Science 11 November 1988: Vol. 242. no. 4880, pp. 933 - 935 DOI: 10.1126/science.3263702

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Brain-derived neurotrophic factor enhances the excitability of rat sensory neurons through activation of the p75 neurotrophin receptor and the sphingomyelin pathway.

Y. H. Zhang, X. X. Chi, and G. D. Nicol (2008)
J. Physiol. 586, 3113-3127
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Requirement of hypoxia-inducible factor-1{alpha} down-regulation in mediating the antitumor activity of the anti-epidermal growth factor receptor monoclonal antibody cetuximab.

X. Li, Y. Lu, K. Liang, T. Pan, J. Mendelsohn, and Z. Fan (2008)
Mol. Cancer Ther. 7, 1207-1217
 |  Abstract »  |  Full Text »  |  PDF »

Pyruvate Dehydrogenase Complex Deficiency Caused by Ubiquitination and Proteasome-mediated Degradation of the E1 Subunit.

Z. Han, L. Zhong, A. Srivastava, and P. W. Stacpoole (2008)
J. Biol. Chem. 283, 237-243
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Tyrphostin A8 stimulates a novel trafficking pathway of apically endocytosed transferrin through Rab11-enriched compartments in Caco-2 cells.

F. Norouziyan, W.-C. Shen, and S. F. Hamm-Alvarez (2008)
Am J Physiol Cell Physiol 294, C7-C21
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PTEN-Mediated Resistance to Epidermal Growth Factor Receptor Kinase Inhibitors.

I. K. Mellinghoff, T. F. Cloughesy, and P. S. Mischel (2007)
Clin. Cancer Res. 13, 378-381
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Chronic myeloid leukemia: Standard treatment options..

D. Frame (2006)
Am. J. Health Syst. Pharm. 63, S10-S14
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Tumor Endothelial Cells Express Epidermal Growth Factor Receptor (EGFR) but not ErbB3 and Are Responsive to EGF and to EGFR Kinase Inhibitors.

D. N. Amin, K. Hida, D. R. Bielenberg, and M. Klagsbrun (2006)
Cancer Res. 66, 2173-2180
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Insulin Receptor Substrate Is a Mediator of Phosphoinositide 3-Kinase Activation in Quiescent Pancreatic Cancer Cells.

T. Asano, Y. Yao, S. Shin, J. McCubrey, J. L. Abbruzzese, and S. A.G. Reddy (2005)
Cancer Res. 65, 9164-9168
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Enhanced Efficacy of Radioimmunotherapy with 90Y-CHX-A''-DTPA-hu3S193 by Inhibition of Epidermal Growth Factor Receptor (EGFR) Signaling with EGFR Tyrosine Kinase Inhibitor AG1478.

F. T. Lee, A. J. Mountain, M. P. Kelly, C. Hall, A. Rigopoulos, T. G. Johns, F. E. Smyth, M. W. Brechbiel, E. C. Nice, A. W. Burgess, et al. (2005)
Clin. Cancer Res. 11, 7080s-7086s
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PDGF receptor kinase inhibitors for the treatment of restenosis.

A. Levitzki (2005)
Cardiovasc Res 65, 581-586
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Antitumor efficacy of cytotoxic drugs and the monoclonal antibody 806 is enhanced by the EGF receptor inhibitor AG1478.

T. G. Johns, R. B. Luwor, C. Murone, F. Walker, J. Weinstock, A. A. Vitali, R. M. Perera, A. A. Jungbluth, E. Stockert, L. J. Old, et al. (2003)
PNAS 100, 15871-15876
 |  Abstract »  |  Full Text »  |  PDF »

Tyrphostin A23 Inhibits Internalization of the Transferrin Receptor by Perturbing the Interaction between Tyrosine Motifs and the Medium Chain Subunit of the AP-2 Adaptor Complex.

D. N. Banbury, J. D. Oakley, R. B. Sessions, and G. Banting (2003)
J. Biol. Chem. 278, 12022-12028
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Protein kinase antagonists inhibit invasion of mammalian cells by Fonsecaea pedrosoi.

C. L. Limongi, W. De Souza, and S. Rozental (2003)
J. Med. Microbiol. 52, 201-209
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Risk and the Efficacy of Antiinflammatory Agents: Retrospective and Confirmatory Studies of Sepsis.

