Science 4 November 1988: Vol. 242. no. 4879, pp. 715 - 723 DOI: 10.1126/science.2903550

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Src Phosphorylation of {micro}-Receptor Is Responsible for the Receptor Switching from an Inhibitory to a Stimulatory Signal.

L. Zhang, H. Zhao, Y. Qiu, H. H. Loh, and P.-Y. Law (2009)
J. Biol. Chem. 284, 1990-2000
 |  Abstract »  |  Full Text »  |  PDF »

Neurobiological mechanisms for opponent motivational processes in addiction.

G. F Koob and M. Le Moal (2008)
Phil Trans R Soc B 363, 3113-3123
 |  Abstract »  |  Full Text »  |  PDF »

Syntaxin 1A Interaction with the Dopamine Transporter Promotes Amphetamine-Induced Dopamine Efflux.

F. Binda, C. Dipace, E. Bowton, S. D. Robertson, B. J. Lute, J. U. Fog, M. Zhang, N. Sen, R. J. Colbran, M. E. Gnegy, et al. (2008)
Mol. Pharmacol. 74, 1101-1108
 |  Abstract »  |  Full Text »  |  PDF »

Region-Specific Changes in the Subcellular Distribution of AMPA Receptor GluR1 Subunit in the Rat Ventral Tegmental Area after Acute or Chronic Morphine Administration.

D. A. Lane, A. A. Lessard, J. Chan, E. E. O. Colago, Y. Zhou, S. D. Schlussman, M. J. Kreek, and V. M. Pickel (2008)
J. Neurosci. 28, 9670-9681
 |  Abstract »  |  Full Text »  |  PDF »

Currents in Response to Rapid Concentration Jumps of Amphetamine Uncover Novel Aspects of Human Dopamine Transporter Function.

K. Erreger, C. Grewer, J. A. Javitch, and A. Galli (2008)
J. Neurosci. 28, 976-989
 |  Abstract »  |  Full Text »  |  PDF »

Combined effects of systemic alcohol and nicotine on dopamine release in the nucleus accumbens shell.

Y. Tizabi, L. Bai, R. L. Copeland JR., and R. E. Taylor (2007)
Alcohol Alcohol. 42, 413-416
 |  Abstract »  |  Full Text »  |  PDF »

Long-Term Upregulation of Protein Kinase A and Adenylate Cyclase Levels in Human Smokers.

B. T. Hope, D. Nagarkar, S. Leonard, and R. A. Wise (2007)
J. Neurosci. 27, 1964-1972
 |  Abstract »  |  Full Text »  |  PDF »

Addiction: A Disease of Learning and Memory.

S. E. Hyman (2007)
Focus 5, 220-228
 |  Abstract »  |  Full Text »  |  PDF »

New Medication Strategies for Comorbid Substance Use and Bipolar Affective Disorders.

T. R. Kosten and T. A. Kosten (2007)
Focus 5, 262-269
 |  Abstract »  |  Full Text »  |  PDF »

THE GLYCINE REUPTAKE INHIBITOR ORG 25935 DECREASES ETHANOL INTAKE AND PREFERENCE IN MALE WISTAR RATS.

A. MOLANDER, H. H. LIDO, E. LOF, M. ERICSON, and B. SODERPALM (2007)
Alcohol Alcohol. 42, 11-18
 |  Abstract »  |  Full Text »  |  PDF »

High levels of dopamine d2 receptors in unaffected members of alcoholic families: possible protective factors..

N. D. Volkow, G.-J. Wang, H. Begleiter, B. Porjesz, J. S. Fowler, F. Telang, C. Wong, Y. Ma, J. Logan, R. Goldstein, et al. (2006)
Arch Gen Psychiatry 63, 999-1008
 |  Abstract »  |  Full Text »  |  PDF »

Cocaine cues and dopamine in dorsal striatum: mechanism of craving in cocaine addiction..

N. D. Volkow, G.-J. Wang, F. Telang, J. S. Fowler, J. Logan, A.-R. Childress, M. Jayne, Y. Ma, and C. Wong (2006)
J. Neurosci. 26, 6583-6588
 |  Abstract »  |  Full Text »  |  PDF »

Short- and Long-Term Regulation of Adenylyl Cyclase Activity by {delta}-Opioid Receptor Are Mediated by G{alpha}i2 in Neuroblastoma N2A Cells.

