Science 28 October 1988: Vol. 242. no. 4878, pp. 540 - 546 DOI: 10.1126/science.3140380

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Articles

Discovering NF-{kappa}B.

D. Baltimore (2009)
Cold Spring Harb. Perspect. Biol. 1, a000026
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Suppression of LPS-Induced TNF-{alpha} Production in Macrophages by cAMP Is Mediated by PKA-AKAP95-p105.

E. A. Wall, J. R. Zavzavadjian, M. S. Chang, B. Randhawa, X. Zhu, R. C. Hsueh, J. Liu, A. Driver, X. R. Bao, P. C. Sternweis, et al. (2009)
Science Signaling 2, ra28
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Kinetic control of negative feedback regulators of NF-{kappa}B/RelA determines their pathogen- and cytokine-receptor signaling specificity.

V. F.-S. Shih, J. D. Kearns, S. Basak, O. V. Savinova, G. Ghosh, and A. Hoffmann (2009)
PNAS 106, 9619-9624
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GCN5 is a required cofactor for a ubiquitin ligase that targets NF-{kappa}B/RelA.

X. Mao, N. Gluck, D. Li, G. N. Maine, H. Li, I. W. Zaidi, A. Repaka, M. W. Mayo, and E. Burstein (2009)
Genes & Dev. 23, 849-861
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New Mechanism of Rosiglitazone to Reduce Neointimal Hyperplasia: Activation of Glycogen Synthase Kinase-3{beta} Followed by Inhibition of MMP-9.

C.-S. Lee, Y.-W. Kwon, H.-M. Yang, S.-H. Kim, T.-Y. Kim, J. Hur, K.-W. Park, H.-J. Cho, H.-J. Kang, Y.-B. Park, et al. (2009)
Arterioscler. Thromb. Vasc. Biol. 29, 472-479
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Synergistic Induction of Inflammation by Bacterial Products Lipopolysaccharide and fMLP: An Important Microbial Pathogenic Mechanism.

L.-Y. Chen, W. W. Pan, M. Chen, J.-D. Li, W. Liu, G. Chen, S. Huang, T. J. Papadimos, and Z. K. Pan (2009)
J. Immunol. 182, 2518-2524
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Interleukin-1 Regulates the Expression of Sphingosine Kinase 1 in Glioblastoma Cells.

B. S. Paugh, L. Bryan, S. W. Paugh, K. M. Wilczynska, S. M. Alvarez, S. K. Singh, D. Kapitonov, H. Rokita, S. Wright, I. Griswold-Prenner, et al. (2009)
J. Biol. Chem. 284, 3408-3417
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Diarctigenin, a Lignan Constituent from Arctium lappa, Down-Regulated Zymosan-Induced Transcription of Inflammatory Genes through Suppression of DNA Binding Ability of Nuclear Factor-{kappa}B in Macrophages.

B. H. Kim, S. S. Hong, S. W. Kwon, H. Y. Lee, H. Sung, I.-J. Lee, B. Y. Hwang, S. Song, C.-K. Lee, D. Chung, et al. (2008)
J. Pharmacol. Exp. Ther. 327, 393-401
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Forkhead Transcription Factors (FoxOs) Promote Apoptosis of Insulin-Resistant Macrophages During Cholesterol-Induced Endoplasmic Reticulum Stress.

T. Senokuchi, C.-P. Liang, T. A. Seimon, S. Han, M. Matsumoto, A. S. Banks, J.-H. Paik, R. A. DePinho, D. Accili, I. Tabas, et al. (2008)
Diabetes 57, 2967-2976
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Hydrogen Peroxide Prolongs Nuclear Localization of NF-{kappa}B in Activated Cells by Suppressing Negative Regulatory Mechanisms.

K. Enesa, K. Ito, L. A. Luong, I. Thorbjornsen, C. Phua, Y. To, J. Dean, D. O. Haskard, J. Boyle, I. Adcock, et al. (2008)
J. Biol. Chem. 283, 18582-18590
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Depletion of {beta}-Arrestin-2 Promotes Tumor Growth and Angiogenesis in a Murine Model of Lung Cancer.

S. K. Raghuwanshi, M. W. Nasser, X. Chen, R. M. Strieter, and R. M. Richardson (2008)
J. Immunol. 180, 5699-5706
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Benzoxathiole Derivative Blocks Lipopolysaccharide-Induced Nuclear Factor-{kappa}B Activation and Nuclear Factor-{kappa}B-Regulated Gene Transcription through Inactivating Inhibitory {kappa}B Kinase {beta}.

