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Science 14 October 1988:
Vol. 242. no. 4876, pp. 266 - 268
DOI: 10.1126/science.3262924
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Articles

Science, Vol 242, Issue 4876, 266-268
Copyright © 1988 by American Association for the Advancement of Science

articles

Recognition and transport of adenine derivatives with synthetic receptors

T Benzing, T Tjivikua, J Wolfe, and J Rebek Jr

Department of Chemistry, University of Pittsburgh, PA 15260.

Several new synthetic agents show high affinity for binding adenine derivatives. The structures feature complementary hydrogen bonds that cause the molecular chelation of the purine nucleus. The high lipophilicity of the new agents permits the transport of adenosine and deoxyadenosine across organic liquid membranes. The use of synthetic receptors for small biological targets may have application in drug delivery.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)