L. Zhang, J. Tetrault, W. Wang, H. H. Loh, and P.-Y. Law (2006)
Mol. Pharmacol. 69, 1810-1819
 |  Abstract »  |  Full Text »  |  PDF »

Simultaneous dopamine and single-unit recordings reveal accumbens GABAergic responses: Implications for intracranial self-stimulation.

J. F. Cheer, M. L. A. V. Heien, P. A. Garris, R. M. Carelli, and R. M. Wightman (2005)
PNAS 102, 19150-19155
 |  Abstract »  |  Full Text »  |  PDF »

The "Ups and Downs" of Signaling Cascades in Addiction.

D. Ron and R. Jurd (2005)
Sci. STKE 2005, re14
 |  Abstract »  |  Full Text »  |  PDF »

Addiction: A Disease of Learning and Memory.

S. E. Hyman (2005)
Am J Psychiatry 162, 1414-1422
 |  Abstract »  |  Full Text »  |  PDF »

Akt Is Essential for Insulin Modulation of Amphetamine-Induced Human Dopamine Transporter Cell-Surface Redistribution.

B. G. Garcia, Y. Wei, J. A. Moron, R. Z. Lin, J. A. Javitch, and A. Galli (2005)
Mol. Pharmacol. 68, 102-109
 |  Abstract »  |  Full Text »  |  PDF »

CLINICAL PREDICTORS OF RESPONSE TO NALTREXONE IN ALCOHOLIC PATIENTS: WHO BENEFITS MOST FROM TREATMENT WITH NALTREXONE?.

G. RUBIO, G. PONCE, R. RODRIGUEZ-JIMENEZ, M. A. JIMENEZ-ARRIERO, J. HOENICKA, and T. PALOMO (2005)
Alcohol Alcohol. 40, 227-233
 |  Abstract »  |  Full Text »  |  PDF »

Activation of Orbital and Medial Prefrontal Cortex by Methylphenidate in Cocaine-Addicted Subjects But Not in Controls: Relevance to Addiction.

N. D. Volkow, G.-J. Wang, Y. Ma, J. S. Fowler, C. Wong, Y.-S. Ding, R. Hitzemann, J. M. Swanson, and P. Kalivas (2005)
J. Neurosci. 25, 3932-3939
 |  Abstract »  |  Full Text »  |  PDF »

Self-Administration of Cocaine-Opioid Combinations by Rhesus Monkeys: Evaluation of the Role of {micro} Receptor Efficacy Using Labor Supply Analysis.

J. K. Rowlett, J. S. Rodefer, and R. D. Spealman (2005)
J. Pharmacol. Exp. Ther. 312, 1289-1297
 |  Abstract »  |  Full Text »  |  PDF »

Mesolimbic Dopamine Super-Sensitivity in Melanin-Concentrating Hormone-1 Receptor-Deficient Mice.

D. G. Smith, E. T. Tzavara, J. Shaw, S. Luecke, M. Wade, R. Davis, C. Salhoff, G. G. Nomikos, and D. R. Gehlert (2005)
J. Neurosci. 25, 914-922
 |  Abstract »  |  Full Text »  |  PDF »

Executive Dysfunction in Cocaine Addiction: Evidence for Discordant Frontal, Cingulate, and Cerebellar Activity.

R. Hester and H. Garavan (2004)
J. Neurosci. 24, 11017-11022
 |  Abstract »  |  Full Text »  |  PDF »

Activation of the cGMP Pathway in Dopaminergic Structures Reduces Cocaine-Induced EGR-1 Expression and Locomotor Activity.

P. Jouvert, M.-O. Revel, A. Lazaris, D. Aunis, K. Langley, and J. Zwiller (2004)
J. Neurosci. 24, 10716-10725
 |  Abstract »  |  Full Text »  |  PDF »

Separate Neural Systems Value Immediate and Delayed Monetary Rewards.

