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Science 4 November 1988:
Vol. 242. no. 4879, pp. 692 - 699
DOI: 10.1126/science.3055291

Articles

Science, Vol 242, Issue 4879, 692-699
Copyright © 1988 by American Association for the Advancement of Science


articles

Axon guidance and the patterning of neuronal projections in vertebrates

J Dodd and TM Jessell

Department of Physiology and Cellular Biophysics, Columbia University, New York, NY 10032.

Over the past decade, new insights have been obtained into the cellular strategies and molecular mechanisms that guide axons to their targets in the developing vertebrate nervous system. Axons select pathways by recognizing specific cues in their environment. These cues include cell surface and extracellular matrix molecules that mediate cell and substrate adhesion and axon fasciculation, molecules with contact-dependent inhibitory properties, and diffusible tropic factors. Several guidance cues may operate in a coordinated way to generate the distinct axonal trajectories of individual neurons.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)