRANSCRIPTION FUNCTION.
N. Sharma, D. I. Lopez, and J. K. Nyborg (2007)
J. Biol. Chem. 282, 19872-19883
   Abstract »    Full Text »    PDF »
Cyclic adenosine monophosphate is a key component of regulatory T cell mediated suppression.
T. Bopp, C. Becker, M. Klein, S. Klein-Hessling, A. Palmetshofer, E. Serfling, V. Heib, M. Becker, J. Kubach, S. Schmitt, et al. (2007)
J. Exp. Med. 204, 1303-1310
   Abstract »    Full Text »    PDF »
Cardiomyocyte-specific inactivation of transcription factor CREB in mice.
M. Matus, G. Lewin, F. Stumpel, I. B. Buchwalow, M. D. Schneider, G. Schutz, W. Schmitz, and F. U. Muller (2007)
FASEB J 21, 1884-1892
   Abstract »    Full Text »    PDF »
Transcriptional Regulation of Cyclin D2 by the PKA Pathway and Inducible cAMP Early Repressor in Granulosa Cells.
L. C. Muniz, G. Yehia, E. Memin, P. V.A.L. Ratnakar, and C. A. Molina (2006)
Biol Reprod 75, 279-288
   Abstract »    Full Text »    PDF »
Switching of NR5A Proteins Associated with the Inhibin {alpha}-Subunit Gene Promoter after Activation of the Gene in Granulosa Cells.
J. Weck and K. E. Mayo (2006)
Mol. Endocrinol. 20, 1090-1103
   Abstract »    Full Text »    PDF »
The 5'-AT-rich half-site of Maf recognition element: a functional target for bZIP transcription factor Maf.
T. Yoshida, T. Ohkumo, S. Ishibashi, and K. Yasuda (2005)
Nucleic Acids Res. 33, 3465-3478
   Abstract »    Full Text »    PDF »
Small Interference RNA-mediated Gene Silencing of Human Biliverdin Reductase, but Not That of Heme Oxygenase-1, Attenuates Arsenite-mediated Induction of the Oxygenase and Increases Apoptosis in 293A Kidney Cells.
T. Miralem, Z. Hu, M. D. Torno, K. M. Lelli, and M. D. Maines (2005)
J. Biol. Chem. 280, 17084-17092
   Abstract »    Full Text »    PDF »
Repression of the Inhibin {alpha}-Subunit Gene by the Transcription Factor CCAAT/Enhancer-Binding Protein-{beta}.
A. D. Burkart, A. Mukherjee, E. Sterneck, P. F. Johnson, and K. E. Mayo (2005)
Endocrinology 146, 1909-1921
   Abstract »    Full Text »    PDF »
Identification of human myometrial target genes of the c-Jun NH2-terminal kinase (JNK) pathway: the role of activating transcription factor 2 (ATF2) and a novel spliced isoform ATF2-small.
J. Bailey and G N. Europe-Finner (2005)
J. Mol. Endocrinol. 34, 19-35
   Abstract »    Full Text »    PDF »
Regulation of interleukin-12 gene expression and its anti-tumor activities by prostaglandin E2 derived from mammary carcinomas.
M. Mitsuhashi, J. Liu, S. Cao, X. Shi, and X. Ma (2004)
J. Leukoc. Biol. 76, 322-332
   Abstract »    Full Text »    PDF »
Interleukin-10 Induced Activating Transcription Factor 3 Transcriptional Suppression of Matrix Metalloproteinase-2 Gene Expression in Human Prostate CPTX-1532 Cells.
M. E. Stearns, G. Kim, F. Garcia, and M. Wang (2004)
Mol. Cancer Res. 2, 403-416
   Abstract »    Full Text »    PDF »
Biliverdin Reductase, a Novel Regulator for Induction of Activating Transcription Factor-2 and Heme Oxygenase-1.
A. Kravets, Z. Hu, T. Miralem, M. D. Torno, and M. D. Maines (2004)
J. Biol. Chem. 279, 19916-19923
   Abstract »    Full Text »    PDF »
Endocrine Disruption by Cadmium, a Common Environmental Toxicant with Paradoxical Effects on Reproduction.