S. M. McClure, D. I. Laibson, G. Loewenstein, and J. D. Cohen (2004)
Science 306, 503-507
 |  Abstract »  |  Full Text »  |  PDF »

Differences Between Accumbens Core and Shell Neurons Exhibiting Phasic Firing Patterns Related to Drug-Seeking Behavior During a Discriminative-Stimulus Task.

U. E. Ghitza, A. T. Fabbricatore, V. F. Prokopenko, and M. O. West (2004)
J Neurophysiol 92, 1608-1614
 |  Abstract »  |  Full Text »  |  PDF »

DiPOA ([8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic Acid), a Novel, Systemically Available, and Peripherally Restricted Mu Opioid Agonist with Antihyperalgesic Activity: I. In Vitro Pharmacological Characterization and Pharmacokinetic Properties.

K. J. Valenzano, W. Miller, Z. Chen, S. Shan, G. Crumley, S. F. Victory, E. Davies, J.-C. Huang, N. Allie, S. J. Nolan, et al. (2004)
J. Pharmacol. Exp. Ther. 310, 783-792
 |  Abstract »  |  Full Text »  |  PDF »

Cocaine-Like Discriminative Stimulus Effects of Heroin: Modulation by Selective Monoamine Transport Inhibitors.

J. K. Rowlett, D. M. Platt, and R. D. Spealman (2004)
J. Pharmacol. Exp. Ther. 310, 342-348
 |  Abstract »  |  Full Text »  |  PDF »

The Neural Substrates of Reward Processing in Humans: The Modern Role of fMRI.

S. M. McClure, M. K. York, and P. R. Montague (2004)
Neuroscientist 10, 260-268
 |  Abstract »  |  PDF »

Cocaine Self-Administration Produces a Progressive Involvement of Limbic, Association, and Sensorimotor Striatal Domains.

L. J. Porrino, D. Lyons, H. R. Smith, J. B. Daunais, and M. A. Nader (2004)
J. Neurosci. 24, 3554-3562
 |  Abstract »  |  Full Text »  |  PDF »

Amphetamine Regulation of Dopamine Transport: COMBINED MEASUREMENTS OF TRANSPORTER CURRENTS AND TRANSPORTER IMAGING SUPPORT THE ENDOCYTOSIS OF AN ACTIVE CARRIER.

K. M. Kahlig, J. A. Javitch, and A. Galli (2004)
J. Biol. Chem. 279, 8966-8975
 |  Abstract »  |  Full Text »  |  PDF »

Cholecystokinin activates CCKB receptors to excite cells and depress EPSCs in the rat rostral nucleus accumbens in vitro.

S. B. Kombian, K. V. V. Ananthalakshmi, S. S. Parvathy, and W. C. Matowe (2004)
J. Physiol. 555, 71-84
 |  Abstract »  |  Full Text »  |  PDF »

Intracranial Self-Administration of Ethanol within the Ventral Tegmental Area of Male Wistar Rats: Evidence for Involvement of Dopamine Neurons.

Z. A. Rodd, R. I. Melendez, R. L. Bell, K. A. Kuc, Y. Zhang, J. M. Murphy, and W. J. McBride (2004)
J. Neurosci. 24, 1050-1057
 |  Abstract »  |  Full Text »  |  PDF »

Role of serotonin in cocaine effects in mice with reduced dopamine transporter function.

Y. Mateo, E. A. Budygin, C. E. John, and S. R. Jones (2004)
PNAS 101, 372-377
 |  Abstract »  |  Full Text »  |  PDF »

RELATIONSHIP BETWEEN ETHANOL-INDUCED CHANGES IN BRAIN REGIONAL METABOLISM AND ITS MOTOR, BEHAVIOURAL AND COGNITIVE EFFECTS.

W. Zhu, N. D. Volkow, Y. Ma, J. S. Fowler, and G.-J. Wang (2004)
Alcohol Alcohol. 39, 53-58
 |  Abstract »  |  Full Text »  |  PDF »

Detection of Acute Tolerance to the Analgesic and Nonanalgesic Effects of Remifentanil Infusion in a Rabbit Model.