B. H. Kim, E. Roh, H. Y. Lee, I.-J. Lee, B. Ahn, S.-H. Jung, H. Lee, S.-B. Han, and Y. Kim (2008)
Mol. Pharmacol. 73, 1309-1318
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GPR30 Contributes to Estrogen-Induced Thymic Atrophy.

C. Wang, B. Dehghani, I. J. Magrisso, E. A. Rick, E. Bonhomme, D. B. Cody, L. A. Elenich, S. Subramanian, S. J. Murphy, M. J. Kelly, et al. (2008)
Mol. Endocrinol. 22, 636-648
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Transglutaminase Type II Is Involved in the Pathogenesis of Endotoxic Shock.

L. Falasca, M. G. Farrace, A. Rinaldi, L. Tuosto, G. Melino, and M. Piacentini (2008)
J. Immunol. 180, 2616-2624
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EGF regulates plasminogen activator inhibitor-1 (PAI-1) by a pathway involving c-Src, PKC{delta}, and sphingosine kinase 1 in glioblastoma cells.

B. S. Paugh, S. W. Paugh, L. Bryan, D. Kapitonov, K. M. Wilczynska, S. M. Gopalan, H. Rokita, S. Milstien, S. Spiegel, and T. Kordula (2008)
FASEB J 22, 455-465
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Combined Prognostic Value of Both RelA and I{kappa}B-{alpha} Expression in Human Non Small Cell Lung Cancer.

D. Zhang, X. Jin, F. Wang, S. Wang, C. Deng, Z. Gao, and C. Guo (2007)
Ann. Surg. Oncol. 14, 3581-3592
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Hormonal control of the renal immune response and antibacterial host defense by arginine vasopressin.

C. Chassin, M. W. Hornef, M. Bens, M. Lotz, J.-M. Goujon, S. Vimont, G. Arlet, A. Hertig, E. Rondeau, and A. Vandewalle (2007)
J. Exp. Med. 204, 2837-2852
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Torque Teno Virus (SANBAN Isolate) ORF2 Protein Suppresses NF-{kappa}B Pathways via Interaction with I{kappa}B Kinases.

H. Zheng, L. Ye, X. Fang, B. Li, Y. Wang, X. Xiang, L. Kong, W. Wang, Y. Zeng, L. Ye, et al. (2007)
J. Virol. 81, 11917-11924
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Id-1 activation of PI3K/Akt/NF{kappa}B signaling pathway and its significance in promoting survival of esophageal cancer cells.

B. Li, P. Y. Cheung, X. Wang, S. W. Tsao, M. T. Ling, Y. C. Wong, and A. L.M. Cheung (2007)
Carcinogenesis 28, 2313-2320
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Elevated NF-{kappa}B responses and FLIP levels in leukemic but not normal lymphocytes: reduction by salicylate allows TNF-induced apoptosis.

C. Rae, S. Langa, S. J. Tucker, and D. J. MacEwan (2007)
PNAS 104, 12790-12795
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The Induction of Growth Arrest DNA Damage-Inducible Gene 45 {beta} in Human Hepatoma Cell Lines by S-Adenosylmethionine.

W. Qiu, B. Zhou, P. G. Chu, F. Luh, and Y. Yen (2007)
Am. J. Pathol. 171, 287-296
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Atiprimod inhibits the growth of mantle cell lymphoma in vitro and in vivo and induces apoptosis via activating the mitochondrial pathways.

M. Wang, L. Zhang, X. Han, J. Yang, J. Qian, S. Hong, F. Samaniego, J. Romaguera, and Q. Yi (2007)
Blood 109, 5455-5462
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Hydrogen sulfide induces the synthesis of proinflammatory cytokines in human monocyte cell line U937 via the ERK-NF-{kappa}B pathway.

L. Zhi, A. D. Ang, H. Zhang, P. K. Moore, and M. Bhatia (2007)
J. Leukoc. Biol. 81, 1322-1332
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The differential expression of corticosteroid receptor isoforms in corticosteroid-resistant and -sensitive patients with rheumatoid arthritis.

D. L. Kozaci, Y. Chernajovsky, and I. C. Chikanza (2007)
Rheumatology 46, 579-585
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A Transgenic Model Reveals Important Roles for the NF-{kappa}B Alternative Pathway (p100/p52) in Mammary Development and Links to Tumorigenesis.