M. C. Henson and P. J. Chedrese (2004)
Experimental Biology and Medicine 229, 383-392
   Abstract »    Full Text »    PDF »
A Novel Retinoic Acid-Responsive Element Regulates Retinoic Acid-Induced BLR1 Expression.
J. Wang and A. Yen (2004)
Mol. Cell. Biol. 24, 2423-2443
   Abstract »    Full Text »    PDF »
Cadmium Stimulates Transcription of the Cytochrome P450 Side Chain Cleavage Gene in Genetically Modified Stable Porcine Granulosa Cells.
A. D. Smida, X. P. Valderrama, M. C. Agostini, M. A. Furlan, and J. Chedrese (2004)
Biol Reprod 70, 25-31
   Abstract »    Full Text »    PDF »
Deacetylase Activity Is Required for cAMP Activation of a Subset of CREB Target Genes.
D. M. Fass, J. E. F. Butler, and R. H. Goodman (2003)
J. Biol. Chem. 278, 43014-43019
   Abstract »    Full Text »    PDF »
Protein Kinase B/Akt Binds and Phosphorylates PED/PEA-15, Stabilizing Its Antiapoptotic Action.
A. Trencia, A. Perfetti, A. Cassese, G. Vigliotta, C. Miele, F. Oriente, S. Santopietro, F. Giacco, G. Condorelli, P. Formisano, et al. (2003)
Mol. Cell. Biol. 23, 4511-4521
   Abstract »    Full Text »    PDF »
The Activation of c-Jun NH2-terminal Kinase (JNK) by DNA-damaging Agents Serves to Promote Drug Resistance via Activating Transcription Factor 2 (ATF2)-dependent Enhanced DNA Repair.
J. Hayakawa, C. Depatie, M. Ohmichi, and D. Mercola (2003)
J. Biol. Chem. 278, 20582-20592
   Abstract »    Full Text »    PDF »
Transcriptional Regulation of Heme Oxygenase-1 Gene Expression by MAP Kinases of the JNK and p38 Pathways in Primary Cultures of Rat Hepatocytes.
T. Kietzmann, A. Samoylenko, and S. Immenschuh (2003)
J. Biol. Chem. 278, 17927-17936
   Abstract »    Full Text »    PDF »
Transcriptional Regulation of the MHC Class II Trans-Activator (CIITA) Promoter III: Identification of a Novel Regulatory Region in the 5'-Untranslated Region and an Important Role for cAMP-Responsive Element Binding Protein 1 and Activating Transcription Factor-1 in CIITA-Promoter III Transcriptional Activation in B Lymphocytes.
N. van der Stoep, E. Quinten, and P. J. van den Elsen (2002)
J. Immunol. 169, 5061-5071
   Abstract »    Full Text »    PDF »
Classification of Human B-ZIP Proteins Based on Dimerization Properties.
C. Vinson, M. Myakishev, A. Acharya, A. A. Mir, J. R. Moll, and M. Bonovich (2002)
Mol. Cell. Biol. 22, 6321-6335
   Full Text »    PDF »
Inducible and Brain Region-Specific CREB Transgenic Mice.
N. Sakai, J. Thome, S. S. Newton, J. Chen, M. B. Kelz, C. Steffen, E. J. Nestler, and R. S. Duman (2002)
Mol. Pharmacol. 61, 1453-1464
   Abstract »    Full Text »    PDF »
Salt-inducible Kinase Represses cAMP-dependent Protein Kinase-mediated Activation of Human Cholesterol Side Chain Cleavage Cytochrome P450 Promoter through the CREB Basic Leucine Zipper Domain.
J. Doi, H. Takemori, X.-z. Lin, N. Horike, Y. Katoh, and M. Okamoto (2002)
J. Biol. Chem. 277, 15629-15637
   Abstract »    Full Text »    PDF »
Human Biliverdin Reductase Is a Leucine Zipper-like DNA-binding Protein and Functions in Transcriptional Activation of Heme Oxygenase-1 by Oxidative Stress.