M. Hayashida, A. Fukunaga, and K. Hanaoka (2003)
Anesth. Analg. 97, 1347-1352
 |  Abstract »  |  Full Text »  |  PDF »

Cingulate Hypoactivity in Cocaine Users During a GO-NOGO Task as Revealed by Event-Related Functional Magnetic Resonance Imaging.

J. N. Kaufman, T. J. Ross, E. A. Stein, and H. Garavan (2003)
J. Neurosci. 23, 7839-7843
 |  Abstract »  |  Full Text »  |  PDF »

Persistent Cue-Evoked Activity of Accumbens Neurons after Prolonged Abstinence from Self-Administered Cocaine.

U. E. Ghitza, A. T. Fabbricatore, V. Prokopenko, A. P. Pawlak, and M. O. West (2003)
J. Neurosci. 23, 7239-7245
 |  Abstract »  |  Full Text »  |  PDF »

Low Level of Brain Dopamine D2 Receptors in Methamphetamine Abusers: Association With Metabolism in the Orbitofrontal Cortex.

N. D. Volkow, L. Chang, G.-J. Wang, J. S. Fowler, Y.-S. Ding, M. Sedler, J. Logan, D. Franceschi, J. Gatley, R. Hitzemann, et al. (2003)
Focus 1, 150-157
 |  Abstract »  |  Full Text »  |  PDF »

Substance P Depresses Excitatory Synaptic Transmission in the Nucleus Accumbens Through Dopaminergic and Purinergic Mechanisms.

S. B. Kombian, K. V. V. Ananthalakshmi, S. S. Parvathy, and W. C. Matowe (2003)
J Neurophysiol 89, 728-737
 |  Abstract »  |  Full Text »  |  PDF »

On the Embodiment of Addiction.

D. WEINBERG (2002)
Body Society 8, 1-19
 |  Abstract »  |  PDF »

Positive and Negative Motivation in Nucleus Accumbens Shell: Bivalent Rostrocaudal Gradients for GABA-Elicited Eating, Taste "Liking"/"Disliking" Reactions, Place Preference/Avoidance, and Fear.

S. M. Reynolds and K. C. Berridge (2002)
J. Neurosci. 22, 7308-7320
 |  Abstract »  |  Full Text »  |  PDF »

Neurobiology of Relapse to Heroin and Cocaine Seeking: A Review.

U. Shalev, J. W. Grimm, and Y. Shaham (2002)
Pharmacol. Rev. 54, 1-42
 |  Abstract »  |  Full Text »  |  PDF »

Tolerance and sensitization to the hypnotic effects of alcohol induced by chronic voluntary alcohol intake in rats.

S. Darbra, G. Prat, M. Pallares, and N. Ferre (2002)
J Psychopharmacol 16, 79-83
 |  Abstract »  |  PDF »

Low Level of Brain Dopamine D2 Receptors in Methamphetamine Abusers: Association With Metabolism in the Orbitofrontal Cortex.

N. D. Volkow, L. Chang, G.-J. Wang, J. S. Fowler, Y.-S. Ding, M. Sedler, J. Logan, D. Franceschi, J. Gatley, R. Hitzemann, et al. (2001)
Am J Psychiatry 158, 2015-2021
 |  Abstract »  |  Full Text »  |  PDF »

Metabolism of Vanoxerine, 1-[2-[bis(4-Fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl) Piperazine, by Human Cytochrome P450 Enzymes.

S. A. Cherstniakova, D. Bi, D. R. Fuller, J. Z. Mojsiak, J. M. Collins, and L. R. Cantilena (2001)
Drug Metab. Dispos. 29, 1216-1220
 |  Abstract »  |  Full Text »  |  PDF »

Cellular Depolarization of Neurons in the Locus Ceruleus Region of the Guinea Pig Associated with the Development of Tolerance to Opioids.

J.-Q. Kong, J. Meng, P. S. Biser, W. W. Fleming, and D. A. Taylor (2001)
J. Pharmacol. Exp. Ther. 298, 909-916
 |  Abstract »  |  Full Text »

Preferential Increases in Nucleus Accumbens Dopamine after Systemic Cocaine Administration Are Caused by Unique Characteristics of Dopamine Neurotransmission.