L. Connelly, C. Robinson-Benion, M. Chont, L. Saint-Jean, H. Li, V. V. Polosukhin, T. S. Blackwell, and F. E. Yull (2007)
J. Biol. Chem. 282, 10028-10035
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Keratinocyte Growth Factor/Fibroblast Growth Factor-7-regulated Cell Migration and Invasion through Activation of NF-{kappa}B Transcription Factors.

J. Niu, Z. Chang, B. Peng, Q. Xia, W. Lu, P. Huang, M.-S. Tsao, and P. J. Chiao (2007)
J. Biol. Chem. 282, 6001-6011
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Novel Genomic Effects of Glucocorticoids in Epidermal Keratinocytes: INHIBITION OF APOPTOSIS, INTERFERON-{gamma} PATHWAY, AND WOUND HEALING ALONG WITH PROMOTION OF TERMINAL DIFFERENTIATION.

O. Stojadinovic, B. Lee, C. Vouthounis, S. Vukelic, I. Pastar, M. Blumenberg, H. Brem, and M. Tomic-Canic (2007)
J. Biol. Chem. 282, 4021-4034
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I{kappa}B Kinase Subunits {alpha} and {gamma} Are Required for Activation of NF-{kappa}B and Induction of Apoptosis by Mammalian Reovirus.

M. W. Hansberger, J. A. Campbell, P. Danthi, P. Arrate, K. N. Pennington, K. B. Marcu, D. W. Ballard, and T. S. Dermody (2007)
J. Virol. 81, 1360-1371
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Inducible expression of the proallergic cytokine thymic stromal lymphopoietin in airway epithelial cells is controlled by NF{kappa}B.

H.-C. Lee and S. F. Ziegler (2007)
PNAS 104, 914-919
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Regions of I{kappa}B{alpha} that are critical for its inhibition of NF-{kappa}B{middle dot}DNA interaction fold upon binding to NF-{kappa}B.

S. M. E. Truhlar, J. W. Torpey, and E. A. Komives (2006)
PNAS 103, 18951-18956
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A Novel Mechanism of Tissue Inhibitor of Metalloproteinases-1 Activation by Interleukin-1 in Primary Human Astrocytes.

K. M. Wilczynska, S. M. Gopalan, M. Bugno, A. Kasza, B. S. Konik, L. Bryan, S. Wright, I. Griswold-Prenner, and T. Kordula (2006)
J. Biol. Chem. 281, 34955-34964
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Renal Collecting Duct Epithelial Cells React to Pyelonephritis-Associated Escherichia coli by Activating Distinct TLR4-Dependent and -Independent Inflammatory Pathways.

C. Chassin, J.-M. Goujon, S. Darche, L. du Merle, M. Bens, F. Cluzeaud, C. Werts, E. Ogier-Denis, C. Le Bouguenec, D. Buzoni-Gatel, et al. (2006)
J. Immunol. 177, 4773-4784
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Interleukin-1-induced NF-{kappa}B recruitment to the oxytocin receptor gene inhibits RNA polymerase II-promoter interactions in cultured human myometrial cells.

M. S. Soloff, M. G. Izban, D. L. Cook Jr, Y.-J. Jeng, and R. C. Mifflin (2006)
Mol. Hum. Reprod. 12, 619-624
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Overexpression of Tissue Transglutaminase Leads to Constitutive Activation of Nuclear Factor-{kappa}B in Cancer Cells: Delineation of a Novel Pathway..

A. P. Mann, A. Verma, G. Sethi, B. Manavathi, H. Wang, J. Y. Fok, A. B. Kunnumakkara, R. Kumar, B. B. Aggarwal, and K. Mehta (2006)
Cancer Res. 66, 8788-8795
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Characterization of the Nuclear Factor-{kappa}B Responsiveness of the Human dio2 Gene.

A. Zeold, M. Doleschall, M. C. Haffner, L. P. Capelo, J. Menyhert, Z. Liposits, W. S. da Silva, A. C. Bianco, I. Kacskovics, C. Fekete, et al. (2006)
Endocrinology 147, 4419-4429
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Nuclear Factor-1-X Regulates Astrocyte-specific Expression of the {alpha}1-Antichymotrypsin and Glial Fibrillary Acidic Protein Genes.

S. M. Gopalan, K. M. Wilczynska, B. S. Konik, L. Bryan, and T. Kordula (2006)
J. Biol. Chem. 281, 13126-13133
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Persistent Interleukin-1beta Signaling Causes Long Term Activation of NF{kappa}B in a Promoter-specific Manner in Human Glial Cells.

