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Science 28 October 1988:
Vol. 242. no. 4878, pp. 569 - 571
DOI: 10.1126/science.2902689
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Articles

Science, Vol 242, Issue 4878, 569-571
Copyright © 1988 by American Association for the Advancement of Science

articles

In vivo administration of anti-CD3 prevents malignant progressor tumor growth

JD Ellenhorn, R Hirsch, H Schreiber, and JA Bluestone

University of Chicago, IL 60637.

Malignant progressor tumors are only weakly immunogenic and can evade host recognition and rejection. One approach to therapy involves activation of the host antitumor cellular effector mechanisms. Since monoclonal antibodies to CD3 (anti-CD3) can activate T cells in vitro, an attempt was made to determine if tumor immunity could be achieved by the administration of anti-CD3 in vivo. T lymphocytes from mice injected with anti-CD3 showed increased interleukin-2 receptor (IL-2R) expression, increased proliferation to recombinant IL-2 (rIL-2), and enhanced reactivity in both an allogeneic mixed lymphocyte reaction and a mixed lymphocyte tumor culture. Malignant tumor growth in treated mice was also examined. The anti-CD3 treatment prevented tumor outgrowth that would have killed untreated animals and also stimulated an in vivo response against a malignant progressor tumor providing lasting tumor immunity.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Int. Immunol. 17, 513-522
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A Single-Chain Class II MHC-IgG3 Fusion Protein Inhibits Autoimmune Arthritis by Induction of Antigen-Specific Hyporesponsiveness.
L. Zuo, C. M. Cullen, M. L. DeLay, S. Thornton, L. K. Myers, E. F. Rosloniec, G. P. Boivin, and R. Hirsch (2002)
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Phase I Evaluation of Humanized OKT3: Toxicity and Immunomodulatory Effects of hOKT3{{gamma}}4.
J. Richards, J. Auger, D. Peace, D. Gale, J. Michel, A. Koons, T. Haverty, R. Zivin, L. Jolliffe, and J. A. Bluestone (1999)
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A lymphocyte-activating monoclonal antibody induces regression of human tumors in severe combined immunodeficient mice.
B. Hardy, R. Kovjazin, A. Raiter, N. Ganor, and A. Novogrodsky (1997)
PNAS 94, 5756-5760
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Hematopoietic Changes Induced by a Single Injection of Anti-CD3 Monoclonal Antibody into Normal Mice.
E. Schneider, V. Salaün, A. Ben Amor, and M. Dy (1997)
Stem Cells 15, 154-160
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CD3-mediated activation of tumor-reactive lymphocytes from patients with advanced cancer.
I. Hellstrom, J. A. Ledbetter, N. Scholler, Y. Yang, Z. Ye, G. Goodman, J. Pullman, M. Hayden-Ledbetter, and K. E. Hellstrom (2001)
PNAS 98, 6783-6788
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)