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Science 25 November 1988:
Vol. 242. no. 4882, pp. 1174 - 1176
DOI: 10.1126/science.2460926
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Articles

Science, Vol 242, Issue 4882, 1174-1176
Copyright © 1988 by American Association for the Advancement of Science

articles

Demethylated CD8 gene in CD4+ T cells suggests that CD4+ cells develop from CD8+ precursors

AM Carbone, P Marrack, and JW Kappler

Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO.

Mature T cells and medullary thymocytes bear either the CD4 or CD8 differentiation antigen. Precursor cells in the thymus express neither CD4 nor CD8 (CD4-8-), but most cortical thymocytes are CD4+8+. Whether CD4+ and CD8+ mature T cells arise directly from CD4-8- precursors or from a CD4+8+ intermediate remains unresolved. In this study, methylation of the CD8 gene in murine T cells and thymocytes was examined. There was progressive demethylation of the CD8 gene in the thymus during the transition from CD4-8- to CD4+8+. A similar pattern of demethylation of the CD8 gene was seen in CD4+ mature T cells, suggesting previous expression of CD8 in the CD4+ lineage.


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CD4 Promotes Breadth in the TCR Repertoire.
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Differential Regulation of Methionine Adenosyltransferase in Superantigen and Mitogen Stimulated Human T Lymphocytes.
H L. LeGros Jr., A. M. Geller, and M. Kotb (1997)
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