Q. Wu, M. E. A. Reith, M. J. Kuhar, F. I. Carroll, and P. A. Garris (2001)
J. Neurosci. 21, 6338-6347
 |  Abstract »  |  Full Text »  |  PDF »

Treatment Advances for Cocaine-Induced Ischemic Stroke: Focus on Dihydropyridine-Class Calcium Channel Antagonists.

B. A. Johnson, M. D. Devous Sr., P. Ruiz, and N. Ait-Daoud (2001)
Am J Psychiatry 158, 1191-1198
 |  Abstract »  |  Full Text »  |  PDF »

Blockade of D1 Dopamine Receptors in the Ventral Tegmental Area Decreases Cocaine Reward: Possible Role for Dendritically Released Dopamine.

R. Ranaldi and R. A. Wise (2001)
J. Neurosci. 21, 5841-5846
 |  Abstract »  |  Full Text »  |  PDF »

Network Synchrony in the Nucleus Accumbens In Vivo.

Y. Goto and P. O'Donnell (2001)
J. Neurosci. 21, 4498-4504
 |  Abstract »  |  Full Text »  |  PDF »

Electrophysiological Effects of Cocaethylene, Cocaine, and Ethanol on Dopaminergic Neurons of the Ventral Tegmental Area.

E. B. Bunney, S. B. Appel, and M. S. Brodie (2001)
J. Pharmacol. Exp. Ther. 297, 696-703
 |  Abstract »  |  Full Text »

GABAA Receptors Containing {alpha}5 Subunits in the CA1 and CA3 Hippocampal Fields Regulate Ethanol-Motivated Behaviors: An Extended Ethanol Reward Circuitry.

H. L. June, S. C. Harvey, K. L. Foster, P. F. McKay, R. Cummings, M. Garcia, D. Mason, C. Grey, S. McCane, L. S. Williams, et al. (2001)
J. Neurosci. 21, 2166-2177
 |  Abstract »  |  Full Text »  |  PDF »

Addiction and the brain: the role of neurotransmitters in the cause and treatment of drug dependence.

D. M. Tomkins and E. M. Sellers (2001)
Can. Med. Assoc. J. 164, 817-821
 |  Abstract »  |  Full Text »  |  PDF »

Cellular and Synaptic Adaptations Mediating Opioid Dependence.

J. T. Williams, M. J. Christie, and O. Manzoni (2001)
Physiol Rev 81, 299-343
 |  Abstract »  |  Full Text »  |  PDF »

EFFECTS OF ETHANOL ON EXTRACELLULAR AMINO ACID LEVELS IN HIGH-AND LOW-ALCOHOL SENSITIVE RATS: A MICRODIALYSIS STUDY.

A. Dahchour, A. Hoffman, R. Deitrich, and P. de Witte (2000)
Alcohol Alcohol. 35, 548-553
 |  Abstract »  |  Full Text »  |  PDF »

Effect of Temperature on Dopamine Transporter Function and Intracellular Accumulation of Methamphetamine: Implications for Methamphetamine-Induced Dopaminergic Neurotoxicity.

T. Xie, U. D. McCann, S. Kim, J. Yuan, and G. A. Ricaurte (2000)
J. Neurosci. 20, 7838-7845
 |  Abstract »  |  Full Text »  |  PDF »

Neurobiological Correlates of Individual Differences in Novelty-Seeking Behavior in the Rat: Differential Expression of Stress-Related Molecules.

M. Kabbaj, D. P. Devine, V. R. Savage, and H. Akil (2000)
J. Neurosci. 20, 6983-6988
 |  Abstract »  |  Full Text »  |  PDF »

Elevated Central Serotonin Transporter Binding Availability in Acutely Abstinent Cocaine-Dependent Patients.

L. K. Jacobsen, J. K. Staley, R. T. Malison, S. S. Zoghbi, J. P. Seibyl, T. R. Kosten, and R. B. Innis (2000)
Am J Psychiatry 157, 1134-1140
 |  Abstract »  |  Full Text »

Acute Tolerance to Continuously Infused Alfentanil: The Role of Cholecystokinin and N-Methyl-D-Aspartate-Nitric Oxide Systems.