Z. Ahmad, M. Salim, and M. D. Maines (2002)
J. Biol. Chem. 277, 9226-9232
   Abstract »    Full Text »    PDF »
Regulation of Steroidogenesis and the Steroidogenic Acute Regulatory Protein by a Member of the cAMP Response-Element Binding Protein Family.
P. R. Manna, M. T. Dyson, D. W. Eubank, B. J. Clark, E. Lalli, P. Sassone-Corsi, A. J. Zeleznik, and D. M. Stocco (2002)
Mol. Endocrinol. 16, 184-199
   Abstract »    Full Text »    PDF »
Prostaglandin E2-Mediated Activation of HIV-1 Long Terminal Repeat Transcription in Human T Cells Necessitates CCAAT/Enhancer Binding Protein (C/EBP) Binding Sites in Addition to Cooperative Interactions Between C/EBP{beta} and Cyclic Adenosine 5'-Monophosphate Response Element Binding Protein.
N. Dumais, S. Bounou, M. Olivier, and M. J. Tremblay (2002)
J. Immunol. 168, 274-282
   Abstract »    Full Text »    PDF »
Activation and inactivation of cAMP-response element-mediated gene transcription in cardiac myocytes.
F. U Muller, P. Boknik, J. Knapp, B. Linck, H. Luss, J. Neumann, and W. Schmitz (2001)
Cardiovasc Res 52, 95-102
   Abstract »    Full Text »    PDF »
Electrostatic control of half-site spacing preferences by the cyclic AMP response element-binding protein CREB.
J. K. Montclare, L. S. Sloan, and A. Schepartz (2001)
Nucleic Acids Res. 29, 3311-3319
   Abstract »    Full Text »    PDF »
Suppression of T-cell responsiveness by inducible cAMP early repressor (ICER).
J. Bodor, L. Feigenbaum, J. Bodorova, C. Bare, M. S. Reitz Jr, and R. E. Gress (2001)
J. Leukoc. Biol. 69, 1053-1059
   Abstract »    Full Text »    PDF »
CREB-H: a novel mammalian transcription factor belonging to the CREB/ATF family and functioning via the box-B element with a liver-specific expression.
Y. Omori, J.-i. Imai, M. Watanabe, T. Komatsu, Y. Suzuki, K. Kataoka, S. Watanabe, A. Tanigami, and S. Sugano (2001)
Nucleic Acids Res. 29, 2154-2162
   Abstract »    Full Text »    PDF »
Multiple Signals Required for Cyclic AMP-Responsive Element Binding Protein (CREB) Binding Protein Interaction Induced by CD3/CD28 Costimulation.
C.-T. Yu, H.-m. Shih, and M.-Z. Lai (2001)
J. Immunol. 166, 284-292
   Abstract »    Full Text »    PDF »
DREAM-alpha CREM Interaction via Leucine-Charged Domains Derepresses Downstream Regulatory Element-Dependent Transcription.
F. Ledo, A. M. Carrión, W. A. Link, B. Mellström, and J. R. Naranjo (2000)
Mol. Cell. Biol. 20, 9120-9126
   Abstract »    Full Text »
Novel Cyclic Adenosine 3',5'-Monophosphate (cAMP) Response Element Modulator {theta} Isoforms Expressed by Two Newly Identified cAMP-Responsive Promoters Active in the Testis.
P. B. Daniel, L. Rohrbach, and J. F. Habener (2000)
Endocrinology 141, 3923-3930
   Abstract »    Full Text »    PDF »
Homocysteine-responsive ATF3 gene expression in human vascular endothelial cells: activation of c-Jun NH2-terminal kinase and promoter response element.
Y. Cai, C. Zhang, T. Nawa, T. Aso, M. Tanaka, S. Oshiro, H. Ichijo, and S. Kitajima (2000)
Blood 96, 2140-2148
   Abstract »    Full Text »    PDF »
Defective Th Function Induced by a Dominant-Negative cAMP Response Element Binding Protein Mutation Is Reversed by Bcl-2.