B. D. Griffin and P. N. Moynagh (2006)
J. Biol. Chem. 281, 10316-10326
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3H-1,2-Dithiole-3-thione Targets Nuclear Factor {kappa}B to Block Expression of Inducible Nitric-Oxide Synthase, Prevents Hypotension, and Improves Survival in Endotoxemic Rats.

A. R. Karuri, Y. Huang, S. Bodreddigari, C. H. Sutter, B. D. Roebuck, T. W. Kensler, and T. R. Sutter (2006)
J. Pharmacol. Exp. Ther. 317, 61-67
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A Molecular Mechanism for the Anti-Inflammatory Effect of Taurine-Conjugated 5-Aminosalicylic Acid in Inflamed Colon.

H. Kim, H. Jeon, H. Kong, Y. Yang, B. Choi, Y. M. Kim, L. Neckers, and Y. Jung (2006)
Mol. Pharmacol. 69, 1405-1412
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Sustained Activation of Phosphatidylinositol 3-Kinase/Akt/Nuclear Factor {kappa}B Signaling Mediates G Protein-coupled {delta}-Opioid Receptor Gene Expression.

Y. L. Chen, P.-Y. Law, and H. H. Loh (2006)
J. Biol. Chem. 281, 3067-3074
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Inhibition of Human Immunodeficiency Virus Type 1 Replication in Latently Infected Cells by a Novel I{kappa}B Kinase Inhibitor.

A. F. B. Victoriano, K. Asamitsu, Y. Hibi, K. Imai, N. G. Barzaga, and T. Okamoto (2006)
Antimicrob. Agents Chemother. 50, 547-555
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Astrocyte-specific Expression of the {alpha}1-Antichymotrypsin and Glial Fibrillary Acidic Protein Genes Requires Activator Protein-1.

S. M. Gopalan, K. M. Wilczynska, B. S. Konik, L. Bryan, and T. Kordula (2006)
J. Biol. Chem. 281, 1956-1963
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Escherichia coli K1 inhibits proinflammatory cytokine induction in monocytes by preventing NF-{kappa}B activation.

S. K. Selvaraj and N. V. Prasadarao (2005)
J. Leukoc. Biol. 78, 544-554
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Breast Cancer Metastasis Suppressor 1 Inhibits Gene Expression by Targeting Nuclear Factor-{kappa}B Activity.

M. Cicek, R. Fukuyama, D. R. Welch, N. Sizemore, and G. Casey (2005)
Cancer Res. 65, 3586-3595
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Role Played by Hypothalamic Nuclear Factor-{kappa}B in Alcohol-Mediated Activation of the Rat Hypothalamic-Pituitary-Adrenal Axis.

S. Lee and C. Rivier (2005)
Endocrinology 146, 2006-2014
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Requirement of Thyrotropin-Dependent Complex Formation of Protein Kinase A Catalytic Subunit with Inhibitor of {kappa}B Proteins for Activation of p65 Nuclear Factor-{kappa}B by Tumor Necrosis Factor-{alpha}.

X. Cao, F. Kambe, and H. Seo (2005)
Endocrinology 146, 1999-2005
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Nuclear Factor-{kappa}B Decoys Suppress Endotoxin-Induced Lung Injury.

D. Baetz, J. Shaw, and L. A. Kirshenbaum (2005)
Mol. Pharmacol. 67, 977-979
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Ethyl Pyruvate Inhibits Nuclear Factor-{kappa}B-Dependent Signaling by Directly Targeting p65.

Y. Han, J. A. Englert, R. Yang, R. L. Delude, and M. P. Fink (2005)
J. Pharmacol. Exp. Ther. 312, 1097-1105
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Antiapoptotic Effect of Serum and Glucocorticoid-Inducible Protein Kinase Is Mediated by Novel Mechanism Activating I{kappa}B Kinase.

L. Zhang, R. Cui, X. Cheng, and J. Du (2005)
Cancer Res. 65, 457-464
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Nuclear Factor-{kappa}B Represses Hypoxia-Induced Mitochondrial Defects and Cell Death of Ventricular Myocytes.

K. M. Regula, D. Baetz, and L. A. Kirshenbaum (2004)
Circulation 110, 3795-3802
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T-cell Activation Leads to Poor Activation of the HIV-1 Clade E Long Terminal Repeat and Weak Association of Nuclear Factor-{kappa}B and NFAT with Its Enhancer Region.