I. Kissin, C. A. Bright, and E. L. Bradley Jr. (2000)
Anesth. Analg. 91, 110-116
 |  Abstract »  |  Full Text »  |  PDF »

Cocaine Potentiates Ethanol-Induced Excitation of Dopaminergic Reward Neurons in the Ventral Tegmental Area.

E. B. Bunney, S. B. Appel, and M. S. Brodie (2000)
J. Pharmacol. Exp. Ther. 293, 383-389
 |  Abstract »  |  Full Text »

Ethanol Enhances gamma -Aminobutyric Acid Responses in a Subpopulation of Nucleus Accumbens Neurons: Role of Metabotropic Glutamate Receptors.

Z. Nie, S. G. Madamba, and G. R. Siggins (2000)
J. Pharmacol. Exp. Ther. 293, 654-661
 |  Abstract »  |  Full Text »

Hedonistic homeostatic dysregulation in patients with Parkinson's disease on dopamine replacement therapies.

G Giovannoni, J D O'Sullivan, K Turner, A J Manson, and A J L Lees (2000)
J. Neurol. Neurosurg. Psychiatry 68, 423-428
 |  Abstract »  |  Full Text »  |  PDF »

Amphetamine Withdrawal Alters Bistable States and Cellular Coupling in Rat Prefrontal Cortex and Nucleus Accumbens Neurons Recorded In Vivo.

S.-P. Onn and A. A. Grace (2000)
J. Neurosci. 20, 2332-2345
 |  Abstract »  |  Full Text »  |  PDF »

Addiction, a Disease of Compulsion and Drive: Involvement of the Orbitofrontal Cortex.

N. D. Volkow and J. S. Fowler (2000)
Cereb Cortex 10, 318-325
 |  Abstract »  |  Full Text »  |  PDF »

Orbital and Medial Prefrontal Cortex and Psychostimulant Abuse: Studies in Animal Models.

L. J. Porrino and D. Lyons (2000)
Cereb Cortex 10, 326-333
 |  Abstract »  |  Full Text »  |  PDF »

Orbitofrontal Cortex and Human Drug Abuse: Functional Imaging.

E. D. London, M. Ernst, S. Grant, K. Bonson, and A. Weinstein (2000)
Cereb Cortex 10, 334-342
 |  Abstract »  |  Full Text »  |  PDF »

Attenuation of the Euphoric Effects of Cocaine by the Dopamine D1/D5 Antagonist Ecopipam (SCH 39166).

M. K. Romach, P. Glue, K. Kampman, H. L. Kaplan, G. R. Somer, S. Poole, L. Clarke, V. Coffin, J. Cornish, C. P. O'Brien, et al. (1999)
Arch Gen Psychiatry 56, 1101-1106
 |  Abstract »  |  Full Text »  |  PDF »

The Biology of pro-Thyrotropin-Releasing Hormone-Derived Peptides.

E. A. Nillni and K. A. Sevarino (1999)
Endocr. Rev. 20, 599-648
 |  Abstract »  |  Full Text »

Effects of the Long-Acting Monoamine Reuptake Inhibitor Indatraline on Cocaine Self-Administration in Rhesus Monkeys.

S. S. Negus, M. R. Brandt, and N. K. Mello (1999)
J. Pharmacol. Exp. Ther. 291, 60-69
 |  Abstract »  |  Full Text »

Effects of Various Serotonin Agonists, Antagonists, and Uptake Inhibitors on the Discriminative Stimulus Effects of Methamphetamine in Rats.

P. Munzar, M. D. Laufert, S. W. Kutkat, J. Nováková, and S. R. Goldberg (1999)
J. Pharmacol. Exp. Ther. 291, 239-250
 |  Abstract »  |  Full Text »

Reinforcing Effects of Psychostimulants in Humans Are Associated with Increases in Brain Dopamine and Occupancy of D2 Receptors.

N. D. Volkow, G.-J. Wang, J. S. Fowler, J. Logan, S. J. Gatley, C. Wong, R. Hitzemann, and N. R. Pappas (1999)
J. Pharmacol. Exp. Ther. 291, 409-415
 |  Abstract »  |  Full Text »

Discriminative Stimulus Effects of Morphine in Squirrel Monkeys: Stimulants, Opioids, and Stimulant-Opioid Combinations.