F. Zhang, M. Rincon, R. A. Flavell, and T. M. Aune (2000)
J. Immunol. 165, 1762-1770
   Abstract »    Full Text »    PDF »
Expression of the cyclic AMP-dependent transcription factors, CREB, CREM and ATF2, in the human myometrium during pregnancy and labour.
J. Bailey, C. Sparey, R. J. Phillips, K. Gilmore, S. C. Robson, W. Dunlop, and G.N. Europe-Finner (2000)
Mol. Hum. Reprod. 6, 648-660
   Abstract »    Full Text »    PDF »
Aca1 and Aca2, ATF/CREB Activators in Saccharomyces cerevisiae, Are Important for Carbon Source Utilization but Not the Response to Stress.
M. A. Garcia-Gimeno and K. Struhl (2000)
Mol. Cell. Biol. 20, 4340-4349
   Abstract »    Full Text »
Lineage-specific regulation of the murine RAG-2 promoter: GATA-3 in T cells and Pax-5 in B cells.
H. Kishi, X.-C. Wei, Z.-X. Jin, Y. Fujishiro, T. Nagata, T. Matsuda, and A. Muraguchi (2000)
Blood 95, 3845-3852
   Abstract »    Full Text »    PDF »
Role of the Cyclic AMP Response Element Binding Complex and Activation of Mitogen-Activated Protein Kinases in Synergistic Activation of the Glycoprotein Hormone alpha Subunit Gene by Epidermal Growth Factor and Forskolin.
M. S. Roberson, M. Ban, T. Zhang, and J. M. Mulvaney (2000)
Mol. Cell. Biol. 20, 3331-3344
   Abstract »    Full Text »
Transduction of a murine dominant negative activation transcription factor 1 increases cell surface expression of the class I MHC on a human epidermoid tumor cell line.
A. Ishizu, K. Sawai, H. Ikeda, T. Hirano, N. Ishiguro, and D. Meruelo (2000)
Int. Immunol. 12, 161-168
   Abstract »    Full Text »    PDF »
Synergistic Activation of the Inhibin {alpha}-Promoter by Steroidogenic Factor-1 and Cyclic Adenosine 3',5'-Monophosphate.
M. Ito, Y. Park, J. Weck, K. E. Mayo, and J. L. Jameson (2000)
Mol. Endocrinol. 14, 66-81
   Abstract »    Full Text »
Identification and Functional Analysis of Novel cAMP Response Element Binding Protein Splice Variants Lacking the Basic/Leucine Zipper Domain.
N. Sakai, L. M. Tolbert, and R. S. Duman (1999)
Mol. Pharmacol. 56, 917-925
   Abstract »    Full Text »
Characterization of Osf1, an Osteoblast-specific Transcription Factor Binding to a Critical cis-acting Element in the Mouse Osteocalcin Promoters.
T. Schinke and G. Karsenty (1999)
J. Biol. Chem. 274, 30182-30189
   Abstract »    Full Text »    PDF »
DNA specificity enhanced by sequential binding of protein monomers.
J. J. Kohler, S. J. Metallo, T. L. Schneider, and A. Schepartz (1999)
PNAS 96, 11735-11739
   Abstract »    Full Text »    PDF »
The Cyclic AMP Response Element Modulator Family Regulates the Insulin Gene Transcription by Interacting with Transcription Factor IID.
A. Inada, Y. Someya, Y. Yamada, Y. Ihara, A. Kubota, N. Ban, R. Watanabe, K. Tsuda, and Y. Seino (1999)
J. Biol. Chem. 274, 21095-21103
   Abstract »    Full Text »    PDF »
A Dominant Role for the Raf-MEK Pathway in Forskolin, 12-O-Tetradecanoyl-phorbol Acetate, and Platelet-Derived Growth Factor-Induced CREB (cAMP-Responsive Element-Binding Protein) Activation, Uncoupled from Serine 133 Phosphorylation in NIH 3T3 Cells.