A.-M. Lemieux, M.-E. Pare, B. Audet, E. Legault, S. Lefort, N. Boucher, S. Landry, T. van Opijnen, B. Berkhout, M. H. Naghavi, et al. (2004)
J. Biol. Chem. 279, 52949-52960
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Translational Repression Mediates Activation of Nuclear Factor Kappa B by Phosphorylated Translation Initiation Factor 2.

J. Deng, P. D. Lu, Y. Zhang, D. Scheuner, R. J. Kaufman, N. Sonenberg, H. P. Harding, and D. Ron (2004)
Mol. Cell. Biol. 24, 10161-10168
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Vascular Endothelial Growth Factor- and Thrombin-induced Termination Factor, Down Syndrome Critical Region-1, Attenuates Endothelial Cell Proliferation and Angiogenesis.

T. Minami, K. Horiuchi, M. Miura, Md. R. Abid, W. Takabe, N. Noguchi, T. Kohro, X. Ge, H. Aburatani, T. Hamakubo, et al. (2004)
J. Biol. Chem. 279, 50537-50554
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Differential Gene Expression Modulated by the Cytoplasmic Domain of Fc{gamma}RIa (CD64) {alpha}-Chain.

H. Qin, J. C. Edberg, A. W. Gibson, G. P. Page, L. Teng, and R. P. Kimberly (2004)
J. Immunol. 173, 6211-6219
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Intracellular Stress Signaling Pathways Activated During Human Islet Preparation and Following Acute Cytokine Exposure.

S. Abdelli, J. Ansite, R. Roduit, T. Borsello, I. Matsumoto, T. Sawada, N. Allaman-Pillet, H. Henry, J. S. Beckmann, B. J. Hering, et al. (2004)
Diabetes 53, 2815-2823
 |  Abstract »  |  Full Text »  |  PDF »

Corticosteroid resistance in rheumatoid arthritis: molecular and cellular perspectives.

I. C. Chikanza and D. L. Kozaci (2004)
Rheumatology 43, 1337-1345
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Overexpression of Phospholipid-hydroperoxide Glutathione Peroxidase in Human Dermal Fibroblasts Abrogates UVA Irradiation-induced Expression of Interstitial Collagenase/Matrix Metalloproteinase-1 by Suppression of Phosphatidylcholine Hydroperoxide-mediated NF{kappa}B Activation and Interleukin-6 Release.

J. Wenk, J. Schuller, C. Hinrichs, T. Syrovets, N. Azoitei, M. Podda, M. Wlaschek, P. Brenneisen, L.-A. Schneider, A. Sabiwalsky, et al. (2004)
J. Biol. Chem. 279, 45634-45642
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Expanded Nuclear Roles for I{kappa}Bs.

P. W. Bates and S. Miyamoto (2004)
Sci. STKE 2004, pe48
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NF-{kappa}B and AP-1 Connection: Mechanism of NF-{kappa}B-Dependent Regulation of AP-1 Activity.

S. Fujioka, J. Niu, C. Schmidt, G. M. Sclabas, B. Peng, T. Uwagawa, Z. Li, D. B. Evans, J. L. Abbruzzese, and P. J. Chiao (2004)
Mol. Cell. Biol. 24, 7806-7819
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{beta}-Arrestin inhibits NF-{kappa}B activity by means of its interaction with the NF-{kappa}B inhibitor I{kappa}B{alpha}.

D. S. Witherow, T. R. Garrison, W. E. Miller, and R. J. Lefkowitz (2004)
PNAS 101, 8603-8607
 |  Abstract »  |  Full Text »  |  PDF »

Intracellular Bacterial Infection-Induced IFN-{gamma} Is Critically but Not Solely Dependent on Toll-Like Receptor 4-Myeloid Differentiation Factor 88-IFN-{alpha}{beta}-STAT1 Signaling.

A. G. Rothfuchs, C. Trumstedt, H. Wigzell, and M. E. Rottenberg (2004)
J. Immunol. 172, 6345-6353
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In Vivo Chromatin Remodeling Events Leading to Inflammatory Gene Transcription under Diabetic Conditions.

F. Miao, I. G. Gonzalo, L. Lanting, and R. Natarajan (2004)
J. Biol. Chem. 279, 18091-18097
 |  Abstract »  |  Full Text »  |  PDF »

Identification of an Autoregulatory Feedback Pathway Involving Interleukin-1{alpha} in Induction of Constitutive NF-{kappa}B Activation in Pancreatic Cancer Cells.