D. M. Platt, D. M. Grech, J. K. Rowlett, and R. D. Spealman (1999)
J. Pharmacol. Exp. Ther. 290, 1092-1100
 |  Abstract »  |  Full Text »

Baclofen Inhibits Heroin Self-Administration Behavior and Mesolimbic Dopamine Release.

Z.-X. Xi and E. A. Stein (1999)
J. Pharmacol. Exp. Ther. 290, 1369-1374
 |  Abstract »  |  Full Text »

Total Neurochemical Lesion of Noradrenergic Neurons of the Locus Ceruleus Does Not Alter Either Naloxone-Precipitated or Spontaneous Opiate Withdrawal nor Does It Influence Ability of Clonidine To Reverse Opiate Withdrawal.

S. Caillé, E. F. Espejo, J.-P. Reneric, M. Cador, G. F. Koob, and L. Stinus (1999)
J. Pharmacol. Exp. Ther. 290, 881-892
 |  Abstract »  |  Full Text »

Imaging studies on the role of dopamine in cocaine reinforcement and addiction in humans.

N. D. Volkow, J. S. Fowler, and G.-J. Wang (1999)
J Psychopharmacol 13, 337-345
 |  Abstract »  |  PDF »

Association of Methylphenidate-Induced Craving With Changes in Right Striato-orbitofrontal Metabolism in Cocaine Abusers: Implications in Addiction.

N. D. Volkow, G.-J. Wang, J. S. Fowler, R. Hitzemann, B. Angrist, S. J. Gatley, J. Logan, Y.-S. Ding, and N. Pappas (1999)
Am J Psychiatry 156, 19-26
 |  Abstract »  |  Full Text »

Synergistic Elevations in Nucleus Accumbens Extracellular Dopamine Concentrations during Self-Administration of Cocaine/Heroin Combinations (Speedball) in Rats.

S. E. Hemby, C. Co, S. I. Dworkin, and J. E. Smith (1999)
J. Pharmacol. Exp. Ther. 288, 274-280
 |  Abstract »  |  Full Text »

Serotonin1B Receptor Stimulation Enhances Cocaine Reinforcement.

L. H. Parsons, F. Weiss, and G. F. Koob (1998)
J. Neurosci. 18, 10078-10089
 |  Abstract »  |  Full Text »  |  PDF »

Co-occurrence of Abuse of Different Drugs in Men: The Role of Drug-Specific and Shared Vulnerabilities.

M. T. Tsuang, M. J. Lyons, J. M. Meyer, T. Doyle, S. A. Eisen, J. Goldberg, W. True, N. Lin, R. Toomey, and L. Eaves (1998)
Arch Gen Psychiatry 55, 967-972
 |  Abstract »  |  Full Text »  |  PDF »

Imidazenil, a Positive Allosteric GABAA Receptor Modulator, Inhibits the Effects of Cocaine on Locomotor Activity and Extracellular Dopamine in the Nucleus Accumbens Shell Without Tolerance Liability.

M. Giorgetti, J. I. Javaid, J. M. Davis, E. Costa, A. Guidotti, S. B. Appel, and M. S. Brodie (1998)
J. Pharmacol. Exp. Ther. 287, 58-66
 |  Abstract »  |  Full Text »

Dopamine Transporter Occupancies in the Human Brain Induced by Therapeutic Doses of Oral Methylphenidate.

N. D. Volkow, Gene.-J. Wang, J. S. Fowler, S. J. Gatley, J. Logan, Y.-S. Ding, R. Hitzemann, and N. Pappas (1998)
Am J Psychiatry 155, 1325-1331
 |  Abstract »  |  Full Text »

Inwardly Rectifying Potassium (IRK) Currents Are Correlated with IRK Subunit Expression in Rat Nucleus Accumbens Medium Spiny Neurons.

P. G. Mermelstein, W.-J. Song, T. Tkatch, Z. Yan, and D. J. Surmeier (1998)
J. Neurosci. 18, 6650-6661
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Increased Opioid Inhibition of GABA Release in Nucleus Accumbens during Morphine Withdrawal.

