Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 9 December 1988:
Vol. 242. no. 4884, pp. 1424 - 1427
DOI: 10.1126/science.2462278
Prev | Table of Contents | Next

Articles

Science, Vol 242, Issue 4884, 1424-1427
Copyright © 1988 by American Association for the Advancement of Science

articles

Growth factors regulate transin gene expression by c-fos-dependent and c-fos-independent pathways

LD Kerr, JT Holt, and LM Matrisian

Department of Cell Biology, Vanderbilt University, Nashville, TN 37232.

The rapid induction of the proto-oncogene c-fos by growth factors and other bioactive agents, and the recent evidence that the c-fos protein (Fos) is associated with transcriptional complexes, suggests that Fos may represent an integral part of an intracellular messenger pathway that triggers changes in gene expression and ultimately phenotypic alterations. This report examines the role of c-fos in growth factor stimulation of transin, a matrix-degrading secreted metalloproteinase. Platelet-derived growth factor (PDGF) stimulation of transin RNA was blocked by a selective reduction in Fos synthesis with antisense c-fos mRNA, whereas epidermal growth factor (EGF) stimulation of transin occurred despite an equivalent inhibition of Fos levels. The stimulatory effect of both PDGF and EGF on transin transcription involved factors recognizing the sequence TGAGTCA, which is found in the transin promoter and is reported to be a binding site for the transcriptional factor Jun/AP-1 and for associated Fos and Fos-related complexes. Thus both Fos-dependent and Fos-independent pathways exist for growth factor regulation of gene expression, and both effects may be mediated through the same cis-acting transcription element.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Fast regulation of AP-1 activity through interaction of lamin A/C, ERK1/2, and c-Fos at the nuclear envelope.
J. M. Gonzalez, A. Navarro-Puche, B. Casar, P. Crespo, and V. Andres (2008)
J. Cell Biol. 183, 653-666
   Abstract »    Full Text »    PDF »
Spontaneous activation of the NF-{kappa}B signaling pathway in isolated normal glomeruli.
K. Hayakawa, Y. Meng, N. Hiramatsu, A. Kasai, J. Yao, and M. Kitamura (2006)
Am J Physiol Renal Physiol 291, F1169-F1176
   Abstract »    Full Text »    PDF »
Phosphorylation of the Carboxyl-Terminal Transactivation Domain of c-Fos by Extracellular Signal-Regulated Kinase Mediates the Transcriptional Activation of AP-1 and Cellular Transformation Induced by Platelet-Derived Growth Factor.
P. Monje, M. J. Marinissen, and J. S. Gutkind (2003)
Mol. Cell. Biol. 23, 7030-7043
   Abstract »    Full Text »    PDF »
Role of Middle T-Small T in the Lytic Cycle of Polyomavirus: Control of the Early-to-Late Transcriptional Switch and Viral DNA Replication.
L. Chen and M. M. Fluck (2001)
J. Virol. 75, 8380-8389
   Abstract »    Full Text »    PDF »
Spontaneous shift in transcriptional profile of explanted glomeruli via activation of the MAP kinase family.
Y. Ishikawa, T. Konta, and M. Kitamura (2000)
Am J Physiol Renal Physiol 279, F954-F959
   Abstract »    Full Text »    PDF »
Macrophage Migration Inhibitory Factor Up-regulates Expression of Matrix Metalloproteinases in Synovial Fibroblasts of Rheumatoid Arthritis.
S. Onodera, K. Kaneda, Y. Mizue, Y. Koyama, M. Fujinaga, and J. Nishihira (2000)
J. Biol. Chem. 275, 444-450
   Abstract »    Full Text »    PDF »
Platelet-Derived Growth Factor Stimulates Heme Oxygenase-1 Gene Expression and Carbon Monoxide Production in Vascular Smooth Muscle Cells.
W. Durante, K. J. Peyton, and A. I. Schafer (1999)
Arterioscler Thromb Vasc Biol 19, 2666-2672
   Abstract »    Full Text »    PDF »
Stable Overexpression of Manganese Superoxide Dismutase in Mitochondria Identifies Hydrogen Peroxide as a Major Oxidant in the AP-1-mediated Induction of Matrix-degrading Metalloprotease-1.
J. Wenk, P. Brenneisen, M. Wlaschek, A. Poswig, K. Briviba, T. D. Oberley, and K. Scharffetter-Kochanek (1999)
J. Biol. Chem. 274, 25869-25876
   Abstract »    Full Text »    PDF »
Functions of c-Jun in Liver and Heart Development.
R. Eferl, M. Sibilia, F. Hilberg, A. Fuchsbichler, I. Kufferath, B. Guertl, R. Zenz, E. F. Wagner, and K. Zatloukal (1999)
J. Cell Biol. 145, 1049-1061
   Abstract »    Full Text »    PDF »
Suppression of Postischemic Hippocampal Nerve Growth Factor Expression by a c-fos Antisense Oligodeoxynucleotide.
J.-K. Cui, C. Y. Hsu, and P. K. Liu (1999)
J. Neurosci. 19, 1335-1344
   Abstract »    Full Text »    PDF »
Fra-1 Induces Morphological Transformation and Increases In Vitro Invasiveness and Motility of Epithelioid Adenocarcinoma Cells.
O. Kustikova, D. Kramerov, M. Grigorian, V. Berezin, E. Bock, E. Lukanidin, and E. Tulchinsky (1998)