P. Q. Eichacker, C. Parent, A. Kalil, C. Esposito, X. Cui, S. M. Banks, E. P. Gerstenberger, Y. Fitz, R. L. Danner, and C. Natanson (2002)
Am. J. Respir. Crit. Care Med. 166, 1197-1205
 |  Abstract »  |  Full Text »  |  PDF »

ZD1839 (Iressa): An Orally Active Inhibitor of Epidermal Growth Factor Signaling with Potential for Cancer Therapy.

A. E. Wakeling, S. P. Guy, J. R. Woodburn, S. E. Ashton, B. J. Curry, A. J. Barker, and K. H. Gibson (2002)
Cancer Res. 62, 5749-5754
 |  Abstract »  |  Full Text »  |  PDF »

Tyrphostins Protect Neuronal Cells from Oxidative Stress.

Y. Sagara, K. Ishige, C. Tsai, and P. Maher (2002)
J. Biol. Chem. 277, 36204-36215
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Regulation of Steroidogenic Genes by Insulin-Like Growth Factor-1 and Follicle-Stimulating Hormone: Differential Responses of Cytochrome P450 Side-Chain Cleavage, Steroidogenic Acute Regulatory Protein, and 3{beta}-Hydroxysteroid Dehydrogenase/Isomerase in Rat Granulosa Cells.

S. Eimerl and J. Orly (2002)
Biol Reprod 67, 900-910
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Cell Surface Antigen and Molecular Targeting in the Treatment of Hematologic Malignancies.

A. Countouriotis, T. B. Moore, and K. M. Sakamoto (2002)
Stem Cells 20, 215-229
 |  Abstract »  |  Full Text »  |  PDF »

Imatinib Mesylate -- A New Oral Targeted Therapy.

D. G. Savage and K. H. Antman (2002)
N. Engl. J. Med. 346, 683-693
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The Kinase Inhibitor PP1 Blocks Tumorigenesis Induced by RET Oncogenes.

F. Carlomagno, D. Vitagliano, T. Guida, M. Napolitano, G. Vecchio, A. Fusco, A. Gazit, A. Levitzki, and M. Santoro (2002)
Cancer Res. 62, 1077-1082
 |  Abstract »  |  Full Text »  |  PDF »

STI571: A Paradigm of New Agents for Cancer Therapeutics.

M. J. Mauro, M. O'Dwyer, M. C. Heinrich, and B. J. Druker (2002)
J. Clin. Oncol. 20, 325-334
 |  Abstract »  |  Full Text »  |  PDF »

Relaxin signalling links tyrosine phosphorylation to phosphodiesterase and adenylyl cyclase activity.

O. Bartsch, B. Bartlick, and R. Ivell (2001)
Mol. Hum. Reprod. 7, 799-809
 |  Abstract »  |  Full Text »  |  PDF »

STI571: Targeting BCR-ABL as Therapy for CML.

M. J. Mauro and B. J. Druker (2001)
Oncologist 6, 233-238
 |  Abstract »  |  Full Text »  |  PDF »

Design of a Chimeric 3-Methyl-1,2,3-triazene with Mixed Receptor Tyrosine Kinase and DNA Damaging Properties: A Novel Tumor Targeting Strategy.

S. L. Matheson, J. McNamee, and B. J. Jean-Claude (2001)
J. Pharmacol. Exp. Ther. 296, 832-840
 |  Abstract »  |  Full Text »

Clastogenic effects of two tyrosine kinase inhibitors, Tyrphostin 23 and Tyrphostin 46, on a transformed (CHO-K1) and on a primary embryonic Chinese hamster cell line (CHE).

L. Bassi, R. Buzzi, M. Fiore, and F. Palitti (2000)
Mutagenesis 15, 341-347
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The Tyrosine Kinase Inhibitor Tyrphostin AG126 Reduces the Development of Acute and Chronic Inflammation.

S. Cuzzocrea, M. C. McDonald, E. Mazzon, D. Siriwardena, G. Calabro, D. Britti, G. Mazzullo, A. De Sarro, A. P. Caputi, and C. Thiemermann (2000)
Am. J. Pathol. 157, 145-158
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The Role of Polypeptide Growth Factors in Human Carcinomas: New Targets for a Novel Pharmacological Approach.