J. Niu, Z. Li, B. Peng, and P. J. Chiao (2004)
J. Biol. Chem. 279, 16452-16462
 |  Abstract »  |  Full Text »  |  PDF »

Immunosuppressive Activity of Endovanilloids: N-Arachidonoyl-Dopamine Inhibits Activation of the NF-{kappa}B, NFAT, and Activator Protein 1 Signaling Pathways.

R. Sancho, A. Macho, L. de La Vega, M. A. Calzado, B. L. Fiebich, G. Appendino, and E. Munoz (2004)
J. Immunol. 172, 2341-2351
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Hypertonic Stress Activates Glycogen Synthase Kinase 3{beta}-mediated Apoptosis of Renal Medullary Interstitial Cells, Suppressing an NF{kappa}B-driven Cyclooxygenase-2-dependent Survival Pathway.

R. Rao, C.-M. Hao, and M. D. Breyer (2004)
J. Biol. Chem. 279, 3949-3955
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Tyrosine Kinase p56lck Regulates Cell Motility and Nuclear Factor {kappa}B-mediated Secretion of Urokinase Type Plasminogen Activator through Tyrosine Phosphorylation of I{kappa}B{alpha} following Hypoxia/Reoxygenation.

G. H. Mahabeleshwar and G. C. Kundu (2003)
J. Biol. Chem. 278, 52598-52612
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Hepatitis C Virus NS5A and Subgenomic Replicon Activate NF-{kappa}B via Tyrosine Phosphorylation of I{kappa}B{alpha} and Its Degradation by Calpain Protease.

G. Waris, A. Livolsi, V. Imbert, J.-F. Peyron, and A. Siddiqui (2003)
J. Biol. Chem. 278, 40778-40787
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NF{kappa}B Regulates Plasma Apolipoprotein A-I and High Density Lipoprotein Cholesterol through Inhibition of Peroxisome Proliferator-activated Receptor {alpha}.

A. Morishima, N. Ohkubo, N. Maeda, T. Miki, and N. Mitsuda (2003)
J. Biol. Chem. 278, 38188-38193
 |  Abstract »  |  Full Text »  |  PDF »

Hepatitis C Virus and HIV Envelope Proteins Collaboratively Mediate Interleukin-8 Secretion through Activation of p38 MAP Kinase and SHP2 in Hepatocytes.

A. Balasubramanian, R. K. Ganju, and J. E. Groopman (2003)
J. Biol. Chem. 278, 35755-35766
 |  Abstract »  |  Full Text »  |  PDF »

Recombinant TCR Ligand Induces Early TCR Signaling and a Unique Pattern of Downstream Activation.

C. Wang, J. L. Mooney, R. Meza-Romero, Y. K. Chou, J. Huan, A. A. Vandenbark, H. Offner, and G. G. Burrows (2003)
J. Immunol. 171, 1934-1940
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NF-{kappa}B Inhibits Gammaherpesvirus Lytic Replication.

H. J. Brown, M. J. Song, H. Deng, T.-T. Wu, G. Cheng, and R. Sun (2003)
J. Virol. 77, 8532-8540
 |  Abstract »  |  Full Text »  |  PDF »

Nuclear Factor-{kappa}B Mediates Angiogenesis and Metastasis of Human Bladder Cancer through the Regulation of Interleukin-8.

T. Karashima, P. Sweeney, A. Kamat, S. Huang, S. J. Kim, M. Bar-Eli, D. J. McConkey, and C. P. N. Dinney (2003)
Clin. Cancer Res. 9, 2786-2797
 |  Abstract »  |  Full Text »  |  PDF »

Yin Yang 1 Is a Lipopolysaccharide-Inducible Activator of the Murine 3' Igh Enhancer, hs3.

S. J. Gordon, S. Saleque, and B. K. Birshtein (2003)
J. Immunol. 170, 5549-5557
 |  Abstract »  |  Full Text »  |  PDF »

In Vivo Identification of Inducible Phosphoacceptors in the IKK{gamma}/NEMO Subunit of Human I{kappa}B Kinase.

R. S. Carter, K. N. Pennington, B. J. Ungurait, and D. W. Ballard (2003)
J. Biol. Chem. 278, 19642-19648
 |  Abstract »  |  Full Text »  |  PDF »

Two Distinct Phases of Virus-induced Nuclear Factor kappa B Regulation Enhance Tumor Necrosis Factor-related Apoptosis-inducing Ligand-mediated Apoptosis in Virus-infected Cells.

