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Science 4 November 1988:
Vol. 242. no. 4879, pp. 771 - 773
DOI: 10.1126/science.3142040
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Articles
Science, Vol 242, Issue 4879, 771-773
Copyright © 1988 by American Association for the Advancement of Science
Brain stem neurons in modified pathways for motor learning in the primate vestibulo-ocular reflex
SG Lisberger
and
TA Pavelko
Department of Physiology, University of California, San Francisco 94143.
The vestibulo-ocular reflex (VOR) stabilizes retinal images by generating smooth eye movements that are equal in amplitude and opposite in direction to head turns. Whenever image motion occurs persistently during head turns, the VOR undergoes motor learning; as a result image stability is gradually restored. A group of brain stem neurons that are in the modified pathways has now been described. The neurons express changes in firing in association with motor learning in the VOR and receive monosynaptic inhibition from the flocculus of the cerebellum. The changes in firing have an appropriate magnitude and are expressed at the correct latency to account for the altered VOR. The response properties of the neurons point to their brain stem vestibular inputs for further investigation of the site of motor learning.
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