Mol. Cell. Biol. 18, 7095-7105
   Abstract »    Full Text »    PDF »
Finkel-Biskis-Reilly Osteosarcoma Virus v-Fos Inhibits Adipogenesis and Both the Activity and Expression of CCAAT/Enhancer Binding Protein alpha , a Key Regulator of Adipocyte Differentiation.
D. W. Abbott and J. T. Holt (1997)
J. Biol. Chem. 272, 32454-32462
   Abstract »    Full Text »    PDF »
Hypoxia Induces c-fos Transcription via a Mitogen-activated Protein Kinase-dependent Pathway.
J. M. Muller, B. Krauss, C. Kaltschmidt, P. A. Baeuerle, and R. A. Rupec (1997)
J. Biol. Chem. 272, 23435-23439
   Abstract »    Full Text »    PDF »
Expression of Matrix Metalloproteinases and Their Inhibitor TIMP-1 in the Rat Carotid Artery After Balloon Injury.
K. E. Webb, A. M. Henney, S. Anglin, S. E. Humphries, and J. R. McEwan (1997)
Arterioscler Thromb Vasc Biol 17, 1837-1844
   Abstract »    Full Text »
Phosphocitrate Inhibits a Basic Calcium Phosphate and Calcium Pyrophosphate Dihydrate Crystal-induced Mitogen-activated Protein Kinase Cascade Signal Transduction Pathway.
D. Nair, R. P. Misra, J. D. Sallis, and H. S. Cheung (1997)
J. Biol. Chem. 272, 18920-18925
   Abstract »    Full Text »    PDF »
Absence of a Persistently Elevated 37 kDa Fos-Related Antigen and AP-1-Like DNA-Binding Activity in the Brains of Kainic Acid-Treated fosB Null Mice.
A. Mandelzys, M. A. Gruda, R. Bravo, and J. I. Morgan (1997)
J. Neurosci. 17, 5407-5415
   Abstract »    Full Text »    PDF »
Finkel-Biskis-Reilly Mouse Osteosarcoma Virus v-fos Inhibits the Cellular Response to Ionizing Radiation in a Myristoylation-dependent Manner.
D. W. Abbott and J. T. Holt (1997)
J. Biol. Chem. 272, 14005-14008
   Abstract »    Full Text »    PDF »
Thapsigargin-Induced Gene Expression in Nonexcitable Cells Is Dependent on Calcium Influx.
K. D. Rodland, R. P. Wersto, S. Hobson, and E. C. Kohn (1997)
Mol. Endocrinol. 11, 281-291
   Abstract »    Full Text »
Upregulation of c-Fos in Activated T Lymphoid and Monocytic Cells by Human Immunodeficiency Virus-1 Tat Protein.
D. Gibellini, A. Caputo, S. Capitani, M. La Placa, and G. Zauli (1997)
Blood 89, 1654-1664
   Abstract »    Full Text »    PDF »
Cross-talk between Different Enhancer Elements during Mitogenic Induction of the Human Stromelysin-1 Gene.
M. Kirstein, L. Sanz, S. Quinones, J. Moscat, MariaT. Diaz-Meco, and J. Saus (1996)
J. Biol. Chem. 271, 18231-18236
   Abstract »    Full Text »    PDF »
Progression of Coronary Atherosclerosis Is Associated with a Common Genetic Variant of the Human Stromelysin-1 Promoter Which Results in Reduced Gene Expression.
S. Ye, P. Eriksson, A. Hamsten, M. Kurkinen, S. E. Humphries, and A. M. Henney (1996)
J. Biol. Chem. 271, 13055-13060
   Abstract »    Full Text »    PDF »
AP-1/Jun Is Required for Early Xenopus Development and Mediates Mesoderm Induction by Fibroblast Growth Factor but Not by Activin.
Z. Dong, R.-H. Xu, J. Kim, S.-N. Zhan, W.-Y. Ma, N. H. Colburn, and H.-f. Kung (1996)
J. Biol. Chem. 271, 9942-9946
   Abstract »    Full Text »    PDF »
Synergistic Transcriptional Activation of the Tissue Inhibitor of Metalloproteinases-1 Promoter via Functional Interaction of AP-1 and Ets-1 Transcription Factors.
S. K. Logan, M. J. Garabedian, C. E. Campbell, and Z. Werb (1996)
J. Biol. Chem. 271, 774-782
   Abstract »    Full Text »    PDF »
A Novel Nerve Growth Factor-responsive Element in the Stromelysin-1 (Transin) Gene That Is Necessary and Sufficient for Gene Expression in PC12 Cells.
S. deSouza, J. Lochner, C. M. Machida, L. M. Matrisian, and G. Ciment (1995)
J. Biol. Chem. 270, 9106-9114
   Abstract »    Full Text »    PDF »
Epidermal Growth Factor Stimulation of the Human Gastrin Promoter Requires Sp1.
J. L. Merchant, A. Shiotani, E. R. Mortensen, D. K. Shumaker, and D. R. Abraczinskas (1995)
J. Biol. Chem. 270, 6314-6319
   Abstract »    Full Text »    PDF »
Matrix Metalloproteinases: A Review.
H. Birkedal-Hansen, W.G.I. Moore, M.K. Bodden, L.J. Windsor, B. Birkedal-Hansen, A. DeCarlo, and J.A. Engler (1993)
Critical Reviews in Oral Biology & Medicine 4, 197-250
   Abstract »    Full Text »    PDF »
Transformation by FosB requires a trans-activation domain missing in FosB2 that can be substituted by heterologous activation domains..
R Wisdom, J Yen, D Rashid, and I M Verma (1992)
Genes & Dev. 6, 667-675
   Abstract »    PDF »
Nerve growth factor regulates tyrosine hydroxylase gene transcription through a nucleoprotein complex that contains c-Fos..
E Gizang-Ginsberg and E B Ziff (1990)
Genes & Dev. 4, 477-491
   Abstract »    PDF »
G1 events and regulation of cell proliferation.
A. Pardee (1989)
Science 246, 603-608
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)