P. Clarke, S. M. Meintzer, L. A. Moffitt, and K. L. Tyler (2003)
J. Biol. Chem. 278, 18092-18100
 |  Abstract »  |  Full Text »  |  PDF »

Diminished Heme Oxygenase Potentiates Cell Death: Pyrrolidinedithiocarbamate Mediates Oxidative Stress.

L. Malaguarnera, S. Quan, M. R. Pilastro, N. G. Abraham, and A. Kappas (2003)
Experimental Biology and Medicine 228, 459-465
 |  Abstract »  |  Full Text »  |  PDF »

Aspirin inhibits Chlamydia pneumoniae-induced NF-{kappa}B activation, cyclo-oxygenase-2 expression and prostaglandin E2 synthesis and attenuates chlamydial growth.

H. Yoneda, K. Miura, H. Matsushima, K. Sugi, T. Murakami, K. Ouchi, K. Yamashita, H. Itoh, T. Nakazawa, M. Suzuki, et al. (2003)
J. Med. Microbiol. 52, 409-415
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of protein tyrosine kinase in Toll-like receptor 4-mediated NF-kappa B activation in human peripheral blood monocytes.

L.-Y. Chen, B. L. Zuraw, M. Zhao, F.-T. Liu, S. Huang, and Z. K. Pan (2003)
Am J Physiol Lung Cell Mol Physiol 284, L607-L613
 |  Abstract »  |  Full Text »  |  PDF »

Microtubule Disruption Utilizes an NFkappa B-dependent Pathway to Stabilize HIF-1alpha Protein.

Y.-J. Jung, J. S. Isaacs, S. Lee, J. Trepel, and L. Neckers (2003)
J. Biol. Chem. 278, 7445-7452
 |  Abstract »  |  Full Text »  |  PDF »

Down-regulation of Hydrogen Peroxide-induced PKCdelta Activation in N-Acetylglucosaminyltransferase III-transfected HeLaS3 Cells.

Y. Shibukawa, M. Takahashi, I. Laffont, K. Honke, and N. Taniguchi (2003)
J. Biol. Chem. 278, 3197-3203
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p105{middle dot}Ikappa Bgamma and Prototypical Ikappa Bs Use a Similar Mechanism to Bind but a Different Mechanism to Regulate the Subcellular Localization of NF-kappa B.

A. K. Moorthy and G. Ghosh (2003)
J. Biol. Chem. 278, 556-566
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NF-kappa B inhibition by omega -3 fatty acids modulates LPS-stimulated macrophage TNF-alpha transcription.

T. E. Novak, T. A. Babcock, D. H. Jho, W. S. Helton, and N. J. Espat (2003)
Am J Physiol Lung Cell Mol Physiol 284, L84-L89
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Nuclear Factor-{kappa}B by Corticotropin-Releasing Hormone in Mouse Thymocytes.

J. Zhao and K. P. Karalis (2002)
Mol. Endocrinol. 16, 2561-2570
 |  Abstract »  |  Full Text »  |  PDF »

IKKbeta Is Required for Bcl-2-mediated NF-kappa B Activation in Ventricular Myocytes.

K. M. Regula, K. Ens, and L. A. Kirshenbaum (2002)
J. Biol. Chem. 277, 38676-38682
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Fc{gamma}R cross-linking mediates NF-{kappa}B activation, reduced antigen presentation capacity, and decreased IL-12 production in monocytes without modulation of myeloid dendritic cell development.

Y. Drechsler, S. Chavan, D. Catalano, P. Mandrekar, and G. Szabo (2002)
J. Leukoc. Biol. 72, 657-667
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Low Intracellular Zinc Impairs the Translocation of Activated NF-kappa B to the Nuclei in Human Neuroblastoma IMR-32 Cells.

G. G. Mackenzie, M. P. Zago, C. L. Keen, and P. I. Oteiza (2002)
J. Biol. Chem. 277, 34610-34617
 |  Abstract »  |  Full Text »  |  PDF »

Heat Shock Protein 70 Is a Potential Virulence Factor in Murine Toxoplasma Infection Via Immunomodulation of Host NF-{kappa}B and Nitric Oxide.

C. A. Dobbin, N. C. Smith, and A. M. Johnson (2002)
J. Immunol. 169, 958-965
 |  Abstract »  |  Full Text »  |  PDF »

Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down-regulating nuclear factor-{kappa}B in mouse macrophages.