O. M. Seternes, B. Johansen, and U. Moens (1999)
Mol. Endocrinol. 13, 1071-1083
   Abstract »    Full Text »
Functional Analysis of the Mouse ICER (Inducible cAMP Early Repressor) Promoter: Evidence for a Protein That Blocks Calcium Responsiveness of the CAREs (cAMP Autoregulatory Elements).
D. A. Krueger, D. Mao, E. A. Warner, and D. R. Dowd (1999)
Mol. Endocrinol. 13, 1207-1217
   Abstract »    Full Text »
ATF-2 Is a Common Nuclear Target of Smad and TAK1 Pathways in Transforming Growth Factor-beta Signaling.
Y. Sano, J. Harada, S. Tashiro, R. Gotoh-Mandeville, T. Maekawa, and S. Ishii (1999)
J. Biol. Chem. 274, 8949-8957
   Abstract »    Full Text »    PDF »
Repetitive transcranial magnetic stimulation activates specific regions in rat brain.
R.-R. Ji, T. E. Schlaepfer, C. D. Aizenman, C. M. Epstein, D. Qiu, J. C. Huang, and F. Rupp (1998)
PNAS 95, 15635-15640
   Abstract »    Full Text »    PDF »
Identification of the cis-Acting Endoplasmic Reticulum Stress Response Element Responsible for Transcriptional Induction of Mammalian Glucose-regulated Proteins. INVOLVEMENT OF BASIC LEUCINE ZIPPER TRANSCRIPTION FACTORS.
H. Yoshida, K. Haze, H. Yanagi, T. Yura, and K. Mori (1998)
J. Biol. Chem. 273, 33741-33749
   Abstract »    Full Text »    PDF »
Transcription of a Minimal Promoter from the NF-IL6 Gene Is Regulated by CREB/ATF and SP1 Proteins in U937 Promonocytic Cells.
A. Berrier, G. Siu, and K. Calame (1998)
J. Immunol. 161, 2267-2275
   Abstract »    Full Text »    PDF »
A Protein Kinase C-, Ras-, and RSK2-dependent Signal Transduction Pathway Activates the cAMP-responsive Element-binding Protein Transcription Factor following T Cell Receptor Engagement.
N. Muthusamy and J. M. Leiden (1998)
J. Biol. Chem. 273, 22841-22847
   Abstract »    Full Text »    PDF »
Assessment of the Roles of Mitogen-activated Protein Kinase, Phosphatidylinositol 3-Kinase, Protein Kinase B, and Protein Kinase C in Insulin Inhibition of cAMP-induced Phosphoenolpyruvate Carboxykinase Gene Transcription.
J. M. Agati, D. Yeagley, and P. G. Quinn (1998)
J. Biol. Chem. 273, 18751-18759
   Abstract »    Full Text »    PDF »
Isolation and Analysis of a T Cell Clone Variant Exhibiting Constitutively Phosphorylated Ser133 cAMP Response Element-Binding Protein.
S. M. Belkowski, C. S. Rubin, and M. B. Prystowsky (1998)
J. Immunol. 161, 659-665
   Abstract »    Full Text »    PDF »
The Regulation of Murine H-2Dd Expression by Activation Transcription Factor 1 and cAMP Response Element Binding Protein.
N. Ishiguro, G. D. Brown, A. Ishizu, and D. Meruelo (1998)
J. Immunol. 160, 5907-5914
   Abstract »    Full Text »    PDF »
Gonadotropins Regulate Inducible Cyclic Adenosine 3',5'-Monophosphate Early Repressor in the Rat Ovary: Implications for Inhibin {alpha} Subunit Gene Expression.
A. Mukherjee, J. Urban, P. Sassone-Corsi, and K. E. Mayo (1998)
Mol. Endocrinol. 12, 785-800
   Abstract »    Full Text »
Role of Transcriptional Repressor ICER in Cyclic AMP-mediated Attenuation of Cytokine Gene Expression in Human Thymocytes.