B. Chieng and J. T. Williams (1998)
J. Neurosci. 18, 7033-7039
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Psychiatry and Cigarettes.

A. H. Glassman (1998)
Arch Gen Psychiatry 55, 692-693
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Dopamine-dependent responses to morphine depend on glucocorticoid receptors.

M. Marinelli, B. Aouizerate, M. Barrot, M. Le Moal, and P. V. Piazza (1998)
PNAS 95, 7742-7747
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Elevated Striatal Dopamine Transporters During Acute Cocaine Abstinence as Measured by [123I]ß-CIT SPECT.

R. T. Malison, S. E. Best, C. H. van Dyck, E. F. McCance, E. A. Wallace, M. Laruelle, R. M. Baldwin, J. P. Seibyl, L. H. Price, T. R. Kosten, et al. (1998)
Am J Psychiatry 155, 832-834
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Discriminative Stimulus Effects of a Cocaine/Heroin "Speedball" Combination in Rhesus Monkeys.

S. S. Negus, M. B. Gatch, and N. K. Mello (1998)
J. Pharmacol. Exp. Ther. 285, 1123-1136
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Preferential localization of self-stimulation sites in striosomes/patches in the rat striatum.

N. M. White and N. Hiroi (1998)
PNAS 95, 6486-6491
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Intake of High-Fat Food Is Selectively Enhanced by Mu Opioid Receptor Stimulation within the Nucleus Accumbens.

M. Zhang, B. A. Gosnell, and A. E. Kelley (1998)
J. Pharmacol. Exp. Ther. 285, 908-914
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Profound neuronal plasticity in response to inactivation of the dopamine transporter.

S. R. Jones, R. R. Gainetdinov, M. Jaber, B. Giros, R. M. Wightman, and M. G. Caron (1998)
PNAS 95, 4029-4034
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Mechanisms of Amphetamine Action Revealed in Mice Lacking the Dopamine Transporter.

S. R. Jones, R. R. Gainetdinov, R. M. Wightman, and M. G. Caron (1998)
J. Neurosci. 18, 1979-1986
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Enhanced Sensitivity to Benzodiazepines in Active Cocaine-Abusing Subjects: A PET Study.

N. D. Volkow, G.-J. Wang, J. S. Fowler, R. Hitzemann, S. J. Gatley, S. S. Dewey, and N. Pappas (1998)
Am J Psychiatry 155, 200-206
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Substance dependence as a compulsive behavior.

G. F. Koob, M. Rocio, A. Carrera, L. H. Gold, C. J. Heyser, C. Maldonado-Irizarry, A. Markou, L. H. Parsons, A. J. Roberts, G. Schulteis, et al. (1998)
J Psychopharmacol 12, 39-48
 |  Abstract »  |  PDF »

Whole-Cell Plasticity in Cocaine Withdrawal: Reduced Sodium Currents in Nucleus Accumbens Neurons.

X.-F. Zhang, X.-T. Hu, and F. J. White (1998)
J. Neurosci. 18, 488-498
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Modafinil Induces Wakefulness Without Intensifying Motor Activity or Subsequent Rebound Hypersomnolence in the Rat.

D. M. Edgar and W. F. Seidel (1997)
J. Pharmacol. Exp. Ther. 283, 757-769
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Persistent Structural Modifications in Nucleus Accumbens and Prefrontal Cortex Neurons Produced by Previous Experience with Amphetamine.

T. E. Robinson and B. Kolb (1997)
J. Neurosci. 17, 8491-8497
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Role of Dopamine D1 and D2 Receptors in the Nucleus Accumbens in Mediating Reward.

S. Ikemoto, B. S. Glazier, J. M. Murphy, and W. J. McBride (1997)
J. Neurosci. 17, 8580-8587
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Systemic Morphine-Induced Fos Protein in the Rat Striatum and Nucleus Accumbens Is Regulated by µ Opioid Receptors in the Substantia Nigra and Ventral Tegmental Area.

B. Bontempi and F. R. Sharp (1997)
J. Neurosci. 17, 8596-8612
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Drug Abuse: Hedonic Homeostatic Dysregulation.

G. F. Koob and M. L. Moal (1997)
Science 278, 52-58
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