A.-H. Lo, Y.-C. Liang, S.-Y. Lin-Shiau, C.-T. Ho, and J.-K. Lin (2002)
Carcinogenesis 23, 983-991
 |  Abstract »  |  Full Text »  |  PDF »

Nuclear Factor Kappa B Activation and Regulation of Cyclooxygenase Type-2 Expression in Human Amnion Mesenchymal Cells by Interleukin-1{beta}.

X. Yan, C. Wu Xiao, M. Sun, B. K. Tsang, and W. Gibb (2002)
Biol Reprod 66, 1667-1671
 |  Abstract »  |  Full Text »  |  PDF »

Heme Oxygenase-1-derived Carbon Monoxide Requires the Activation of Transcription Factor NF-kappa B to Protect Endothelial Cells from Tumor Necrosis Factor-alpha -mediated Apoptosis.

S. Brouard, P. O. Berberat, E. Tobiasch, M. P. Seldon, F. H. Bach, and M. P. Soares (2002)
J. Biol. Chem. 277, 17950-17961
 |  Abstract »  |  Full Text »  |  PDF »

DNA Binding-Independent Induction of I{kappa}B{alpha} Gene Transcription by PPAR{alpha}.

P. Delerive, K. De Bosscher, W. Vanden Berghe, J.-C. Fruchart, G. Haegeman, and B. Staels (2002)
Mol. Endocrinol. 16, 1029-1039
 |  Abstract »  |  Full Text »  |  PDF »

Contrasting the Roles of Costimulation and the Natural Adjuvant Lipopolysaccharide During the Induction of T Cell Immunity.

J. R. Maxwell, C. Ruby, N. I. Kerkvliet, and A. T. Vella (2002)
J. Immunol. 168, 4372-4381
 |  Abstract »  |  Full Text »  |  PDF »

MDM2 induces NF-kappa B/p65 expression transcriptionally through Sp1-binding sites: a novel, p53-independent role of MDM2 in doxorubicin resistance in acute lymphoblastic leukemia.

L. Gu, H. W. Findley, and M. Zhou (2002)
Blood 99, 3367-3375
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Mechanisms Underlying Differential Contribution of CD28 Versus Non-CD28 Costimulatory Molecules to IL-2 Promoter Activation.

X.-Y. Zhou, Y. Yashiro-Ohtani, M. Nakahira, W. R. Park, R. Abe, T. Hamaoka, M. Naramura, H. Gu, and H. Fujiwara (2002)
J. Immunol. 168, 3847-3854
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Multi-parameter analysis of the kinetics of NF-{kappa}B signalling and transcription in single living cells.

G. Nelson, L. Paraoan, D. G. Spiller, G. J. C. Wilde, M. A. Browne, P. K. Djali, J. F. Unitt, E. Sullivan, E. Floettmann, and M. R. H. White (2002)
J. Cell Sci. 115, 1137-1148
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Effect of IgA on Respiratory Burst and Cytokine Release by Human Alveolar Macrophages . Role of ERK1/2 Mitogen-Activated Protein Kinases and NF-kappa B.

Y. Ouadrhiri, C. Pilette, R. C. Monteiro, J.-P. Vaerman, and Y. Sibille (2002)
Am. J. Respir. Cell Mol. Biol. 26, 315-332
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HIV Nef Increases T Cell ERK MAP Kinase Activity.

J. A. Schrager, V. Der Minassian, and J. W. Marsh (2002)
J. Biol. Chem. 277, 6137-6142
 |  Abstract »  |  Full Text »  |  PDF »

Cytokine Receptor Common beta Subunit-mediated STAT5 Activation Confers NF-kappa B Activation in Murine proB Cell Line Ba/F3 Cells.

T. Nakamura, R. Ouchida, T. Kodama, T. Kawashima, Y. Makino, N. Yoshikawa, S. Watanabe, C. Morimoto, T. Kitamura, and H. Tanaka (2002)
J. Biol. Chem. 277, 6254-6265
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Activation of Nuclear Factor-{kappa}B Significantly Contributes to Lumen Loss in a Rabbit Iliac Artery Balloon Angioplasty Model.

J.M. Breuss, M. Cejna, H. Bergmeister, A. Kadl, G. Baumgartl, S. Steurer, Z. Xu, Y. Koshelnick, J. Lipp, R. De Martin, et al. (2002)
Circulation 105, 633-638
 |  Abstract »  |  Full Text »  |  PDF »

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