J. Bodor and J. F. Habener (1998)
J. Biol. Chem. 273, 9544-9551
   Abstract »    Full Text »    PDF »
A Dominant-Negative Inhibitor of CREB Reveals that It Is a General Mediator of Stimulus-Dependent Transcription of c-fos.
S. Ahn, M. Olive, S. Aggarwal, D. Krylov, D. D. Ginty, and C. Vinson (1998)
Mol. Cell. Biol. 18, 967-977
   Abstract »    Full Text »
The maize gene liguleless2 encodes a basic leucine zipper protein involved in the establishment of the leaf blade-sheath boundary.
J. Walsh, C. A. Waters, and M. Freeling (1998)
Genes & Dev. 12, 208-218
   Abstract »    Full Text »    PDF »
Regulation of Sexual Dimorphism in Mammals.
C. M. HAQQ and P. K. DONAHOE (1998)
Physiol Rev 78, 1-33
   Abstract »    Full Text »    PDF »
Both the Cyclic AMP Response Element and the Activator Protein 2 Binding Site Mediate Basal and Cyclic AMP-Induced Transcription from the Dominant Promoter of the Rat alpha 1B-Adrenergic Receptor Gene in DDT1MF-2 Cells.
B. Gao, J. Chen, C. Johnson, and G. Kunos (1997)
Mol. Pharmacol. 52, 1019-1026
   Abstract »    Full Text »
Msx1 Is Present in Thyrotropic Cells and Binds to a Consensus Site on the Glycoprotein Hormone {alpha}-Subunit Promoter.
V. D. Sarapura, H. L. Strouth, D. F. Gordon, W. M. Wood, and E. C. Ridgway (1997)
Mol. Endocrinol. 11, 1782-1794
   Abstract »    Full Text »
Multiple Characteristics of a Pentameric Regulatory Array Endow the Human {alpha}-Subunit Glycoprotein Hormone Promoter with Trophoblast Specificity and Maximal Activity.
P. R. Budworth, P. G. Quinn, and J. H. Nilson (1997)
Mol. Endocrinol. 11, 1669-1680
   Abstract »    Full Text »
Characterization of Human Activating Transcription Factor 4, a Transcriptional Activator That Interacts with Multiple Domains of cAMP-responsive Element-binding Protein (CREB)-binding Protein (CBP).
G. Liang and T. Hai (1997)
J. Biol. Chem. 272, 24088-24095
   Abstract »    Full Text »    PDF »
The Dynamics of the Transcriptional Response to Cyclic Adenosine 3',5'-Monophosphate: Recurrent Inducibility and Refractory Phase.
M. Lamas and P. Sassone-Corsi (1997)
Mol. Endocrinol. 11, 1415-1424
   Abstract »    Full Text »
Regulation of Major Histocompatibility Complex Class I Gene Expression in Thyroid Cells. ROLE OF THE cAMP RESPONSE ELEMENT-LIKE SEQUENCE.
M. Saji, M. Shong, G. Napolitano, L. A. Palmer, S.-I. Taniguchi, M. Ohmori, M. Ohta, K. Suzuki, S. L. Kirshner, C. Giuliani, et al. (1997)
J. Biol. Chem. 272, 20096-20107
   Abstract »    Full Text »    PDF »
Protein Kinase A Activation of the Surfactant Protein B Gene Is Mediated by Phosphorylation of Thyroid Transcription Factor 1.
C. Yan and J. A. Whitsett (1997)
J. Biol. Chem. 272, 17327-17332
   Abstract »    Full Text »    PDF »
Regulation of the Human Chorionic Gonadotropin alpha - and beta -Subunit Promoters by AP-2.
W. Johnson, C. Albanese, S. Handwerger, T. Williams, R. G. Pestell, and J. L. Jameson (1997)
J. Biol. Chem. 272, 15405-15412
   Abstract »    Full Text »    PDF »
Glutamate, But Not Dopamine, Stimulates Stress-Activated Protein Kinase and AP-1-Mediated Transcription in Striatal Neurons.
