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Science 4 November 1988:
Vol. 242. no. 4879, pp. 777 - 779
DOI: 10.1126/science.3187521
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Articles
Science, Vol 242, Issue 4879, 777-779
Copyright © 1988 by American Association for the Advancement of Science
Growth and transparency in the lens, an epithelial tissue, stimulated by pulses of PDGF
B Brewitt
and
JI Clark
Department of Biological Structure, University of Washington, School of Medicine, Seattle 98195.
The rat lens undergoes dramatic growth during early postnatal development. Lens weight increased by a factor of 23 in 26 days. Growth rate per day oscillated between 0 and 87 percent. A new culture system was designed to study the oscillations in growth during development. Lens growth and transparency in vitro required pulsatile delivery of platelet-derived growth factor (PDGF) in HL-1 serum-free medium. Continuous delivery of HL-1 medium with PDGF or pulsatile delivery of HL-1 medium without PDGF resulted in lens opacity and no growth. These results provide direct evidence that PDGF stimulates an epithelial tissue and that oscillations in growth occur during normal development of the rat lens.
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