R. E. Favoni and A. De Cupis (2000)
Pharmacol. Rev. 52, 179-206
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Mechanism of resistance to the ABL tyrosine kinase inhibitor STI571 in BCR/ABL-transformed hematopoietic cell lines.

E. Weisberg and J. D. Griffin (2000)
Blood 95, 3498-3505
 |  Abstract »  |  Full Text »  |  PDF »

Activation of Epidermal Growth Factor Receptor during Corneal Epithelial Migration.

J. D. Zieske, H. Takahashi, A. E. K. Hutcheon, and A. C. Dalbone (2000)
Invest. Ophthalmol. Vis. Sci. 41, 1346-1355
 |  Abstract »  |  Full Text »

Hypoxia Induces Transcription of the Plasminogen Activator Inhibitor-1 Gene Through Genistein-Sensitive Tyrosine Kinase Pathways in Vascular Endothelial Cells.

T. Uchiyama, M. Kurabayashi, Y. Ohyama, T. Utsugi, N. Akuzawa, M. Sato, S. Tomono, S. Kawazu, and R. Nagai (2000)
Arterioscler. Thromb. Vasc. Biol. 20, 1155-1161
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Chronic Myelogenous Leukemia: Disease Biology and Current and Future Therapeutic Strategies.

H. Kantarjian, J. V. Melo, S. Tura, S. Giralt, and M. Talpaz (2000)
Hematology 2000, 90-109
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Tyrosine Phosphorylation Regulates Rapid Endocytosis in Adrenal Chromaffin Cells.

P. G. P. Nucifora and A. P. Fox (1999)
J. Neurosci. 19, 9739-9746
 |  Abstract »  |  Full Text »  |  PDF »

Mitotic aberrations induced by carbaryl reflect tyrosine kinase inhibition with coincident up-regulation of serine/threonine protein phosphatase activity: implications for coordination of karyokinesis and cytokinesis.

A. Renglin, A.-S. Harmala-Brasken, J. E. Eriksson, and A. Onfelt (1999)
Mutagenesis 14, 327-333
 |  Abstract »  |  Full Text »  |  PDF »

Adeno-Associated Virus Type 2-Mediated Gene Transfer: Role of Epidermal Growth Factor Receptor Protein Tyrosine Kinase in Transgene Expression.

C. Mah, K. Qing, B. Khuntirat, S. Ponnazhagan, X.-S. Wang, D. M. Kube, M. C. Yoder, and A. Srivastava (1998)
J. Virol. 72, 9835-9843
 |  Abstract »  |  Full Text »  |  PDF »

Expression of Thrombomodulin in Atherosclerotic Lesions and Mitogenic Activity of Recombinant Thrombomodulin in Vascular Smooth Muscle Cells.

G. Tohda, K. Oida, Y. Okada, S. Kosaka, E. Okada, S. Takahashi, H. Ishii, and I. Miyamori (1998)
Arterioscler. Thromb. Vasc. Biol. 18, 1861-1869
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of the Interaction between Tyrosine-based Motifs and the Medium Chain Subunit of the AP-2 Adaptor Complex by Specific Tyrphostins.

C. M. Crump, J. L. Williams, D. J. Stephens, and G. Banting (1998)
J. Biol. Chem. 273, 28073-28077
 |  Abstract »  |  Full Text »  |  PDF »

Epidermal Growth Factor (EGF) Modulates Fetal Thymocyte Growth and Differentiation: Partial Reversal by Insulin, Mimicking by Specific Inhibitors of EGF Receptor Tyrosine Kinase Activity, and Differential Expression of CD45 Phosphatase Isotypes.

C. S. Freitas, S. R. Dalmau, and W. Savino (1998)
J. Immunol. 161, 3384-3392
 |  Abstract »  |  Full Text »  |  PDF »

A Model for Signal Transduction during Gamete Release in the Fucoid Alga Pelvetia compressa.

G. Anthony Pearson and S. Howard Brawley (1998)
Plant Physiology 118, 305-313
 |  Abstract »  |  Full Text »

Signal Transduction during Legionella pneumophila Entry into Human Monocytes.