M. A. Schwarzschild, R. L. Cole, and S. E. Hyman (1997)
J. Neurosci. 17, 3455-3466
   Abstract »    Full Text »    PDF »
A Novel Human Zinc Finger Protein That Interacts with the Core Promoter Element of a TATA Box-less Gene.
N. P. Koritschoner, J. L. Bocco, G. M. Panzetta-Dutari, C. I. Dumur, A. Flury, and L. C. Patrito (1997)
J. Biol. Chem. 272, 9573-9580
   Abstract »    Full Text »    PDF »
Human Endometrial Stromal Cells Express Novel Isoforms of the Transcriptional Modulator CREM and Up-Regulate ICER in the Course of Decidualization.
B. Gellersen, R. Kempf, and R. Telgmann (1997)
Mol. Endocrinol. 11, 97-113
   Abstract »    Full Text »
The Human Gene for the Regulatory Subunit RI{alpha} of Cyclic Adenosine 3',5'-Monophosphate-Dependent Protein Kinase: Two Distinct Promoters Provide Differential Regulation of Alternately Spliced Messenger Ribonucleic Acids.
R. Solberg, M. Sandberg, V. Natarajan, P. A. Torjesen, V. Hansson, T. Jahnsen, and K. Tasken (1997)
Endocrinology 138, 169-181
   Abstract »    Full Text »    PDF »
Human Activin beta A Gene. IDENTIFICATION OF NOVEL 5prime EXON, FUNCTIONAL PROMOTER, AND ENHANCERS.
K. Tanimoto, E. Yoshida, S. Mita, Y. Nibu, K. Murakami, and A. Fukamizu (1996)
J. Biol. Chem. 271, 32760-32769
   Abstract »    Full Text »    PDF »
The Proximal Regulatory Element of the Interferon-gamma Promoter Mediates Selective Expression in T Cells.
L. A. Penix, M. T. Sweetser, W. M. Weaver, J. P. Hoeffler, T. K. Kerppola, and C. B. Wilson (1996)
J. Biol. Chem. 271, 31964-31972
   Abstract »    Full Text »    PDF »
The cAMP Response Elements of the alpha Subunit Gene Bind Similar Proteins in Trophoblasts and Gonadotropes but Have Distinct Functional Sequence Requirements.
L. L. Heckert, K. Schultz, and J. H. Nilson (1996)
J. Biol. Chem. 271, 31650-31656
   Abstract »    Full Text »    PDF »
Transcriptional control of circadian hormone synthesis via the CREM feedback loop.
N. S. Foulkes, J. Borjigin, S. H. Snyder, and P. Sassone-Corsi (1996)
PNAS 93, 14140-14145
   Abstract »    Full Text »    PDF »
Identification and Characterization of Basal and Cyclic AMP Response Elements in the Promoter of the Rat Hexokinase II Gene.
H. Osawa, R. B. Robey, R. L. Printz, and D. K. Granner (1996)
J. Biol. Chem. 271, 17296-17303
   Abstract »    Full Text »    PDF »
Amphetamine and Dopamine-Induced Immediate Early Gene Expression in Striatal Neurons Depends on Postsynaptic NMDA Receptors and Calcium.
C. Konradi, J.-C. Leveque, and S. E. Hyman (1996)
J. Neurosci. 16, 4231-4239
   Abstract »    Full Text »    PDF »
Neuronal Activity Increases the Phosphorylation of the Transcription Factor cAMP Response Element-binding Protein (CREB) in Rat Hippocampus and Cortex.
A. N. Moore, M. N. Waxham, and P. K. Dash (1996)
J. Biol. Chem. 271, 14214-14220
   Abstract »    Full Text »    PDF »
Intramolecular inhibition of activating transcription factor-2 function by its DNA-binding domain..
X Y Li and M R Green (1996)
Genes & Dev. 10, 517-527
   Abstract »    PDF »
ATF3 Gene.