P. Y. Coxon, J. T. Summersgill, J. A. Ramirez, and R. D. Miller (1998)
Infect. Immun. 66, 2905-2913
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of C-Abl Tyrosine Kinase in Lipopolysaccharide- Induced Macrophage Activation.

Q. Le, R. Daniel, S.-W. Chung, A. D. Kang, T. K. Eisenstein, B. M. Sultzer, H. Simpkins, and P. M. C. Wong (1998)
J. Immunol. 160, 3330-3336
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of vascular angiotensin II receptors by EGF.

M. E. Ullian, J. R. Raymond, M. C. Willingham, and R. V. Paul (1997)
Am J Physiol Cell Physiol 273, C1241-C1249
 |  Abstract »  |  Full Text »  |  PDF »

Specific Inhibition of Insulin-Like Growth Factor-1 and Insulin Receptor Tyrosine Kinase Activity and Biological Function by Tyrphostins.

M. Parrizas, A. Gazit, A. Levitzki, E. Wertheimer, and D. LeRoith (1997)
Endocrinology 138, 1427-1433
 |  Abstract »  |  Full Text »  |  PDF »

Hyaluronan Synthesis by Mouse Cumulus Cells Is Regulated by Interactions between Follicle-stimulating Hormone (or Epidermal Growth Factor) and a Soluble Oocyte Factor (or Transforming Growth Factor beta 1).

E. Tirone, C. D'Alessandris, V. C. Hascall, G. Siracusa, and A. Salustri (1997)
J. Biol. Chem. 272, 4787-4794
 |  Abstract »  |  Full Text »  |  PDF »

Hypothalamic Astrocytes Respond to Transforming Growth Factor-{alpha} with the Secretion of Neuroactive Substances That Stimulate the Release of Luteinizing Hormone-Releasing Hormone.

Y. J. Ma, K. Berg-von der Emde, F. Rage, W. C. Wetsel, and S. R. Ojeda (1997)
Endocrinology 138, 19-25
 |  Abstract »  |  Full Text »  |  PDF »

Differential Activation of Mitogen-activated Protein Kinase and S6 Kinase Signaling Pathways by 12-O-Tetradecanoylphorbol-13-acetate (TPA) and Insulin.

R. Seger, Y. Biener, R. Feinstein, T. Hanoch, A. Gazit, and Y. Zick (1995)
J. Biol. Chem. 270, 28325-28330
 |  Abstract »  |  Full Text »  |  PDF »

Phosphotyrosine-Dependent Targeting of Mitogen-Activated Protein Kinase in Differentiated Contractile Vascular Cells.

R. A. Khalil, C. B. Menice, C.-L. A. Wang, and K. G. Morgan (1995)
Circ. Res. 76, 1101-1108
 |  Abstract »  |  Full Text »

Inhibition of Autophagy and Multiple Steps in Asialoglycoprotein Endocytosis by Inhibitors of Tyrosine Protein Kinases (Tyrphostins).

I. Holen, P. E. Str, P. B. Gordon, M. Fengsrud, T. O. Berg, and P. O. Seglen (1995)
J. Biol. Chem. 270, 12823-12831
 |  Abstract »  |  Full Text »  |  PDF »

Tyrosine kinase inhibition: an approach to drug development.

A Levitzki and A Gazit (1995)
Science 267, 1782-1788
 |  Abstract »  |  PDF »

Prevention of lipopolysaccharide-induced lethal toxicity by tyrosine kinase inhibitors.

A Novogrodsky, A Vanichkin, M Patya, A Gazit, N Osherov, and A Levitzki (1994)
Science 264, 1319-1322
 |  Abstract »  |  PDF »

EGF abrogation-induced fusilli-form dysmorphogenesis of Meckel's cartilage during embryonic mouse mandibular morphogenesis in vitro.

L Shum, Y Sakakura, P Bringas, W Luo, M. Snead, M Mayo, C Crohin, S Millar, Z Werb, S Buckley, et al. (1993)
Development 118, 903-917
 |  Abstract »  |  PDF »

Growth factors and cancer.

S. Aaronson (1991)
Science 254, 1146-1153
 |  Abstract »  |  PDF »

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