G. Liang, C. D. Wolfgang, B. P. C. Chen, T.-H. Chen, and T. Hai (1996)
J. Biol. Chem. 271, 1695-1701
   Abstract »    Full Text »    PDF »
Rhythmic Transcription and Autoregulatory Loops: Nuclear Pacemaker CREM.
M. Lamas, E. Lalli, N.S. Foulkes, and P. Sassone-Corsi (1996)
Cold Spring Harb Symp Quant Biol 61, 285-294
   Abstract »    PDF »
Ischemia and Reperfusion Enhance ATF-2 and c-Jun Binding to cAMP Response Elements and to an AP-1 Binding Site from the c-jun Promoter.
H. Morooka, J. V. Bonventre, C. M. Pombo, J. M. Kyriakis, and T. Force (1995)
J. Biol. Chem. 270, 30084-30092
   Abstract »    Full Text »    PDF »
Transcription of Cystic Fibrosis Transmembrane Conductance Regulator Requires a CCAAT-like Element for both Basal and cAMP-mediated Regulation.
N. Pittman, G. Shue, N. S. LeLeiko, and M. J. Walsh (1995)
J. Biol. Chem. 270, 28848-28857
   Abstract »    Full Text »    PDF »
The Cyclic AMP Response Element Directs Tyrosine Hydroxylase Expression in Catecholaminergic Central and Peripheral Nervous System Cell Lines from Transgenic Mice.
M. Lazaroff, S. Patankar, S. O. Yoon, and D. M. Chikaraishi (1995)
J. Biol. Chem. 270, 21579-21589
   Abstract »    Full Text »    PDF »
cAMP Response Element-binding Protein (CREB) Interacts with Transcription Factors IIB and IID.
L. Xing, V. K. Gopal, and P. G. Quinn (1995)
J. Biol. Chem. 270, 17488-17493
   Abstract »    Full Text »    PDF »
Involvement of the Ca[IMAGE]-dependent Phosphatase Calcineurin in Gene Transcription That Is Stimulated by cAMP through cAMP Response Elements.
M. Schwaninger, R. Blume, M. Krüger, G. Lux, E. Oetjen, and W. Knepel (1995)
J. Biol. Chem. 270, 8860-8866
   Abstract »    Full Text »    PDF »
The cAMP response element binding protein is involved in hydra regeneration.
B Galliot, M Welschof, O Schuckert, S Hoffmeister, and H. Schaller (1995)
Development 121, 1205-1216
   Abstract »    PDF »
Differential activation of CREB by Ca2+/calmodulin-dependent protein kinases type II and type IV involves phosphorylation of a site that negatively regulates activity..
P Sun, H Enslen, P S Myung, and R A Maurer (1994)
Genes & Dev. 8, 2527-2539
   Abstract »    PDF »
DNA bending and orientation-dependent function of YY1 in the c-fos promoter..
S Natesan and M Z Gilman (1993)
Genes & Dev. 7, 2497-2509
   Abstract »    PDF »
Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia.
T Inaba, W. Roberts, L. Shapiro, K. Jolly, S. Raimondi, S. Smith, and A. Look (1992)
Science 257, 531-534
   Abstract »    PDF »
A Drosophila CREB/ATF transcriptional activator binds to both fat body- and liver-specific regulatory elements..
T Abel, R Bhatt, and T Maniatis (1992)
Genes & Dev. 6, 466-480
   Abstract »    PDF »
Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells..
Z Cao, R M Umek, and S L McKnight (1991)
Genes & Dev. 5, 1538-1552
   Abstract »    PDF »
A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro..
S C Williams, C A Cantwell, and P F Johnson (1991)
Genes & Dev. 5, 1553-1567
   Abstract »    PDF »
CREB: a Ca(2+)-regulated transcription factor phosphorylated by calmodulin-dependent kinases.
M Sheng, M. Thompson, and M. Greenberg (1991)
Science 252, 1427-1430
   Abstract »    PDF »
HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein interactions.
H. Maguire, J. Hoeffler, and A Siddiqui (1991)
Science 252, 842-844
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)